Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development
Abstract Gut microbiota regulates various aspects of human physiology by producing metabolites, metabolizing enzymes, and toxins. Many studies have linked microbiota with human health and altered microbiome configurations with the occurrence of several diseases, including cancer. Accumulating eviden...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Cellular & Molecular Biology Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11658-024-00538-0 |
| _version_ | 1797266706909888512 |
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| author | Menatallah Rayan Tahseen S. Sayed Ola J. Hussein Lubna Therachiyil Zaid H. Maayah Cristina Maccalli Shahab Uddin Jochen H. M. Prehn Hesham M. Korashy |
| author_facet | Menatallah Rayan Tahseen S. Sayed Ola J. Hussein Lubna Therachiyil Zaid H. Maayah Cristina Maccalli Shahab Uddin Jochen H. M. Prehn Hesham M. Korashy |
| author_sort | Menatallah Rayan |
| collection | DOAJ |
| description | Abstract Gut microbiota regulates various aspects of human physiology by producing metabolites, metabolizing enzymes, and toxins. Many studies have linked microbiota with human health and altered microbiome configurations with the occurrence of several diseases, including cancer. Accumulating evidence suggests that the microbiome can influence the initiation and progression of several cancers. Moreover, some microbiotas of the gut and oral cavity have been reported to infect tumors, initiate metastasis, and promote the spread of cancer to distant organs, thereby influencing the clinical outcome of cancer patients. The gut microbiome has recently been reported to interact with environmental factors such as diet and exposure to environmental toxicants. Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) induces a shift in the gut microbiome metabolic pathways, favoring a proinflammatory microenvironment. In addition, other studies have also correlated cancer incidence with exposure to PAHs. PAHs are known to induce organ carcinogenesis through activating a ligand-activated transcriptional factor termed the aryl hydrocarbon receptor (AhR), which metabolizes PAHs to highly reactive carcinogenic intermediates. However, the crosstalk between AhR and the microbiome in mediating carcinogenesis is poorly reviewed. This review aims to discuss the role of exposure to environmental pollutants and activation of AhR on microbiome-associated cancer progression and explore the underlying molecular mechanisms involved in cancer development. |
| first_indexed | 2024-04-25T01:04:58Z |
| format | Article |
| id | doaj.art-76ee664c2bb54606a2b9fc731a9a10a3 |
| institution | Directory Open Access Journal |
| issn | 1689-1392 |
| language | English |
| last_indexed | 2024-04-25T01:04:58Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cellular & Molecular Biology Letters |
| spelling | doaj.art-76ee664c2bb54606a2b9fc731a9a10a32024-03-10T12:17:55ZengBMCCellular & Molecular Biology Letters1689-13922024-03-0129112010.1186/s11658-024-00538-0Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer developmentMenatallah Rayan0Tahseen S. Sayed1Ola J. Hussein2Lubna Therachiyil3Zaid H. Maayah4Cristina Maccalli5Shahab Uddin6Jochen H. M. Prehn7Hesham M. Korashy8Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar UniversityDepartment of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar UniversityDepartment of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar UniversityDepartment of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar UniversityDepartment of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar UniversityResearch Branch, Sidra MedicineTranslational Research Institute, Academic Health System, Hamad Medical CorporationDepartment of Physiology and Medical Physics, Royal College of Surgeons in IrelandDepartment of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar UniversityAbstract Gut microbiota regulates various aspects of human physiology by producing metabolites, metabolizing enzymes, and toxins. Many studies have linked microbiota with human health and altered microbiome configurations with the occurrence of several diseases, including cancer. Accumulating evidence suggests that the microbiome can influence the initiation and progression of several cancers. Moreover, some microbiotas of the gut and oral cavity have been reported to infect tumors, initiate metastasis, and promote the spread of cancer to distant organs, thereby influencing the clinical outcome of cancer patients. The gut microbiome has recently been reported to interact with environmental factors such as diet and exposure to environmental toxicants. Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) induces a shift in the gut microbiome metabolic pathways, favoring a proinflammatory microenvironment. In addition, other studies have also correlated cancer incidence with exposure to PAHs. PAHs are known to induce organ carcinogenesis through activating a ligand-activated transcriptional factor termed the aryl hydrocarbon receptor (AhR), which metabolizes PAHs to highly reactive carcinogenic intermediates. However, the crosstalk between AhR and the microbiome in mediating carcinogenesis is poorly reviewed. This review aims to discuss the role of exposure to environmental pollutants and activation of AhR on microbiome-associated cancer progression and explore the underlying molecular mechanisms involved in cancer development.https://doi.org/10.1186/s11658-024-00538-0MicrobiomeAryl hydrocarbon receptorCancerCYP1A1Environmental pollutants |
| spellingShingle | Menatallah Rayan Tahseen S. Sayed Ola J. Hussein Lubna Therachiyil Zaid H. Maayah Cristina Maccalli Shahab Uddin Jochen H. M. Prehn Hesham M. Korashy Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development Cellular & Molecular Biology Letters Microbiome Aryl hydrocarbon receptor Cancer CYP1A1 Environmental pollutants |
| title | Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development |
| title_full | Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development |
| title_fullStr | Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development |
| title_full_unstemmed | Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development |
| title_short | Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development |
| title_sort | unlocking the secrets exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development |
| topic | Microbiome Aryl hydrocarbon receptor Cancer CYP1A1 Environmental pollutants |
| url | https://doi.org/10.1186/s11658-024-00538-0 |
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