PD-1 Regulates GABAergic Neurotransmission and GABA-Mediated Analgesia and Anesthesia

PD-1 Regulates GABAergic Neurotransmission and GABA-Mediated Analgesia and Anesthesia

Summary: The immune checkpoint inhibitor programmed cell death protein 1 (PD-1) plays a critical role in immune regulation. Recent studies have demonstrated functional PD-1 expression in peripheral sensory neurons, which contributes to neuronal excitability, pain, and opioid analgesia. Here we repor...

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Bibliographic Details
Main Authors: Changyu Jiang, Zilong Wang, Christopher R. Donnelly, Kaiyuan Wang, Amanda S. Andriessen, Xueshu Tao, Megumi Matsuda, Junli Zhao, Ru-Rong Ji
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:iScience
Subjects:
Immunology
Molecular Biology
Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220307628

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