High correlation of hepatic shear wave velocity with esophageal varices complication rate in patients with chronic liver diseases
Abstract Background Histological evaluation by liver biopsy is considered the gold standard for assessing liver disease; however, it is highly invasive. Non-invasive liver stiffness measurement by shear wave elastography (SWE) is effective for evaluating the hepatic fibrosis stage and related diseas...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-05-01
|
| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-023-02821-4 |
| _version_ | 1797817989059313664 |
|---|---|
| author | Shouichi Namikawa Takuto Nosaka Hidetaka Matsuda Yu Akazawa Kazuto Takahashi Tatsushi Naito Masahiro Ohtani Yasunari Nakamoto |
| author_facet | Shouichi Namikawa Takuto Nosaka Hidetaka Matsuda Yu Akazawa Kazuto Takahashi Tatsushi Naito Masahiro Ohtani Yasunari Nakamoto |
| author_sort | Shouichi Namikawa |
| collection | DOAJ |
| description | Abstract Background Histological evaluation by liver biopsy is considered the gold standard for assessing liver disease; however, it is highly invasive. Non-invasive liver stiffness measurement by shear wave elastography (SWE) is effective for evaluating the hepatic fibrosis stage and related diseases. In this study, we investigated the correlations of liver stiffness with hepatic inflammation/fibrosis, functional hepatic reserve, and related diseases in patients with chronic liver disease (CLD). Methods Shear wave velocity (Vs) values were measured using point SWE in 71 patients with liver disease from 2017 to 2019. Liver biopsy specimens and serum biomarkers were collected at the same time, and splenic volume was measured using computed tomography images with the software Ziostation2. Esophageal varices (EV) were evaluated by upper gastrointestinal endoscopy. Results Among CLD-related function and complications, Vs values were highly correlated with liver fibrosis and EV complication rates. The median Vs values for liver fibrosis grades F0, F1, F2, F3, and F4 were 1.18, 1.34, 1.39, 1.80, and 2.12 m/s, respectively. Comparison of receiver operating characteristic (ROC) curves to predict cirrhosis showed that area under the ROC (AUROC) curve for Vs values was 0.902, which was not significantly different from the AUROCs for the FIB-4 index, platelet count, hyaluronic acid, or type IV collagen 7S, while it was significantly different from the AUROC for mac-2 binding protein glycosylation isomer (M2BPGi) (P < 0.01). Comparison of ROC curves to predict EV showed that the AUROC for Vs values was 0.901, which was significantly higher than the AUROCs for FIB-4 index (P < 0.05), platelet count (P < 0.05), M2BPGi (P < 0.01), hyaluronic acid (P < 0.05), and splenic volume (P < 0.05). In patients with advanced liver fibrosis (F3 + F4), there was no difference in blood markers and splenic volume, while Vs value was significantly higher in patients with EV (P < 0.01). Conclusions Hepatic shear wave velocity was highly correlated with EV complication rates in chronic liver diseases as compared to blood markers and splenic volume. In advanced CLD patients, Vs values of SWE are suggested to be effective in predicting the appearance of EV noninvasively. |
| first_indexed | 2024-03-13T09:01:40Z |
| format | Article |
| id | doaj.art-76f1529df28e463caf21f3386042a6e6 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-03-13T09:01:40Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-76f1529df28e463caf21f3386042a6e62023-05-28T11:18:28ZengBMCBMC Gastroenterology1471-230X2023-05-012311910.1186/s12876-023-02821-4High correlation of hepatic shear wave velocity with esophageal varices complication rate in patients with chronic liver diseasesShouichi Namikawa0Takuto Nosaka1Hidetaka Matsuda2Yu Akazawa3Kazuto Takahashi4Tatsushi Naito5Masahiro Ohtani6Yasunari Nakamoto7Second Department of Internal Medicine, Faculty of Medical Sciences, University of FukuiSecond Department of Internal Medicine, Faculty of Medical Sciences, University of FukuiSecond Department of Internal Medicine, Faculty of Medical Sciences, University of FukuiSecond Department of Internal Medicine, Faculty of Medical Sciences, University of FukuiSecond Department of Internal Medicine, Faculty of Medical Sciences, University of FukuiSecond Department of Internal Medicine, Faculty of Medical Sciences, University of FukuiSecond Department of Internal Medicine, Faculty of Medical Sciences, University of FukuiSecond Department of Internal Medicine, Faculty of Medical Sciences, University of FukuiAbstract Background Histological evaluation by liver biopsy is considered the gold standard for assessing liver disease; however, it is highly invasive. Non-invasive liver stiffness measurement by shear wave elastography (SWE) is effective for evaluating the hepatic fibrosis stage and related diseases. In this study, we investigated the correlations of liver stiffness with hepatic inflammation/fibrosis, functional hepatic reserve, and related diseases in patients with chronic liver disease (CLD). Methods Shear wave velocity (Vs) values were measured using point SWE in 71 patients with liver disease from 2017 to 2019. Liver biopsy specimens and serum biomarkers were collected at the same time, and splenic volume was measured using computed tomography images with the software Ziostation2. Esophageal varices (EV) were evaluated by upper gastrointestinal endoscopy. Results Among CLD-related function and complications, Vs values were highly correlated with liver fibrosis and EV complication rates. The median Vs values for liver fibrosis grades F0, F1, F2, F3, and F4 were 1.18, 1.34, 1.39, 1.80, and 2.12 m/s, respectively. Comparison of receiver operating characteristic (ROC) curves to predict cirrhosis showed that area under the ROC (AUROC) curve for Vs values was 0.902, which was not significantly different from the AUROCs for the FIB-4 index, platelet count, hyaluronic acid, or type IV collagen 7S, while it was significantly different from the AUROC for mac-2 binding protein glycosylation isomer (M2BPGi) (P < 0.01). Comparison of ROC curves to predict EV showed that the AUROC for Vs values was 0.901, which was significantly higher than the AUROCs for FIB-4 index (P < 0.05), platelet count (P < 0.05), M2BPGi (P < 0.01), hyaluronic acid (P < 0.05), and splenic volume (P < 0.05). In patients with advanced liver fibrosis (F3 + F4), there was no difference in blood markers and splenic volume, while Vs value was significantly higher in patients with EV (P < 0.01). Conclusions Hepatic shear wave velocity was highly correlated with EV complication rates in chronic liver diseases as compared to blood markers and splenic volume. In advanced CLD patients, Vs values of SWE are suggested to be effective in predicting the appearance of EV noninvasively.https://doi.org/10.1186/s12876-023-02821-4Esophageal varicesShear wave velocityChronic liver disease |
| spellingShingle | Shouichi Namikawa Takuto Nosaka Hidetaka Matsuda Yu Akazawa Kazuto Takahashi Tatsushi Naito Masahiro Ohtani Yasunari Nakamoto High correlation of hepatic shear wave velocity with esophageal varices complication rate in patients with chronic liver diseases BMC Gastroenterology Esophageal varices Shear wave velocity Chronic liver disease |
| title | High correlation of hepatic shear wave velocity with esophageal varices complication rate in patients with chronic liver diseases |
| title_full | High correlation of hepatic shear wave velocity with esophageal varices complication rate in patients with chronic liver diseases |
| title_fullStr | High correlation of hepatic shear wave velocity with esophageal varices complication rate in patients with chronic liver diseases |
| title_full_unstemmed | High correlation of hepatic shear wave velocity with esophageal varices complication rate in patients with chronic liver diseases |
| title_short | High correlation of hepatic shear wave velocity with esophageal varices complication rate in patients with chronic liver diseases |
| title_sort | high correlation of hepatic shear wave velocity with esophageal varices complication rate in patients with chronic liver diseases |
| topic | Esophageal varices Shear wave velocity Chronic liver disease |
| url | https://doi.org/10.1186/s12876-023-02821-4 |
| work_keys_str_mv | AT shouichinamikawa highcorrelationofhepaticshearwavevelocitywithesophagealvaricescomplicationrateinpatientswithchronicliverdiseases AT takutonosaka highcorrelationofhepaticshearwavevelocitywithesophagealvaricescomplicationrateinpatientswithchronicliverdiseases AT hidetakamatsuda highcorrelationofhepaticshearwavevelocitywithesophagealvaricescomplicationrateinpatientswithchronicliverdiseases AT yuakazawa highcorrelationofhepaticshearwavevelocitywithesophagealvaricescomplicationrateinpatientswithchronicliverdiseases AT kazutotakahashi highcorrelationofhepaticshearwavevelocitywithesophagealvaricescomplicationrateinpatientswithchronicliverdiseases AT tatsushinaito highcorrelationofhepaticshearwavevelocitywithesophagealvaricescomplicationrateinpatientswithchronicliverdiseases AT masahiroohtani highcorrelationofhepaticshearwavevelocitywithesophagealvaricescomplicationrateinpatientswithchronicliverdiseases AT yasunarinakamoto highcorrelationofhepaticshearwavevelocitywithesophagealvaricescomplicationrateinpatientswithchronicliverdiseases |