Early onset, development and histological features of gastric signet-ring cell carcinoma
ObjectiveTo explore the early onset, development and histological features of gastric signet-ring cell carcinoma (SRCC).MethodsThree hundred and sixty-two patients with differentiated adenocarcinoma with signet-ring cells were enrolled. Histomorphological and immunohistochemical features and pattern...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1166549/full |
| _version_ | 1797785585908187136 |
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| author | Yangkun Wang Yingying Li Bin Wang Dongmei Ran Chaoya Zhu Ping Li Bo Jiang Sunan Wang |
| author_facet | Yangkun Wang Yingying Li Bin Wang Dongmei Ran Chaoya Zhu Ping Li Bo Jiang Sunan Wang |
| author_sort | Yangkun Wang |
| collection | DOAJ |
| description | ObjectiveTo explore the early onset, development and histological features of gastric signet-ring cell carcinoma (SRCC).MethodsThree hundred and sixty-two patients with differentiated adenocarcinoma with signet-ring cells were enrolled. Histomorphological and immunohistochemical features and patterns of the specimens were observed in detail.ResultsInfection of the gastric mucosa, especially by Helicobacter pylori, can cause massive cell proliferation and transformation in the deep gastric foveola, the isthmus of the gastric gland, and the proliferative zone of the upper neck of the gland. Signet-ring-like heterocysts monoclonally proliferated after the redifferentiation and reproliferation, extending horizontally along the gastric foveola. Gastric foveolar-type SRCC grew infiltratively into the lamina propria of the mucosa and the submucosa, signet-ring cells could differentiate into undifferentiated adenocarcinoma with signet-ring cell differentiation, mucinous adenocarcinoma with signet-ring cell differentiation, gastric adenocarcinoma with signet-ring cell differentiation, and fundus gland adenocarcinoma with signet-ring cell differentiation.ConclusionEarly SRCC developed from the proliferative zones of the fundus of the gastric foveola and the neck of the gastric gland, growing horizontally along the gastric foveola. It developed into gastric adenocarcinoma with signet-ring cell differentiation after reproliferation and retransformation in the mucosa. |
| first_indexed | 2024-03-13T00:57:09Z |
| format | Article |
| id | doaj.art-76f288b5aea2408c98f3de7cdf2c76ce |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T00:57:09Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-76f288b5aea2408c98f3de7cdf2c76ce2023-07-06T18:38:42ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-07-011310.3389/fonc.2023.11665491166549Early onset, development and histological features of gastric signet-ring cell carcinomaYangkun Wang0Yingying Li1Bin Wang2Dongmei Ran3Chaoya Zhu4Ping Li5Bo Jiang6Sunan Wang7Department of Pathology, Shenzhen Longgang District Fourth People’s Hospital, Shenzhen, ChinaShenzhen Polytechnic, Shenzhen, ChinaDepartment of Radiation Therapy, Cancer Center, Shanghai Jiahui International Hospital, Shanghai, ChinaDepartment of Pathology, Southern University of Science and Technology Hospital, Shenzhen, ChinaDepartment of Pathology, Third Affiliated Hospital of Zhengzhou University, Shenzhen, ChinaDepartment of Pathology, Peking University Shenzhen Hospital, Shenzhen, ChinaDepartment of Pathology, No. 990 Hospital of The People's Liberation Army (PLA) Joint Logistics Support Force, Zhumadian, ChinaShenzhen Polytechnic, Shenzhen, ChinaObjectiveTo explore the early onset, development and histological features of gastric signet-ring cell carcinoma (SRCC).MethodsThree hundred and sixty-two patients with differentiated adenocarcinoma with signet-ring cells were enrolled. Histomorphological and immunohistochemical features and patterns of the specimens were observed in detail.ResultsInfection of the gastric mucosa, especially by Helicobacter pylori, can cause massive cell proliferation and transformation in the deep gastric foveola, the isthmus of the gastric gland, and the proliferative zone of the upper neck of the gland. Signet-ring-like heterocysts monoclonally proliferated after the redifferentiation and reproliferation, extending horizontally along the gastric foveola. Gastric foveolar-type SRCC grew infiltratively into the lamina propria of the mucosa and the submucosa, signet-ring cells could differentiate into undifferentiated adenocarcinoma with signet-ring cell differentiation, mucinous adenocarcinoma with signet-ring cell differentiation, gastric adenocarcinoma with signet-ring cell differentiation, and fundus gland adenocarcinoma with signet-ring cell differentiation.ConclusionEarly SRCC developed from the proliferative zones of the fundus of the gastric foveola and the neck of the gastric gland, growing horizontally along the gastric foveola. It developed into gastric adenocarcinoma with signet-ring cell differentiation after reproliferation and retransformation in the mucosa.https://www.frontiersin.org/articles/10.3389/fonc.2023.1166549/fullgastric foveolar epithelial typehistopathologyimmunohistochemistry signet-ring cell carcinomasignet-ring cell differentiationsignet-ring-like heterocysts |
| spellingShingle | Yangkun Wang Yingying Li Bin Wang Dongmei Ran Chaoya Zhu Ping Li Bo Jiang Sunan Wang Early onset, development and histological features of gastric signet-ring cell carcinoma Frontiers in Oncology gastric foveolar epithelial type histopathology immunohistochemistry signet-ring cell carcinoma signet-ring cell differentiation signet-ring-like heterocysts |
| title | Early onset, development and histological features of gastric signet-ring cell carcinoma |
| title_full | Early onset, development and histological features of gastric signet-ring cell carcinoma |
| title_fullStr | Early onset, development and histological features of gastric signet-ring cell carcinoma |
| title_full_unstemmed | Early onset, development and histological features of gastric signet-ring cell carcinoma |
| title_short | Early onset, development and histological features of gastric signet-ring cell carcinoma |
| title_sort | early onset development and histological features of gastric signet ring cell carcinoma |
| topic | gastric foveolar epithelial type histopathology immunohistochemistry signet-ring cell carcinoma signet-ring cell differentiation signet-ring-like heterocysts |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1166549/full |
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