Hyperendemic Dengue and Possible Zika Circulation in the Westernmost Region of the Indonesian Archipelago
The transmission of dengue and other medically important mosquito-borne viruses in the westernmost region of Indonesia is not well described. We assessed dengue and Zika virus seroprevalence in Aceh province, the westernmost area of the Indonesian archipelago. Serum samples collected from 199 random...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/2/219 |
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| author | Harapan Harapan Kritu Panta Alice Michie Timo Ernst Suzi McCarthy Muhsin Muhsin Safarianti Safarianti Tjut Mariam Zanaria Mudatsir Mudatsir R. Tedjo Sasmono Allison Imrie |
| author_facet | Harapan Harapan Kritu Panta Alice Michie Timo Ernst Suzi McCarthy Muhsin Muhsin Safarianti Safarianti Tjut Mariam Zanaria Mudatsir Mudatsir R. Tedjo Sasmono Allison Imrie |
| author_sort | Harapan Harapan |
| collection | DOAJ |
| description | The transmission of dengue and other medically important mosquito-borne viruses in the westernmost region of Indonesia is not well described. We assessed dengue and Zika virus seroprevalence in Aceh province, the westernmost area of the Indonesian archipelago. Serum samples collected from 199 randomly sampled healthy residents of Aceh Jaya in 2017 were analyzed for neutralizing antibodies by plaque reduction neutralization test (PRNT). Almost all study participants (198/199; 99.5%) presented with multitypic profiles of neutralizing antibodies to two or more DENV serotypes, indicating transmission of multiple DENV in the region prior to 2017. All residents were exposed to one or more DENV serotypes by the age of 30 years. The highest geometric mean titers were measured for DENV-4, followed by DENV-1, DENV-2 and DENV-3. Among a subset of 116 sera, 27 neutralized ZIKV with a high stringency (20 with PRNT<sub>90</sub> > 10 and 7 with PRNT<sub>90</sub> > 40). This study showed that DENV is hyperendemic in the westernmost region of the Indonesian archipelago and suggested that ZIKV may have circulated prior to 2017. |
| first_indexed | 2024-03-09T20:52:37Z |
| format | Article |
| id | doaj.art-76f291fdbd1640278fa37a402723381b |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T20:52:37Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-76f291fdbd1640278fa37a402723381b2023-11-23T22:29:25ZengMDPI AGViruses1999-49152022-01-0114221910.3390/v14020219Hyperendemic Dengue and Possible Zika Circulation in the Westernmost Region of the Indonesian ArchipelagoHarapan Harapan0Kritu Panta1Alice Michie2Timo Ernst3Suzi McCarthy4Muhsin Muhsin5Safarianti Safarianti6Tjut Mariam Zanaria7Mudatsir Mudatsir8R. Tedjo Sasmono9Allison Imrie10Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, IndonesiaSchool of Biomedical Sciences, University of Western Australia, Nedlands, WA 6009, AustraliaSchool of Biomedical Sciences, University of Western Australia, Nedlands, WA 6009, AustraliaSchool of Biomedical Sciences, University of Western Australia, Nedlands, WA 6009, AustraliaSchool of Biomedical Sciences, University of Western Australia, Nedlands, WA 6009, AustraliaDepartment of Internal Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, IndonesiaDepartment of Parasitology, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, IndonesiaDepartment of Parasitology, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, IndonesiaMedical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, IndonesiaEijkman Institute for Molecular Biology, Jakarta 10430, IndonesiaSchool of Biomedical Sciences, University of Western Australia, Nedlands, WA 6009, AustraliaThe transmission of dengue and other medically important mosquito-borne viruses in the westernmost region of Indonesia is not well described. We assessed dengue and Zika virus seroprevalence in Aceh province, the westernmost area of the Indonesian archipelago. Serum samples collected from 199 randomly sampled healthy residents of Aceh Jaya in 2017 were analyzed for neutralizing antibodies by plaque reduction neutralization test (PRNT). Almost all study participants (198/199; 99.5%) presented with multitypic profiles of neutralizing antibodies to two or more DENV serotypes, indicating transmission of multiple DENV in the region prior to 2017. All residents were exposed to one or more DENV serotypes by the age of 30 years. The highest geometric mean titers were measured for DENV-4, followed by DENV-1, DENV-2 and DENV-3. Among a subset of 116 sera, 27 neutralized ZIKV with a high stringency (20 with PRNT<sub>90</sub> > 10 and 7 with PRNT<sub>90</sub> > 40). This study showed that DENV is hyperendemic in the westernmost region of the Indonesian archipelago and suggested that ZIKV may have circulated prior to 2017.https://www.mdpi.com/1999-4915/14/2/219dengueZikaseroprevalencePRNTAcehIndonesia |
| spellingShingle | Harapan Harapan Kritu Panta Alice Michie Timo Ernst Suzi McCarthy Muhsin Muhsin Safarianti Safarianti Tjut Mariam Zanaria Mudatsir Mudatsir R. Tedjo Sasmono Allison Imrie Hyperendemic Dengue and Possible Zika Circulation in the Westernmost Region of the Indonesian Archipelago Viruses dengue Zika seroprevalence PRNT Aceh Indonesia |
| title | Hyperendemic Dengue and Possible Zika Circulation in the Westernmost Region of the Indonesian Archipelago |
| title_full | Hyperendemic Dengue and Possible Zika Circulation in the Westernmost Region of the Indonesian Archipelago |
| title_fullStr | Hyperendemic Dengue and Possible Zika Circulation in the Westernmost Region of the Indonesian Archipelago |
| title_full_unstemmed | Hyperendemic Dengue and Possible Zika Circulation in the Westernmost Region of the Indonesian Archipelago |
| title_short | Hyperendemic Dengue and Possible Zika Circulation in the Westernmost Region of the Indonesian Archipelago |
| title_sort | hyperendemic dengue and possible zika circulation in the westernmost region of the indonesian archipelago |
| topic | dengue Zika seroprevalence PRNT Aceh Indonesia |
| url | https://www.mdpi.com/1999-4915/14/2/219 |
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