Polycondensed Peptide Carriers Modified with Cyclic RGD Ligand for Targeted Suicide Gene Delivery to Uterine Fibroid Cells

Polycondensed Peptide Carriers Modified with Cyclic RGD Ligand for Targeted Suicide Gene Delivery to Uterine Fibroid Cells

Suicide gene therapy was suggested as a possible strategy for the treatment of uterine fibroids (UFs), which are the most common benign tumors inwomen of reproductive age. For successful suicide gene therapy, DNAtherapeutics should be specifically delivered to UF cells. Peptide carriers are promisin...

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Bibliographic Details
Main Authors: Anna Egorova, Sofia Shtykalova, Marianna Maretina, Alexander Selutin, Natalia Shved, Dmitriy Deviatkin, Sergey Selkov, Vladislav Baranov, Anton Kiselev
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
DNA delivery
peptide-based carriers
gene therapy
thymidine kinase
uterine fibroids
integrins
Online Access:https://www.mdpi.com/1422-0067/23/3/1164

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