Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age
In this study, we investigated blood lipoprotein and lipid fraction profiles, quantified using nuclear magnetic resonance, in a cohort of 844 healthy blood donors, integrating standard univariate and multivariate analysis with predictive modeling and network analysis. We observed a strong associatio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/11/5/326 |
| _version_ | 1797533620217315328 |
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| author | Yasmijn Balder Alessia Vignoli Leonardo Tenori Claudio Luchinat Edoardo Saccenti |
| author_facet | Yasmijn Balder Alessia Vignoli Leonardo Tenori Claudio Luchinat Edoardo Saccenti |
| author_sort | Yasmijn Balder |
| collection | DOAJ |
| description | In this study, we investigated blood lipoprotein and lipid fraction profiles, quantified using nuclear magnetic resonance, in a cohort of 844 healthy blood donors, integrating standard univariate and multivariate analysis with predictive modeling and network analysis. We observed a strong association of lipoprotein and lipid main fraction profiles with sex and age. Our results suggest an age-dependent remodulation of lipase lipoprotein activity in men and a change in the mechanisms controlling the ratio between esterified and non-esterified cholesterol in both men and women. |
| first_indexed | 2024-03-10T11:17:06Z |
| format | Article |
| id | doaj.art-76f476f6d1894da5a1db9f54ef112b13 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T11:17:06Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-76f476f6d1894da5a1db9f54ef112b132023-11-21T20:18:51ZengMDPI AGMetabolites2218-19892021-05-0111532610.3390/metabo11050326Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and AgeYasmijn Balder0Alessia Vignoli1Leonardo Tenori2Claudio Luchinat3Edoardo Saccenti4Laboratory of Systems and Synthetic Biology, Wageningen University & Research, Stippeneng 4, 6708 WE Wageningen, The NetherlandsMagnetic Resonance Center (CERM) and Department of Chemistry “Ugo Schiff”, University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, ItalyMagnetic Resonance Center (CERM) and Department of Chemistry “Ugo Schiff”, University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, ItalyMagnetic Resonance Center (CERM) and Department of Chemistry “Ugo Schiff”, University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, ItalyLaboratory of Systems and Synthetic Biology, Wageningen University & Research, Stippeneng 4, 6708 WE Wageningen, The NetherlandsIn this study, we investigated blood lipoprotein and lipid fraction profiles, quantified using nuclear magnetic resonance, in a cohort of 844 healthy blood donors, integrating standard univariate and multivariate analysis with predictive modeling and network analysis. We observed a strong association of lipoprotein and lipid main fraction profiles with sex and age. Our results suggest an age-dependent remodulation of lipase lipoprotein activity in men and a change in the mechanisms controlling the ratio between esterified and non-esterified cholesterol in both men and women.https://www.mdpi.com/2218-1989/11/5/326analysis of biological networkslipid metabolismlipidomicsmetabolomicsnuclear magnetic resonance |
| spellingShingle | Yasmijn Balder Alessia Vignoli Leonardo Tenori Claudio Luchinat Edoardo Saccenti Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age Metabolites analysis of biological networks lipid metabolism lipidomics metabolomics nuclear magnetic resonance |
| title | Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age |
| title_full | Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age |
| title_fullStr | Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age |
| title_full_unstemmed | Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age |
| title_short | Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age |
| title_sort | exploration of blood lipoprotein and lipid fraction profiles in healthy subjects through integrated univariate multivariate and network analysis reveals association of lipase activity and cholesterol esterification with sex and age |
| topic | analysis of biological networks lipid metabolism lipidomics metabolomics nuclear magnetic resonance |
| url | https://www.mdpi.com/2218-1989/11/5/326 |
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