(+)-Usnic Acid and Its Derivatives as Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses

(+)-Usnic Acid and Its Derivatives as Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses

In order to test the antiviral activity, a series of usnic acid derivatives were synthesized, including new, previously undescribed compounds. The activity of the derivatives against three strains of SARS-CoV-2 virus was studied. To understand the mechanism of antiviral action, the inhibitory activi...

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Bibliographic Details
Main Authors:	Aleksandr S. Filimonov, Olga I. Yarovaya, Anna V. Zaykovskaya, Nadezda B. Rudometova, Dmitriy N. Shcherbakov, Varvara Yu. Chirkova, Dmitry S. Baev, Sophia S. Borisevich, Olga A. Luzina, Oleg V. Pyankov, Rinat A. Maksyutov, Nariman F. Salakhutdinov
Format:	Article
Language:	English
Published:	MDPI AG 2022-09-01
Series:	Viruses
Subjects:	usnic acid virus SARS-CoV-2 main viral protease 3CLPro surface glycoprotein S molecular modeling antiviral compound
Online Access:	https://www.mdpi.com/1999-4915/14/10/2154

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