Protocol of trans-Tasman feasibility randomised controlled trial of the Younger Women’s Wellness After Breast Cancer (YWWACP) lifestyle intervention
Abstract Background Younger women (defined as those < 50 years who are likely pre-menopausal at time of diagnosis) with breast cancer often experience persistent treatment-related side effects that adversely affect their physical and psychological wellbeing. The Women’s Wellness After Cancer Prog...
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | Pilot and Feasibility Studies |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40814-022-01114-z |
| _version_ | 1811315285753331712 |
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| author | K. Sharples N. K. Vear J. Porter-Steele D. J. Anderson T. H. Moeke-Maxwell B. B. Laing L. Young T. G. Bailey S. Benge Y. Huang E. Crowley R. Day R. Cartwright M. Findlay D. Porter M. Kuper I. Campbell A. L. McCarthy |
| author_facet | K. Sharples N. K. Vear J. Porter-Steele D. J. Anderson T. H. Moeke-Maxwell B. B. Laing L. Young T. G. Bailey S. Benge Y. Huang E. Crowley R. Day R. Cartwright M. Findlay D. Porter M. Kuper I. Campbell A. L. McCarthy |
| author_sort | K. Sharples |
| collection | DOAJ |
| description | Abstract Background Younger women (defined as those < 50 years who are likely pre-menopausal at time of diagnosis) with breast cancer often experience persistent treatment-related side effects that adversely affect their physical and psychological wellbeing. The Women’s Wellness After Cancer Program (WWACP) was adapted and piloted in Australia to address these outcomes in younger women. The aims of this feasibility study are to determine (1) the potential to translate the Younger WWACP (YWWACP) intervention to a broader population base in Aotearoa/New Zealand and Australia, and (2) the potential for success of a larger, international, phase ΙΙΙ, randomised controlled trial. Methods This bi-national, randomised, single-blinded controlled trial involves two main study sites in Aotearoa/New Zealand (Kōwhai study) and Australia (EMERALD study). Young women aged 18 to 50 years who completed intensive treatment (surgery, chemotherapy, and/or radiotherapy) for breast cancer in the previous 24 months are eligible. The potential to translate the YWWACP to women in these two populations will be assessed according to several feasibility outcomes. These include examining intervention accessibility, acceptability and uptake; intervention sustainability and adherence; the prevalence components of the intervention in the control group; intervention efficacy; participants’ perception of measurement burden; the effectiveness of planned recruitment strategies; and trial methods and procedures. The studies collectively aim to enrol 60 participants in the intervention group and 60 participants in the control group (total = 120 participants). Discussion Ethical approval has been received from the Southern Health and Disability Ethics Committee (Kōwhai ref: 19/STH/215), and UnitingCare Human Research Ethics Committee (EMERALD ref: 202103). This study will provide important data on the feasibility of the refined YWWACP in the trans-Tasman context. This study will account for and harmonise cross-country differences to ensure the success of a proposed international grant application for a phase ΙΙΙ randomised controlled trial of this program to improve outcomes in younger women living with breast cancer. Trial registration Australian New Zealand Clinical Trials Registry (ANZCTR): Kōwhai ACTRN12620000260921 , registered on 27 February 2020. EMERALD ACTRN12621000447853 , registered on 19 April 2021. |
| first_indexed | 2024-04-13T11:27:37Z |
| format | Article |
| id | doaj.art-76fa12cfe0ee42958d9321064002181f |
| institution | Directory Open Access Journal |
| issn | 2055-5784 |
| language | English |
| last_indexed | 2024-04-13T11:27:37Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Pilot and Feasibility Studies |
| spelling | doaj.art-76fa12cfe0ee42958d9321064002181f2022-12-22T02:48:39ZengBMCPilot and Feasibility Studies2055-57842022-08-018111010.1186/s40814-022-01114-zProtocol of trans-Tasman feasibility randomised controlled trial of the Younger Women’s Wellness After Breast Cancer (YWWACP) lifestyle interventionK. Sharples0N. K. Vear1J. Porter-Steele2D. J. Anderson3T. H. Moeke-Maxwell4B. B. Laing5L. Young6T. G. Bailey7S. Benge8Y. Huang9E. Crowley10R. Day11R. Cartwright12M. Findlay13D. Porter14M. Kuper15I. Campbell16A. L. McCarthy17Cancer Trials New ZealandUniversity of QueenslandWesley Choices Cancer Support CentreUniversity of TechnologyUniversity of AucklandUniversity of AucklandWesley Choices Cancer Support CentreUniversity of QueenslandCancer Trials New ZealandCancer Trials New ZealandCancer Trials New ZealandCancer Trials New ZealandCancer Trials New ZealandCancer Trials New ZealandDepartment of Oncology, Auckland HospitalDepartment of Oncology, Waikato HospitalDepartment of Surgery, Waikato HospitalUniversity of QueenslandAbstract Background Younger women (defined as those < 50 years who are likely pre-menopausal at time of diagnosis) with breast cancer often experience persistent treatment-related side effects that adversely affect their physical and psychological wellbeing. The Women’s Wellness After Cancer Program (WWACP) was adapted and piloted in Australia to address these outcomes in younger women. The aims of this feasibility study are to determine (1) the potential to translate the Younger WWACP (YWWACP) intervention to a broader population base in Aotearoa/New Zealand and Australia, and (2) the potential for success of a larger, international, phase ΙΙΙ, randomised controlled trial. Methods This bi-national, randomised, single-blinded controlled trial involves two main study sites in Aotearoa/New Zealand (Kōwhai study) and Australia (EMERALD study). Young women aged 18 to 50 years who completed intensive treatment (surgery, chemotherapy, and/or radiotherapy) for breast cancer in the previous 24 months are eligible. The potential to translate the YWWACP to women in these two populations will be assessed according to several feasibility outcomes. These include examining intervention accessibility, acceptability and uptake; intervention sustainability and adherence; the prevalence components of the intervention in the control group; intervention efficacy; participants’ perception of measurement burden; the effectiveness of planned recruitment strategies; and trial methods and procedures. The studies collectively aim to enrol 60 participants in the intervention group and 60 participants in the control group (total = 120 participants). Discussion Ethical approval has been received from the Southern Health and Disability Ethics Committee (Kōwhai ref: 19/STH/215), and UnitingCare Human Research Ethics Committee (EMERALD ref: 202103). This study will provide important data on the feasibility of the refined YWWACP in the trans-Tasman context. This study will account for and harmonise cross-country differences to ensure the success of a proposed international grant application for a phase ΙΙΙ randomised controlled trial of this program to improve outcomes in younger women living with breast cancer. Trial registration Australian New Zealand Clinical Trials Registry (ANZCTR): Kōwhai ACTRN12620000260921 , registered on 27 February 2020. EMERALD ACTRN12621000447853 , registered on 19 April 2021.https://doi.org/10.1186/s40814-022-01114-zBreast cancerFeasibilityAcceptabilityTranslation |
| spellingShingle | K. Sharples N. K. Vear J. Porter-Steele D. J. Anderson T. H. Moeke-Maxwell B. B. Laing L. Young T. G. Bailey S. Benge Y. Huang E. Crowley R. Day R. Cartwright M. Findlay D. Porter M. Kuper I. Campbell A. L. McCarthy Protocol of trans-Tasman feasibility randomised controlled trial of the Younger Women’s Wellness After Breast Cancer (YWWACP) lifestyle intervention Pilot and Feasibility Studies Breast cancer Feasibility Acceptability Translation |
| title | Protocol of trans-Tasman feasibility randomised controlled trial of the Younger Women’s Wellness After Breast Cancer (YWWACP) lifestyle intervention |
| title_full | Protocol of trans-Tasman feasibility randomised controlled trial of the Younger Women’s Wellness After Breast Cancer (YWWACP) lifestyle intervention |
| title_fullStr | Protocol of trans-Tasman feasibility randomised controlled trial of the Younger Women’s Wellness After Breast Cancer (YWWACP) lifestyle intervention |
| title_full_unstemmed | Protocol of trans-Tasman feasibility randomised controlled trial of the Younger Women’s Wellness After Breast Cancer (YWWACP) lifestyle intervention |
| title_short | Protocol of trans-Tasman feasibility randomised controlled trial of the Younger Women’s Wellness After Breast Cancer (YWWACP) lifestyle intervention |
| title_sort | protocol of trans tasman feasibility randomised controlled trial of the younger women s wellness after breast cancer ywwacp lifestyle intervention |
| topic | Breast cancer Feasibility Acceptability Translation |
| url | https://doi.org/10.1186/s40814-022-01114-z |
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