1-{(1<i>S</i>,2<i>S</i>,4<i>R</i>)-7,7-Dimethyl-1-[(pyrrolidin-1-yl)methyl]bicyclo [2.2.1]heptan-2-yl}-1<i>H</i>-benzo[<i>d</i>]imidazole

1-{(1<i>S</i>,2<i>S</i>,4<i>R</i>)-7,7-Dimethyl-1-[(pyrrolidin-1-yl)methyl]bicyclo [2.2.1]heptan-2-yl}-1<i>H</i>-benzo[<i>d</i>]imidazole

A three-step synthesis of 1-{(1<i>S</i>,2<i>S</i>,4<i>R</i>)-7,7-dimethyl-1-[(pyrrolidin-1-yl)methyl]bicyclo[2.2.1]heptan-2-yl}-1<i>H</i>-benzo[<i>d</i>]imidazole, prepared from camphor derived diamine, is disclosed. The absolute configurat...

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Bibliographic Details
Main Authors:	Luka Ciber, Franc Požgan, Jurij Svete, Bogdan Štefane, Uroš Grošelj
Format:	Article
Language:	English
Published:	MDPI AG 2023-01-01
Series:	Molbank
Subjects:	camphor bifunctional noncovalent organocatalysts benzo[<i>d</i>]imidazole Michael addition 2-fluoronitrobenzene nucleophilic aromatic substitution
Online Access:	https://www.mdpi.com/1422-8599/2023/1/M1538

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Summary:	A three-step synthesis of 1-{(1<i>S</i>,2<i>S</i>,4<i>R</i>)-7,7-dimethyl-1-[(pyrrolidin-1-yl)methyl]bicyclo[2.2.1]heptan-2-yl}-1<i>H</i>-benzo[<i>d</i>]imidazole, prepared from camphor derived diamine, is disclosed. The absolute configuration at the chiral center bearing benzo[<i>d</i>]imidazole moiety was confirmed by NOESY. The structure of a newly synthesized compound was confirmed by <sup>1</sup>H- and <sup>13</sup>C-NMR, 2D NMR, IR spectroscopy, and high resolution mass-spectrometry.
ISSN:	1422-8599