Long term administration of loquat leaves and their major component, ursolic acid, attenuated endogenous amyloid-β burden and memory impairment

Long term administration of loquat leaves and their major component, ursolic acid, attenuated endogenous amyloid-β burden and memory impairment

Abstract Loquat (Eriobotrya japonica) leaves contain many bioactive components such as ursolic acid (UA) and amygdalin. We investigated the effects of loquat leaf powder and methanol extract in human neuroglioma H4 cells stably expressing the Swedish-type APP695 (APPNL-H4 cells) and C57BL/6 J mice....

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Main Authors: Kensuke Iwasa, Sosuke Yagishita, Nan Yagishita-Kyo, Anzu Yamagishi, Shinji Yamamoto, Kota Yamashina, Chikara Haruta, Masashi Asai, Kei Maruyama, Kuniyoshi Shimizu, Keisuke Yoshikawa
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-44098-3

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https://doi.org/10.1038/s41598-023-44098-3

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