Augmenting endogenous Wnt signaling improves skin wound healing.
Wnt signaling is required for both the development and homeostasis of the skin, yet its contribution to skin wound repair remains controversial. By employing Axin2(LacZ/+) reporter mice we evaluated the spatial and temporal distribution patterns of Wnt responsive cells, and found that the pattern of...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3799989?pdf=render |
| _version_ | 1819069474593046528 |
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| author | Jemima L Whyte Andrew A Smith Bo Liu Wilfred R Manzano Nick D Evans Girija R Dhamdhere Mark Y Fang Howard Y Chang Anthony E Oro Jill A Helms |
| author_facet | Jemima L Whyte Andrew A Smith Bo Liu Wilfred R Manzano Nick D Evans Girija R Dhamdhere Mark Y Fang Howard Y Chang Anthony E Oro Jill A Helms |
| author_sort | Jemima L Whyte |
| collection | DOAJ |
| description | Wnt signaling is required for both the development and homeostasis of the skin, yet its contribution to skin wound repair remains controversial. By employing Axin2(LacZ/+) reporter mice we evaluated the spatial and temporal distribution patterns of Wnt responsive cells, and found that the pattern of Wnt responsiveness varies with the hair cycle, and correlates with wound healing potential. Using Axin2(LacZ/LacZ) mice and an ear wound model, we demonstrate that amplified Wnt signaling leads to improved healing. Utilizing a biochemical approach that mimics the amplified Wnt response of Axin2(LacZ/LacZ) mice, we show that topical application of liposomal Wnt3a to a non-healing wound enhances endogenous Wnt signaling, and results in better skin wound healing. Given the importance of Wnt signaling in the maintenance and repair of skin, liposomal Wnt3a may have widespread application in clinical practice. |
| first_indexed | 2024-12-21T16:50:37Z |
| format | Article |
| id | doaj.art-76fc897f160d48f3b2837cb6523adc4d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T16:50:37Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-76fc897f160d48f3b2837cb6523adc4d2022-12-21T18:56:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01810e7688310.1371/journal.pone.0076883Augmenting endogenous Wnt signaling improves skin wound healing.Jemima L WhyteAndrew A SmithBo LiuWilfred R ManzanoNick D EvansGirija R DhamdhereMark Y FangHoward Y ChangAnthony E OroJill A HelmsWnt signaling is required for both the development and homeostasis of the skin, yet its contribution to skin wound repair remains controversial. By employing Axin2(LacZ/+) reporter mice we evaluated the spatial and temporal distribution patterns of Wnt responsive cells, and found that the pattern of Wnt responsiveness varies with the hair cycle, and correlates with wound healing potential. Using Axin2(LacZ/LacZ) mice and an ear wound model, we demonstrate that amplified Wnt signaling leads to improved healing. Utilizing a biochemical approach that mimics the amplified Wnt response of Axin2(LacZ/LacZ) mice, we show that topical application of liposomal Wnt3a to a non-healing wound enhances endogenous Wnt signaling, and results in better skin wound healing. Given the importance of Wnt signaling in the maintenance and repair of skin, liposomal Wnt3a may have widespread application in clinical practice.http://europepmc.org/articles/PMC3799989?pdf=render |
| spellingShingle | Jemima L Whyte Andrew A Smith Bo Liu Wilfred R Manzano Nick D Evans Girija R Dhamdhere Mark Y Fang Howard Y Chang Anthony E Oro Jill A Helms Augmenting endogenous Wnt signaling improves skin wound healing. PLoS ONE |
| title | Augmenting endogenous Wnt signaling improves skin wound healing. |
| title_full | Augmenting endogenous Wnt signaling improves skin wound healing. |
| title_fullStr | Augmenting endogenous Wnt signaling improves skin wound healing. |
| title_full_unstemmed | Augmenting endogenous Wnt signaling improves skin wound healing. |
| title_short | Augmenting endogenous Wnt signaling improves skin wound healing. |
| title_sort | augmenting endogenous wnt signaling improves skin wound healing |
| url | http://europepmc.org/articles/PMC3799989?pdf=render |
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