Insights into the angiogenic effects of nanomaterials: mechanisms involved and potential applications
Abstract The vascular system, which transports oxygen and nutrients, plays an important role in wound healing, cardiovascular disease treatment and bone tissue engineering. Angiogenesis is a complex and delicate regulatory process. Vascular cells, the extracellular matrix (ECM) and angiogenic factor...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-019-0570-3 |
| _version_ | 1798026107542306816 |
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| author | Wenjing Liu Guilan Zhang Junrong Wu Yanli Zhang Jia Liu Haiyun Luo Longquan Shao |
| author_facet | Wenjing Liu Guilan Zhang Junrong Wu Yanli Zhang Jia Liu Haiyun Luo Longquan Shao |
| author_sort | Wenjing Liu |
| collection | DOAJ |
| description | Abstract The vascular system, which transports oxygen and nutrients, plays an important role in wound healing, cardiovascular disease treatment and bone tissue engineering. Angiogenesis is a complex and delicate regulatory process. Vascular cells, the extracellular matrix (ECM) and angiogenic factors are indispensable in the promotion of lumen formation and vascular maturation to support blood flow. However, the addition of growth factors or proteins involved in proangiogenic effects is not effective for regulating angiogenesis in different microenvironments. The construction of biomaterial scaffolds to achieve optimal growth conditions and earlier vascularization is undoubtedly one of the most important considerations and major challenges among engineering strategies. Nanomaterials have attracted much attention in biomedical applications due to their structure and unique photoelectric and catalytic properties. Nanomaterials not only serve as carriers that effectively deliver factors such as angiogenesis-related proteins and mRNA but also simulate the nano-topological structure of the primary ECM of blood vessels and stimulate the gene expression of angiogenic effects facilitating angiogenesis. Therefore, the introduction of nanomaterials to promote angiogenesis is a great helpful to the success of tissue regeneration and some ischaemic diseases. This review focuses on the angiogenic effects of nanoscaffolds in different types of tissue regeneration and discusses the influencing factors as well as possible related mechanisms of nanomaterials in endothelial neovascularization. It contributes novel insights into the design and development of novel nanomaterials for vascularization and therapeutic applications. |
| first_indexed | 2024-04-11T18:31:00Z |
| format | Article |
| id | doaj.art-76ffe79744994b1684dcf5a28c4889f9 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T18:31:00Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-76ffe79744994b1684dcf5a28c4889f92022-12-22T04:09:28ZengBMCJournal of Nanobiotechnology1477-31552020-01-0118112210.1186/s12951-019-0570-3Insights into the angiogenic effects of nanomaterials: mechanisms involved and potential applicationsWenjing Liu0Guilan Zhang1Junrong Wu2Yanli Zhang3Jia Liu4Haiyun Luo5Longquan Shao6Stomatological Hospital, Southern Medical UniversityStomatological Hospital, Southern Medical UniversityStomatological Hospital, Southern Medical UniversityStomatological Hospital, Southern Medical UniversityStomatological Hospital, Southern Medical UniversityStomatological Hospital, Southern Medical UniversityStomatological Hospital, Southern Medical UniversityAbstract The vascular system, which transports oxygen and nutrients, plays an important role in wound healing, cardiovascular disease treatment and bone tissue engineering. Angiogenesis is a complex and delicate regulatory process. Vascular cells, the extracellular matrix (ECM) and angiogenic factors are indispensable in the promotion of lumen formation and vascular maturation to support blood flow. However, the addition of growth factors or proteins involved in proangiogenic effects is not effective for regulating angiogenesis in different microenvironments. The construction of biomaterial scaffolds to achieve optimal growth conditions and earlier vascularization is undoubtedly one of the most important considerations and major challenges among engineering strategies. Nanomaterials have attracted much attention in biomedical applications due to their structure and unique photoelectric and catalytic properties. Nanomaterials not only serve as carriers that effectively deliver factors such as angiogenesis-related proteins and mRNA but also simulate the nano-topological structure of the primary ECM of blood vessels and stimulate the gene expression of angiogenic effects facilitating angiogenesis. Therefore, the introduction of nanomaterials to promote angiogenesis is a great helpful to the success of tissue regeneration and some ischaemic diseases. This review focuses on the angiogenic effects of nanoscaffolds in different types of tissue regeneration and discusses the influencing factors as well as possible related mechanisms of nanomaterials in endothelial neovascularization. It contributes novel insights into the design and development of novel nanomaterials for vascularization and therapeutic applications.https://doi.org/10.1186/s12951-019-0570-3NanomaterialsBlood vesselEndothelial cellsAngiogenesisTissue regenerationAngiogenic property |
| spellingShingle | Wenjing Liu Guilan Zhang Junrong Wu Yanli Zhang Jia Liu Haiyun Luo Longquan Shao Insights into the angiogenic effects of nanomaterials: mechanisms involved and potential applications Journal of Nanobiotechnology Nanomaterials Blood vessel Endothelial cells Angiogenesis Tissue regeneration Angiogenic property |
| title | Insights into the angiogenic effects of nanomaterials: mechanisms involved and potential applications |
| title_full | Insights into the angiogenic effects of nanomaterials: mechanisms involved and potential applications |
| title_fullStr | Insights into the angiogenic effects of nanomaterials: mechanisms involved and potential applications |
| title_full_unstemmed | Insights into the angiogenic effects of nanomaterials: mechanisms involved and potential applications |
| title_short | Insights into the angiogenic effects of nanomaterials: mechanisms involved and potential applications |
| title_sort | insights into the angiogenic effects of nanomaterials mechanisms involved and potential applications |
| topic | Nanomaterials Blood vessel Endothelial cells Angiogenesis Tissue regeneration Angiogenic property |
| url | https://doi.org/10.1186/s12951-019-0570-3 |
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