Long term changes in thrombocytopenia and leucopenia after HCV eradication with direct-acting antivirals
Abstract Background Thrombocytopenia due to hypersplenism is a major complication of hepatitis C virus (HCV)-associated cirrhosis. HCV eradication improves these complications in some patients, but the long-term effects of HCV eradication on these complications remain unclear, especially in patients...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-023-02829-w |
| _version_ | 1797817989282660352 |
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| author | Kazuto Tajiri Kazuhiko Okada Hiroyuki Ito Kengo Kawai Yoshiro Kashii Yoshiharu Tokimitsu Nozomu Muraishi Aiko Murayama Yuka Hayashi Masami Minemura Terumi Takahara Yukihiro Shimizu Ichiro Yasuda |
| author_facet | Kazuto Tajiri Kazuhiko Okada Hiroyuki Ito Kengo Kawai Yoshiro Kashii Yoshiharu Tokimitsu Nozomu Muraishi Aiko Murayama Yuka Hayashi Masami Minemura Terumi Takahara Yukihiro Shimizu Ichiro Yasuda |
| author_sort | Kazuto Tajiri |
| collection | DOAJ |
| description | Abstract Background Thrombocytopenia due to hypersplenism is a major complication of hepatitis C virus (HCV)-associated cirrhosis. HCV eradication improves these complications in some patients, but the long-term effects of HCV eradication on these complications remain unclear, especially in patients treated with direct acting antivirals (DAAs). The aim was to evaluate long term changes in thrombocytopenia and leucopenia after HCV eradication with DAAs. Methods The present multicenter study retrospectively evaluated changes over 5 years in thrombocytopenia and leukocytopenia, as well as changes in liver fibrosis markers and spleen size, in 115 patients with HCV-cirrhosis treated with DAAs. Results Thrombocytopenia and leukocytopenia were improved 4 weeks after DAA administration, with thrombocytopenia show further gradual improvement over the next year. Fib-4 index was markedly reduced 1 year after DAA, followed by subsequent gradual reduction over the next 4 years. Spleen size showed gradual annual reductions, with patients experiencing spleen size reduction characterized at baseline by bilirubinemia. Conclusions Rapid DAA-associated HCV eradication might lead to rapid disappearance of liver inflammation and bone marrow suppression due to HCV infection. HCV eradication may gradually improve portal hypertension, reducing spleen size. |
| first_indexed | 2024-03-13T09:01:40Z |
| format | Article |
| id | doaj.art-76fffff7635b49a088473674817e93ab |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-03-13T09:01:40Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-76fffff7635b49a088473674817e93ab2023-05-28T11:18:30ZengBMCBMC Gastroenterology1471-230X2023-05-012311810.1186/s12876-023-02829-wLong term changes in thrombocytopenia and leucopenia after HCV eradication with direct-acting antiviralsKazuto Tajiri0Kazuhiko Okada1Hiroyuki Ito2Kengo Kawai3Yoshiro Kashii4Yoshiharu Tokimitsu5Nozomu Muraishi6Aiko Murayama7Yuka Hayashi8Masami Minemura9Terumi Takahara10Yukihiro Shimizu11Ichiro Yasuda12Third Department of Internal Medicine, Faculty of Medicine, University of ToyamaGastroenterology, Toyama Red Cross HospitalGastroenterology, Takaoka Municipal HospitalGastroenterology, Nanto Municipal HospitalGastroenterology, Saiseikai Toyama HospitalGastroenterology, Toyama Red Cross HospitalThird Department of Internal Medicine, Faculty of Medicine, University of ToyamaThird Department of Internal Medicine, Faculty of Medicine, University of ToyamaThird Department of Internal Medicine, Faculty of Medicine, University of ToyamaThird Department of Internal Medicine, Faculty of Medicine, University of ToyamaThird Department of Internal Medicine, Faculty of Medicine, University of ToyamaGastroenterology, Nanto Municipal HospitalThird Department of Internal Medicine, Faculty of Medicine, University of ToyamaAbstract Background Thrombocytopenia due to hypersplenism is a major complication of hepatitis C virus (HCV)-associated cirrhosis. HCV eradication improves these complications in some patients, but the long-term effects of HCV eradication on these complications remain unclear, especially in patients treated with direct acting antivirals (DAAs). The aim was to evaluate long term changes in thrombocytopenia and leucopenia after HCV eradication with DAAs. Methods The present multicenter study retrospectively evaluated changes over 5 years in thrombocytopenia and leukocytopenia, as well as changes in liver fibrosis markers and spleen size, in 115 patients with HCV-cirrhosis treated with DAAs. Results Thrombocytopenia and leukocytopenia were improved 4 weeks after DAA administration, with thrombocytopenia show further gradual improvement over the next year. Fib-4 index was markedly reduced 1 year after DAA, followed by subsequent gradual reduction over the next 4 years. Spleen size showed gradual annual reductions, with patients experiencing spleen size reduction characterized at baseline by bilirubinemia. Conclusions Rapid DAA-associated HCV eradication might lead to rapid disappearance of liver inflammation and bone marrow suppression due to HCV infection. HCV eradication may gradually improve portal hypertension, reducing spleen size.https://doi.org/10.1186/s12876-023-02829-wHepatitis C virusThrombocytopeniaHypersplenismDirect-acting antiviral |
| spellingShingle | Kazuto Tajiri Kazuhiko Okada Hiroyuki Ito Kengo Kawai Yoshiro Kashii Yoshiharu Tokimitsu Nozomu Muraishi Aiko Murayama Yuka Hayashi Masami Minemura Terumi Takahara Yukihiro Shimizu Ichiro Yasuda Long term changes in thrombocytopenia and leucopenia after HCV eradication with direct-acting antivirals BMC Gastroenterology Hepatitis C virus Thrombocytopenia Hypersplenism Direct-acting antiviral |
| title | Long term changes in thrombocytopenia and leucopenia after HCV eradication with direct-acting antivirals |
| title_full | Long term changes in thrombocytopenia and leucopenia after HCV eradication with direct-acting antivirals |
| title_fullStr | Long term changes in thrombocytopenia and leucopenia after HCV eradication with direct-acting antivirals |
| title_full_unstemmed | Long term changes in thrombocytopenia and leucopenia after HCV eradication with direct-acting antivirals |
| title_short | Long term changes in thrombocytopenia and leucopenia after HCV eradication with direct-acting antivirals |
| title_sort | long term changes in thrombocytopenia and leucopenia after hcv eradication with direct acting antivirals |
| topic | Hepatitis C virus Thrombocytopenia Hypersplenism Direct-acting antiviral |
| url | https://doi.org/10.1186/s12876-023-02829-w |
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