Evaluation of Malondialdehyde Level, Total Oxidant/Antioxidant Status and Oxidative Stress Index in Colorectal Cancer Patients
Oxidative stress may play an important role in colorectal cancer (CRC). The present study included 94 adult patients with CRC (52 men and 42 women) and 26 hospitalized patients (12 men and 14 women) in whom CRC was excluded (control group). During hospitalization, blood serum samples were collected...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/12/11/1118 |
| _version_ | 1797464565740470272 |
|---|---|
| author | Karolina Janion Joanna Katarzyna Strzelczyk Katarzyna Weronika Walkiewicz Krzysztof Biernacki Angelika Copija Elżbieta Szczepańska Ewa Nowakowska-Zajdel |
| author_facet | Karolina Janion Joanna Katarzyna Strzelczyk Katarzyna Weronika Walkiewicz Krzysztof Biernacki Angelika Copija Elżbieta Szczepańska Ewa Nowakowska-Zajdel |
| author_sort | Karolina Janion |
| collection | DOAJ |
| description | Oxidative stress may play an important role in colorectal cancer (CRC). The present study included 94 adult patients with CRC (52 men and 42 women) and 26 hospitalized patients (12 men and 14 women) in whom CRC was excluded (control group). During hospitalization, blood serum samples were collected from both groups. Apart from that, anthropometric measurements were taken and other clinical data were analyzed. Serum malondialdehyde (MDA) level, total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) were assayed. Subsequently, the relationship between the analyzed oxidative stress markers and selected clinical characteristics was investigated in both groups. The evaluation of oxidative stress marker values demonstrated that MDA and TAS levels were significantly higher in the control group than the CRC group (<i>p</i> < 0.001 and <i>p</i> = 0.019, respectively), while TOS levels were significantly higher in the CRC group than the control group (<i>p</i> = 0.005). Significantly lower OSI levels were found in the control group than in the CRC group (<i>p</i> < 0.001). Similar results can be observed when performing ROC analysis (receiver operating characteristic curve). Preliminary statistical analysis demonstrated that MDA levels in the study group depend on the location of the primary tumour (<i>p</i> = 0.035). Based on the post hoc Tukey test, a relationship was demonstrated between the MDA level and the left and right side of the colon (<i>p</i> = 0.040). The results may be evidence for a higher level of oxidative stress, including a compromised antioxidative defence system, in patients with CRC. |
| first_indexed | 2024-03-09T18:08:57Z |
| format | Article |
| id | doaj.art-770225c787b746e184dd1828ff0a867f |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T18:08:57Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-770225c787b746e184dd1828ff0a867f2023-11-24T09:13:19ZengMDPI AGMetabolites2218-19892022-11-011211111810.3390/metabo12111118Evaluation of Malondialdehyde Level, Total Oxidant/Antioxidant Status and Oxidative Stress Index in Colorectal Cancer PatientsKarolina Janion0Joanna Katarzyna Strzelczyk1Katarzyna Weronika Walkiewicz2Krzysztof Biernacki3Angelika Copija4Elżbieta Szczepańska5Ewa Nowakowska-Zajdel6Department of Nutrition-Related Disease Prevention, Department of Metabolic Disease Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia in Katowice, 41-902 Bytom, PolandDepartment of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-808 Zabrze, PolandDepartment of Clinical Oncology, No. 4 Provincial Specialist Hospital in Bytom, 41-902 Bytom, PolandDepartment of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-808 Zabrze, PolandDepartment of Nutrition-Related Disease Prevention, Department of Metabolic Disease Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia in Katowice, 41-902 Bytom, PolandDepartment of Human Nutrition, Faculty of Health Sciences in Bytom, Medical University of Silesia in Katowice, 41-808 Zabrze, PolandDepartment of Nutrition-Related Disease Prevention, Department of Metabolic Disease Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia in Katowice, 41-902 Bytom, PolandOxidative stress may play an important role in colorectal cancer (CRC). The present study included 94 adult patients with CRC (52 men and 42 women) and 26 hospitalized patients (12 men and 14 women) in whom CRC was excluded (control group). During hospitalization, blood serum samples were collected from both groups. Apart from that, anthropometric measurements were taken and other clinical data were analyzed. Serum malondialdehyde (MDA) level, total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) were assayed. Subsequently, the relationship between the analyzed oxidative stress markers and selected clinical characteristics was investigated in both groups. The evaluation of oxidative stress marker values demonstrated that MDA and TAS levels were significantly higher in the control group than the CRC group (<i>p</i> < 0.001 and <i>p</i> = 0.019, respectively), while TOS levels were significantly higher in the CRC group than the control group (<i>p</i> = 0.005). Significantly lower OSI levels were found in the control group than in the CRC group (<i>p</i> < 0.001). Similar results can be observed when performing ROC analysis (receiver operating characteristic curve). Preliminary statistical analysis demonstrated that MDA levels in the study group depend on the location of the primary tumour (<i>p</i> = 0.035). Based on the post hoc Tukey test, a relationship was demonstrated between the MDA level and the left and right side of the colon (<i>p</i> = 0.040). The results may be evidence for a higher level of oxidative stress, including a compromised antioxidative defence system, in patients with CRC.https://www.mdpi.com/2218-1989/12/11/1118oxidative stress indexredox balancelipid peroxidationcolorectal cancer |
| spellingShingle | Karolina Janion Joanna Katarzyna Strzelczyk Katarzyna Weronika Walkiewicz Krzysztof Biernacki Angelika Copija Elżbieta Szczepańska Ewa Nowakowska-Zajdel Evaluation of Malondialdehyde Level, Total Oxidant/Antioxidant Status and Oxidative Stress Index in Colorectal Cancer Patients Metabolites oxidative stress index redox balance lipid peroxidation colorectal cancer |
| title | Evaluation of Malondialdehyde Level, Total Oxidant/Antioxidant Status and Oxidative Stress Index in Colorectal Cancer Patients |
| title_full | Evaluation of Malondialdehyde Level, Total Oxidant/Antioxidant Status and Oxidative Stress Index in Colorectal Cancer Patients |
| title_fullStr | Evaluation of Malondialdehyde Level, Total Oxidant/Antioxidant Status and Oxidative Stress Index in Colorectal Cancer Patients |
| title_full_unstemmed | Evaluation of Malondialdehyde Level, Total Oxidant/Antioxidant Status and Oxidative Stress Index in Colorectal Cancer Patients |
| title_short | Evaluation of Malondialdehyde Level, Total Oxidant/Antioxidant Status and Oxidative Stress Index in Colorectal Cancer Patients |
| title_sort | evaluation of malondialdehyde level total oxidant antioxidant status and oxidative stress index in colorectal cancer patients |
| topic | oxidative stress index redox balance lipid peroxidation colorectal cancer |
| url | https://www.mdpi.com/2218-1989/12/11/1118 |
| work_keys_str_mv | AT karolinajanion evaluationofmalondialdehydeleveltotaloxidantantioxidantstatusandoxidativestressindexincolorectalcancerpatients AT joannakatarzynastrzelczyk evaluationofmalondialdehydeleveltotaloxidantantioxidantstatusandoxidativestressindexincolorectalcancerpatients AT katarzynaweronikawalkiewicz evaluationofmalondialdehydeleveltotaloxidantantioxidantstatusandoxidativestressindexincolorectalcancerpatients AT krzysztofbiernacki evaluationofmalondialdehydeleveltotaloxidantantioxidantstatusandoxidativestressindexincolorectalcancerpatients AT angelikacopija evaluationofmalondialdehydeleveltotaloxidantantioxidantstatusandoxidativestressindexincolorectalcancerpatients AT elzbietaszczepanska evaluationofmalondialdehydeleveltotaloxidantantioxidantstatusandoxidativestressindexincolorectalcancerpatients AT ewanowakowskazajdel evaluationofmalondialdehydeleveltotaloxidantantioxidantstatusandoxidativestressindexincolorectalcancerpatients |