Agonism and antagonism at the insulin receptor.

Agonism and antagonism at the insulin receptor.

Insulin can trigger metabolic as well as mitogenic effects, the latter being pharmaceutically undesirable. An understanding of the structure/function relationships between insulin receptor (IR) binding and mitogenic/metabolic signalling would greatly facilitate the preclinical development of new ins...

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Bibliographic Details
Main Authors: Louise Knudsen, Bo Falck Hansen, Pia Jensen, Thomas Åskov Pedersen, Kirsten Vestergaard, Lauge Schäffer, Blagoy Blagoev, Martin B Oleksiewicz, Vladislav V Kiselyov, Pierre De Meyts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3531387?pdf=render

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