Autophagy dysfunction contributes to NLRP1 inflammasome-linked depressive-like behaviors in mice

Autophagy dysfunction contributes to NLRP1 inflammasome-linked depressive-like behaviors in mice

Abstract Background Major depressive disorder (MDD) is a common but severe psychiatric illness characterized by depressive mood and diminished interest. Both nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 1 (NLRP1) inflammasome and autophagy have been repo...

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Main Authors: Ya-Jing Zhu, Jing Huang, Ru Chen, Yu Zhang, Xin He, Wen-Xin Duan, Yuan-Lei Zou, Meng-Mei Sun, Hui-Li Sun, Si-Min Cheng, Hao-Chuan Wang, Hao Zhang, Wen-Ning Wu
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Neuroinflammation
Subjects:
MDD
NLRP1 inflammasome
Autophagy
CSDS
mTOR
PI3K/AKT
Online Access:https://doi.org/10.1186/s12974-023-02995-4

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