Novel Three-Finger Neurotoxins from <i>Naja melanoleuca</i> Cobra Venom Interact with GABA<sub>A</sub> and Nicotinic Acetylcholine Receptors

Novel Three-Finger Neurotoxins from <i>Naja melanoleuca</i> Cobra Venom Interact with GABA<sub>A</sub> and Nicotinic Acetylcholine Receptors

Cobra venoms contain three-finger toxins (TFT) including α-neurotoxins efficiently binding nicotinic acetylcholine receptors (nAChRs). As shown recently, several TFTs block GABA<sub>A</sub> receptors (GABA<sub>A</sub>Rs) with different efficacy, an important role of the TFTs...

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Bibliographic Details
Main Authors: Lina Son, Elena Kryukova, Rustam Ziganshin, Tatyana Andreeva, Denis Kudryavtsev, Igor Kasheverov, Victor Tsetlin, Yuri Utkin
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Toxins
Subjects:
binding sites
cobra venom
GABA<sub>A</sub> receptor
neurotoxin
three-finger toxin
nicotinic acetylcholine receptor
Online Access:https://www.mdpi.com/2072-6651/13/2/164

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