Effects of on bacterial translocation in thioacetamide-induced liver injury in rats
Background and study aim: The aim of the present study was to investigate the effects of Lycium barbarum (LB) on bacterial translocation (BT) frequency in thioacetamide (TAA)-induced liver injury in rats. Materials and methods: Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2015-12-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X15618413 |
| _version_ | 1818020096302383104 |
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| author | Y Bilgic MMM Harputluoglu O Kutlu U Demirel M Gul B Otlu I Temel S Gursoy R Dertli EB Selcuk I Yilmaz T Kilis |
| author_facet | Y Bilgic MMM Harputluoglu O Kutlu U Demirel M Gul B Otlu I Temel S Gursoy R Dertli EB Selcuk I Yilmaz T Kilis |
| author_sort | Y Bilgic |
| collection | DOAJ |
| description | Background and study aim: The aim of the present study was to investigate the effects of Lycium barbarum (LB) on bacterial translocation (BT) frequency in thioacetamide (TAA)-induced liver injury in rats. Materials and methods: Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA+LB), Lycium barbarum was administered orally 25 mg/kg for 21 days prior to the first TAA injection. In group 4 (LB), rats received only Lycium barbarum . Results: In our study, Lycium barbarum treatment did not attenuate liver damage. Lycium barbarum treatment decreased ileal E. coli counts and intestinal damage but it did not alter BT frequency. Conclusions: In conclusion, the effects of Lycium barbarum on BT may be related to ongoing severe liver damage in this model. |
| first_indexed | 2024-04-14T08:00:18Z |
| format | Article |
| id | doaj.art-7703d250717d43e5b520a3ff7c8d3ac8 |
| institution | Directory Open Access Journal |
| issn | 1721-727X |
| language | English |
| last_indexed | 2024-04-14T08:00:18Z |
| publishDate | 2015-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-7703d250717d43e5b520a3ff7c8d3ac82022-12-22T02:04:54ZengSAGE PublishingEuropean Journal of Inflammation1721-727X2015-12-011310.1177/1721727X15618413Effects of on bacterial translocation in thioacetamide-induced liver injury in ratsY Bilgic0MMM Harputluoglu1O Kutlu2U Demirel3M Gul4B Otlu5I Temel6S Gursoy7R Dertli8EB Selcuk9I Yilmaz10T Kilis11Department of Gastroenterology, Inonu University Medical Faculty, Malatya, TurkeyDepartment of Gastroenterology, Inonu University Medical Faculty, Malatya, TurkeyDepartment of Internal Medicine, Inonu University Medical Faculty, Malatya, TurkeyDepartment of Gastroenterology, Firat University Medical Faculty, Elazig, TurkeyDepartment of Histology and Embryology, Inonu University Medical Faculty, Malatya, TurkeyDepartment of Microbiology, Inonu University Medical Faculty, Malatya, TurkeyDepartment of Biochemistry, Inonu University Medical Faculty, Malatya, TurkeyDepartment of Biochemistry, Inonu University Medical Faculty, Malatya, TurkeyDepartment of Internal Medicine, Inonu University Medical Faculty, Malatya, TurkeyDepartment of Family Medicine, Inonu University Medical Faculty, Malatya, TurkeyDepartment of Pharmacology, Inonu University Pharmacy Faculty, Malatya, TurkeyDepartment of Biochemistry, Inonu University Pharmacy Faculty, Malatya, TurkeyBackground and study aim: The aim of the present study was to investigate the effects of Lycium barbarum (LB) on bacterial translocation (BT) frequency in thioacetamide (TAA)-induced liver injury in rats. Materials and methods: Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA+LB), Lycium barbarum was administered orally 25 mg/kg for 21 days prior to the first TAA injection. In group 4 (LB), rats received only Lycium barbarum . Results: In our study, Lycium barbarum treatment did not attenuate liver damage. Lycium barbarum treatment decreased ileal E. coli counts and intestinal damage but it did not alter BT frequency. Conclusions: In conclusion, the effects of Lycium barbarum on BT may be related to ongoing severe liver damage in this model.https://doi.org/10.1177/1721727X15618413 |
| spellingShingle | Y Bilgic MMM Harputluoglu O Kutlu U Demirel M Gul B Otlu I Temel S Gursoy R Dertli EB Selcuk I Yilmaz T Kilis Effects of on bacterial translocation in thioacetamide-induced liver injury in rats European Journal of Inflammation |
| title | Effects of on bacterial translocation in thioacetamide-induced liver injury in rats |
| title_full | Effects of on bacterial translocation in thioacetamide-induced liver injury in rats |
| title_fullStr | Effects of on bacterial translocation in thioacetamide-induced liver injury in rats |
| title_full_unstemmed | Effects of on bacterial translocation in thioacetamide-induced liver injury in rats |
| title_short | Effects of on bacterial translocation in thioacetamide-induced liver injury in rats |
| title_sort | effects of on bacterial translocation in thioacetamide induced liver injury in rats |
| url | https://doi.org/10.1177/1721727X15618413 |
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