The neutrophil percentage-to-albumin ratio is an independent risk factor for poor prognosis in peritoneal dialysis patients
AbstractAim This study aimed to investigate the predictive ability of the neutrophil percentage-to-albumin Ratio (NPAR) concerning all-cause mortality and cardio-cerebrovascular mortality in patients undergoing peritoneal dialysis (PD).Methods We included a total of 807 PD patients from the Peritone...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2294149 |
| _version_ | 1797316667072577536 |
|---|---|
| author | Mingfan Xu Jingjia Huan Lujie Zhu Jiachun Xu Kai Song |
| author_facet | Mingfan Xu Jingjia Huan Lujie Zhu Jiachun Xu Kai Song |
| author_sort | Mingfan Xu |
| collection | DOAJ |
| description | AbstractAim This study aimed to investigate the predictive ability of the neutrophil percentage-to-albumin Ratio (NPAR) concerning all-cause mortality and cardio-cerebrovascular mortality in patients undergoing peritoneal dialysis (PD).Methods We included a total of 807 PD patients from the Peritoneal Dialysis Center of the Second Affiliated Hospital of Soochow University between January 2009 and December 2019 in this study. Patients were categorized into three groups based on their baseline NPAR. The Kaplan-Meier method, multivariate Cox proportional hazard model, and Fine-Gray competing risk model were employed to examine the relationship between NPAR level and all-cause mortality and cardio-cerebrovascular mortality among PD patients. Furthermore, the ROC curve and calibration plots were utilized to compare the performance between NPAR and other conventional indicators.Results The mean follow-up period was 38.2 months. A total of 243 (30.1%) patients passed away, with 128 (52.7%) succumbing to cardio-cerebrovascular diseases. The mortality rates of the Middle and High NPAR groups were significantly greater than that of the Low NPAR group (p < 0.001), and NPAR was independently associated with all-cause mortality and cardio-cerebrovascular mortality. Receiver Operating Characteristic (ROC) analysis indicated that the Area Under the Curve (AUC) of NPAR (0.714) was significantly superior to those of C-reactive protein (CRP) (0.597), neutrophil to lymphocyte ratio (NLR) (0.589), C-reactive protein to albumin ratio (CAR) (0.698) and platelet to lymphocyte ratio (PLR) (0.533).Conclusion NPAR served as an independent predictive marker for all-cause mortality and cardio-cerebrovascular mortality in PD patients. Moreover, NPAR demonstrated superior predictive potential compared to CRP, CAR, NLR, and PLR. |
| first_indexed | 2024-03-08T03:22:37Z |
| format | Article |
| id | doaj.art-770403c2513f4f10b5994ab113d09b3f |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-03-08T03:22:37Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-770403c2513f4f10b5994ab113d09b3f2024-02-12T08:22:19ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2023.2294149The neutrophil percentage-to-albumin ratio is an independent risk factor for poor prognosis in peritoneal dialysis patientsMingfan Xu0Jingjia Huan1Lujie Zhu2Jiachun Xu3Kai Song4Department of Nephrology, The Second Affiliated Hospital of Soochow University China, ChinaDepartment of Nephrology, The Second Affiliated Hospital of Soochow University China, ChinaDepartment of Nephrology, The Second Affiliated Hospital of Soochow University China, ChinaDepartment of Nephrology, The Second Affiliated Hospital of Soochow University China, ChinaDepartment of Nephrology, The Second Affiliated Hospital of Soochow University China, ChinaAbstractAim This study aimed to investigate the predictive ability of the neutrophil percentage-to-albumin Ratio (NPAR) concerning all-cause mortality and cardio-cerebrovascular mortality in patients undergoing peritoneal dialysis (PD).Methods We included a total of 807 PD patients from the Peritoneal Dialysis Center of the Second Affiliated Hospital of Soochow University between January 2009 and December 2019 in this study. Patients were categorized into three groups based on their baseline NPAR. The Kaplan-Meier method, multivariate Cox proportional hazard model, and Fine-Gray competing risk model were employed to examine the relationship between NPAR level and all-cause mortality and cardio-cerebrovascular mortality among PD patients. Furthermore, the ROC curve and calibration plots were utilized to compare the performance between NPAR and other conventional indicators.Results The mean follow-up period was 38.2 months. A total of 243 (30.1%) patients passed away, with 128 (52.7%) succumbing to cardio-cerebrovascular diseases. The mortality rates of the Middle and High NPAR groups were significantly greater than that of the Low NPAR group (p < 0.001), and NPAR was independently associated with all-cause mortality and cardio-cerebrovascular mortality. Receiver Operating Characteristic (ROC) analysis indicated that the Area Under the Curve (AUC) of NPAR (0.714) was significantly superior to those of C-reactive protein (CRP) (0.597), neutrophil to lymphocyte ratio (NLR) (0.589), C-reactive protein to albumin ratio (CAR) (0.698) and platelet to lymphocyte ratio (PLR) (0.533).Conclusion NPAR served as an independent predictive marker for all-cause mortality and cardio-cerebrovascular mortality in PD patients. Moreover, NPAR demonstrated superior predictive potential compared to CRP, CAR, NLR, and PLR.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2294149Peritoneal dialysisneutrophilserum albuminpercentage-to-albumin ratio (NPAR;)prognosis |
| spellingShingle | Mingfan Xu Jingjia Huan Lujie Zhu Jiachun Xu Kai Song The neutrophil percentage-to-albumin ratio is an independent risk factor for poor prognosis in peritoneal dialysis patients Renal Failure Peritoneal dialysis neutrophil serum albumin percentage-to-albumin ratio (NPAR;) prognosis |
| title | The neutrophil percentage-to-albumin ratio is an independent risk factor for poor prognosis in peritoneal dialysis patients |
| title_full | The neutrophil percentage-to-albumin ratio is an independent risk factor for poor prognosis in peritoneal dialysis patients |
| title_fullStr | The neutrophil percentage-to-albumin ratio is an independent risk factor for poor prognosis in peritoneal dialysis patients |
| title_full_unstemmed | The neutrophil percentage-to-albumin ratio is an independent risk factor for poor prognosis in peritoneal dialysis patients |
| title_short | The neutrophil percentage-to-albumin ratio is an independent risk factor for poor prognosis in peritoneal dialysis patients |
| title_sort | neutrophil percentage to albumin ratio is an independent risk factor for poor prognosis in peritoneal dialysis patients |
| topic | Peritoneal dialysis neutrophil serum albumin percentage-to-albumin ratio (NPAR;) prognosis |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2294149 |
| work_keys_str_mv | AT mingfanxu theneutrophilpercentagetoalbuminratioisanindependentriskfactorforpoorprognosisinperitonealdialysispatients AT jingjiahuan theneutrophilpercentagetoalbuminratioisanindependentriskfactorforpoorprognosisinperitonealdialysispatients AT lujiezhu theneutrophilpercentagetoalbuminratioisanindependentriskfactorforpoorprognosisinperitonealdialysispatients AT jiachunxu theneutrophilpercentagetoalbuminratioisanindependentriskfactorforpoorprognosisinperitonealdialysispatients AT kaisong theneutrophilpercentagetoalbuminratioisanindependentriskfactorforpoorprognosisinperitonealdialysispatients AT mingfanxu neutrophilpercentagetoalbuminratioisanindependentriskfactorforpoorprognosisinperitonealdialysispatients AT jingjiahuan neutrophilpercentagetoalbuminratioisanindependentriskfactorforpoorprognosisinperitonealdialysispatients AT lujiezhu neutrophilpercentagetoalbuminratioisanindependentriskfactorforpoorprognosisinperitonealdialysispatients AT jiachunxu neutrophilpercentagetoalbuminratioisanindependentriskfactorforpoorprognosisinperitonealdialysispatients AT kaisong neutrophilpercentagetoalbuminratioisanindependentriskfactorforpoorprognosisinperitonealdialysispatients |