Mechanochemically‐Assisted Passerini Reactions: A Practical and Convenient Method for the Synthesis of Novel α‐Acyloxycarboxamide Derivatives

Mechanochemically‐Assisted Passerini Reactions: A Practical and Convenient Method for the Synthesis of Novel α‐Acyloxycarboxamide Derivatives

Abstract A carboxylic acid, an aldehyde, and an isonitrile were combined in a single step (Passerini reaction) under mechanochemical activation to produce several α‐acyloxycarboxamide derivatives in high to excellent yields within 15 min of milling. Mechanochemistry, when combined with the diversity...

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Bibliographic Details
Main Authors: Dr. Sodeeq Aderotimi Salami, Justin Bazibuhe Safari, Dr. Vincent J. Smith, Prof. Dr. Rui W. M. Krause
Format: Article
Language:English
Published: Wiley-VCH 2023-05-01
Series:ChemistryOpen
Subjects:
α-acyloxycarboxamide
liquid-assisted grinding
mechanochemistry
Passerini reaction
silica sulfuric acid
Online Access:https://doi.org/10.1002/open.202200268

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