EFFICACY OF DIFFERENT TACTICS FOR INITIAL ANTIHYPERTENSIVE THERAPY
<p><strong>Aim.</strong> To evaluate different tactics of initial antihypertensive therapy.</p><p><strong>Material and Methods.</strong> 120 patients with mild-to-moderate arterial hypertension were included and randomized into three groups: “A”, “B”, and “C...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2015-12-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | http://www.rpcardio.ru/jour/article/view/380 |
| _version_ | 1797706257801412608 |
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| author | O. A. Pleyko A. O. Konrady |
| author_facet | O. A. Pleyko A. O. Konrady |
| author_sort | O. A. Pleyko |
| collection | DOAJ |
| description | <p><strong>Aim.</strong> To evaluate different tactics of initial antihypertensive therapy.</p><p><strong>Material and Methods.</strong> 120 patients with mild-to-moderate arterial hypertension were included and randomized into three groups: “A”, “B”, and “C”. 5 drugs from the main antihypertensive classes were used: indapamide, bisoprolol, amlodipine, fosinopril, and rilmenidine as well as fixed drug combination of fosinopril and hydrochlorothiazide. Patients included in group “A” received initial therapy according to individual leading pathogenic variant of hypertension. Patients from group “B” received standard stepped antihypertensive therapy with gradual dose increase and further addition of second (third) drug. Patients in group “C” were immediately administrated fixed drug combination and later added other drugs. Visits were scheduled after 2, 4, 6, 8, 10, etc weeks of treatment up to achievement of target blood pressure (BP).</p><p><strong>Results.</strong> In group “A” 33 patients (82,5%) achieved target BP after 6 visits, in group “B” - 37 patients (92,5%) after 8 visits and in group “C” - 100% of patents after 6 visits. Thus, in group “C” there was less number of visits and respectively lower number of therapy changes in order to achieve target BP. No significant discrepancies between group “A” and “B” were observed.</p><p><strong>Conclusion.</strong> Tactics of initial antihypertensive therapy with usage of fixed drug combination results in more effective and fast achievement of target BP.</p> |
| first_indexed | 2024-03-12T05:48:36Z |
| format | Article |
| id | doaj.art-7707f2ff077a46d1b7559900d2a7889c |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-03-12T05:48:36Z |
| publishDate | 2015-12-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-7707f2ff077a46d1b7559900d2a7889c2023-09-03T05:23:37ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532015-12-0131212710.1234/1819-6446-2007-1-21-27380EFFICACY OF DIFFERENT TACTICS FOR INITIAL ANTIHYPERTENSIVE THERAPYO. A. Pleyko0A. O. Konrady1Калининградская областная больницаФедеральный центр сердца, крови и эндокринологии им. В. А. Алмазова, Росздрав, Санкт-Петербург<p><strong>Aim.</strong> To evaluate different tactics of initial antihypertensive therapy.</p><p><strong>Material and Methods.</strong> 120 patients with mild-to-moderate arterial hypertension were included and randomized into three groups: “A”, “B”, and “C”. 5 drugs from the main antihypertensive classes were used: indapamide, bisoprolol, amlodipine, fosinopril, and rilmenidine as well as fixed drug combination of fosinopril and hydrochlorothiazide. Patients included in group “A” received initial therapy according to individual leading pathogenic variant of hypertension. Patients from group “B” received standard stepped antihypertensive therapy with gradual dose increase and further addition of second (third) drug. Patients in group “C” were immediately administrated fixed drug combination and later added other drugs. Visits were scheduled after 2, 4, 6, 8, 10, etc weeks of treatment up to achievement of target blood pressure (BP).</p><p><strong>Results.</strong> In group “A” 33 patients (82,5%) achieved target BP after 6 visits, in group “B” - 37 patients (92,5%) after 8 visits and in group “C” - 100% of patents after 6 visits. Thus, in group “C” there was less number of visits and respectively lower number of therapy changes in order to achieve target BP. No significant discrepancies between group “A” and “B” were observed.</p><p><strong>Conclusion.</strong> Tactics of initial antihypertensive therapy with usage of fixed drug combination results in more effective and fast achievement of target BP.</p>http://www.rpcardio.ru/jour/article/view/380артериальная гипертензиямонотерапиякомбинированная терапия |
| spellingShingle | O. A. Pleyko A. O. Konrady EFFICACY OF DIFFERENT TACTICS FOR INITIAL ANTIHYPERTENSIVE THERAPY Рациональная фармакотерапия в кардиологии артериальная гипертензия монотерапия комбинированная терапия |
| title | EFFICACY OF DIFFERENT TACTICS FOR INITIAL ANTIHYPERTENSIVE THERAPY |
| title_full | EFFICACY OF DIFFERENT TACTICS FOR INITIAL ANTIHYPERTENSIVE THERAPY |
| title_fullStr | EFFICACY OF DIFFERENT TACTICS FOR INITIAL ANTIHYPERTENSIVE THERAPY |
| title_full_unstemmed | EFFICACY OF DIFFERENT TACTICS FOR INITIAL ANTIHYPERTENSIVE THERAPY |
| title_short | EFFICACY OF DIFFERENT TACTICS FOR INITIAL ANTIHYPERTENSIVE THERAPY |
| title_sort | efficacy of different tactics for initial antihypertensive therapy |
| topic | артериальная гипертензия монотерапия комбинированная терапия |
| url | http://www.rpcardio.ru/jour/article/view/380 |
| work_keys_str_mv | AT oapleyko efficacyofdifferenttacticsforinitialantihypertensivetherapy AT aokonrady efficacyofdifferenttacticsforinitialantihypertensivetherapy |