Immunohistochemical Analysis of 1.25-dihydroxyvitamin D3 Receptor Expression in Endometrial Cancer
Objective:This study aimed to immunohistochemically investigate the expression of 1.25-dihydroxyvitamin-D3-receptors (VDR) in benign and malignant lesions of the endometrial tissue.Method:The cases were divided into two groups as benign (n=10) and endometrioid adenocarcinoma (n=17) according to thei...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2021-06-01
|
| Series: | Bagcilar Medical Bulletin |
| Subjects: | |
| Online Access: |
http://behmedicalbulletin.org/archives/archive-detail/article-preview/mmunohistochemical-analysis-of-125-dihydroxyvitami/44171
|
| _version_ | 1828018458700283904 |
|---|---|
| author | Nesibe Kahraman Çetin Özgür Deniz Turan |
| author_facet | Nesibe Kahraman Çetin Özgür Deniz Turan |
| author_sort | Nesibe Kahraman Çetin |
| collection | DOAJ |
| description | Objective:This study aimed to immunohistochemically investigate the expression of 1.25-dihydroxyvitamin-D3-receptors (VDR) in benign and malignant lesions of the endometrial tissue.Method:The cases were divided into two groups as benign (n=10) and endometrioid adenocarcinoma (n=17) according to their endometrial pathology results. The expression of VDR was examined by immunohistochemical method in endometrial tissues of participants (n=27). Then, VDR expression levels were compared between the groups. The intensity of expression, extent of staining and overall scores were determined for the semi-quantitative evaluation of VDR expression. Demographic data of the patients were also recorded.Results:There was no significant difference between the groups in terms of demographic data (p>0.05) except age (p<0.001). VDR expression level in the malignant group was significantly higher than in the benign group (p<0.001). It was observed that when the tumor grade increased, the expression level of VDR also increased significantly (r=0.888, p<0.001). Similarly, VDR expression increased significantly as the stage progressed (r=0.639, p=0.006) but there was no statistically significant correlation between tumor size (p=0.645), estrogen receptor positivity, PR positivity and presence of lymphovascular invasion on VDR expression (p>0.05).Conclusion:The expression of VDR was increased in endometrial cancer when compared to normal endometrial tissue. As the tumor behavior became aggressive, VDR expression also increased. As a result, increased VDR level may be associated with endometrial cancer development and stage of disease. |
| first_indexed | 2024-04-10T11:04:32Z |
| format | Article |
| id | doaj.art-770991c277774cec9577e6dc16b232c1 |
| institution | Directory Open Access Journal |
| issn | 2547-9431 |
| language | English |
| last_indexed | 2024-04-10T11:04:32Z |
| publishDate | 2021-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Bagcilar Medical Bulletin |
| spelling | doaj.art-770991c277774cec9577e6dc16b232c12023-02-15T16:19:30ZengGalenos YayineviBagcilar Medical Bulletin2547-94312021-06-016214214710.4274/BMB.galenos.2021.01.0113049054Immunohistochemical Analysis of 1.25-dihydroxyvitamin D3 Receptor Expression in Endometrial CancerNesibe Kahraman Çetin0Özgür Deniz Turan1 Adnan Menderes University Faculty of Medicine, Department of Pathology, Aydın, Turkey Adnan Menderes University Faculty of Medicine, Department of Obstetrics and Gynecology, Aydın, Turkey Objective:This study aimed to immunohistochemically investigate the expression of 1.25-dihydroxyvitamin-D3-receptors (VDR) in benign and malignant lesions of the endometrial tissue.Method:The cases were divided into two groups as benign (n=10) and endometrioid adenocarcinoma (n=17) according to their endometrial pathology results. The expression of VDR was examined by immunohistochemical method in endometrial tissues of participants (n=27). Then, VDR expression levels were compared between the groups. The intensity of expression, extent of staining and overall scores were determined for the semi-quantitative evaluation of VDR expression. Demographic data of the patients were also recorded.Results:There was no significant difference between the groups in terms of demographic data (p>0.05) except age (p<0.001). VDR expression level in the malignant group was significantly higher than in the benign group (p<0.001). It was observed that when the tumor grade increased, the expression level of VDR also increased significantly (r=0.888, p<0.001). Similarly, VDR expression increased significantly as the stage progressed (r=0.639, p=0.006) but there was no statistically significant correlation between tumor size (p=0.645), estrogen receptor positivity, PR positivity and presence of lymphovascular invasion on VDR expression (p>0.05).Conclusion:The expression of VDR was increased in endometrial cancer when compared to normal endometrial tissue. As the tumor behavior became aggressive, VDR expression also increased. As a result, increased VDR level may be associated with endometrial cancer development and stage of disease. http://behmedicalbulletin.org/archives/archive-detail/article-preview/mmunohistochemical-analysis-of-125-dihydroxyvitami/44171 endometrial cancervitamin dvitamin d receptor |
| spellingShingle | Nesibe Kahraman Çetin Özgür Deniz Turan Immunohistochemical Analysis of 1.25-dihydroxyvitamin D3 Receptor Expression in Endometrial Cancer Bagcilar Medical Bulletin endometrial cancer vitamin d vitamin d receptor |
| title | Immunohistochemical Analysis of 1.25-dihydroxyvitamin D3 Receptor Expression in Endometrial Cancer |
| title_full | Immunohistochemical Analysis of 1.25-dihydroxyvitamin D3 Receptor Expression in Endometrial Cancer |
| title_fullStr | Immunohistochemical Analysis of 1.25-dihydroxyvitamin D3 Receptor Expression in Endometrial Cancer |
| title_full_unstemmed | Immunohistochemical Analysis of 1.25-dihydroxyvitamin D3 Receptor Expression in Endometrial Cancer |
| title_short | Immunohistochemical Analysis of 1.25-dihydroxyvitamin D3 Receptor Expression in Endometrial Cancer |
| title_sort | immunohistochemical analysis of 1 25 dihydroxyvitamin d3 receptor expression in endometrial cancer |
| topic | endometrial cancer vitamin d vitamin d receptor |
| url |
http://behmedicalbulletin.org/archives/archive-detail/article-preview/mmunohistochemical-analysis-of-125-dihydroxyvitami/44171
|
| work_keys_str_mv | AT nesibekahramancetin immunohistochemicalanalysisof125dihydroxyvitamind3receptorexpressioninendometrialcancer AT ozgurdenizturan immunohistochemicalanalysisof125dihydroxyvitamind3receptorexpressioninendometrialcancer |