Mechanics of gelatin-based hydrogels during finite strain tension, compression and shear
Introduction: Among the biopolymers used to make hydrogels, gelatin is very attractive due to its biocompatibility, biodegradability and versatile physico-chemical properties. A proper and complete characterization of the mechanical behavior of these hydrogels is critical to evaluate the relevance o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1094197/full |
| _version_ | 1797955354662797312 |
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| author | Hamid Yousefi-Mashouf Hamid Yousefi-Mashouf Lucie Bailly Laurent Orgéas Nathalie Henrich Bernardoni |
| author_facet | Hamid Yousefi-Mashouf Hamid Yousefi-Mashouf Lucie Bailly Laurent Orgéas Nathalie Henrich Bernardoni |
| author_sort | Hamid Yousefi-Mashouf |
| collection | DOAJ |
| description | Introduction: Among the biopolymers used to make hydrogels, gelatin is very attractive due to its biocompatibility, biodegradability and versatile physico-chemical properties. A proper and complete characterization of the mechanical behavior of these hydrogels is critical to evaluate the relevance of one formulation over another for a targeted application, and to optimise their processing route accordingly.Methods: In this work, we manufactured neat gelatin and gelatin covalently cross-linked with glutaraldehyde at various concentrations, yielding to hydrogels with tunable mechanical properties that we characterized under finite strain, cyclic tension, compression and shear loadings.Results and Discussion: The role of both the chemical formulation and the kinematical path on the mechanical performances of the gels is highlighted. As an opening towards biomedical applications, the properties of the gels are confronted to those of native soft tissues particularly complicated to restore, the human vocal folds. A specific cross-linked hydrogel is selected to mimic vocal-fold fibrous tissues. |
| first_indexed | 2024-04-10T23:31:48Z |
| format | Article |
| id | doaj.art-770a790f75834bd39ccbcb7a777631f2 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-10T23:31:48Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-770a790f75834bd39ccbcb7a777631f22023-01-12T05:30:19ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-01-011010.3389/fbioe.2022.10941971094197Mechanics of gelatin-based hydrogels during finite strain tension, compression and shearHamid Yousefi-Mashouf0Hamid Yousefi-Mashouf1Lucie Bailly2Laurent Orgéas3Nathalie Henrich Bernardoni4University Grenoble Alpes, Centre National de la Recherche Scientifique (CNRS), Grenoble INP, 3SR, Grenoble, FranceUniversity Grenoble Alpes, Centre National de la Recherche Scientifique (CNRS), Grenoble INP, GIPSA-lab, Grenoble, FranceUniversity Grenoble Alpes, Centre National de la Recherche Scientifique (CNRS), Grenoble INP, 3SR, Grenoble, FranceUniversity Grenoble Alpes, Centre National de la Recherche Scientifique (CNRS), Grenoble INP, 3SR, Grenoble, FranceUniversity Grenoble Alpes, Centre National de la Recherche Scientifique (CNRS), Grenoble INP, GIPSA-lab, Grenoble, FranceIntroduction: Among the biopolymers used to make hydrogels, gelatin is very attractive due to its biocompatibility, biodegradability and versatile physico-chemical properties. A proper and complete characterization of the mechanical behavior of these hydrogels is critical to evaluate the relevance of one formulation over another for a targeted application, and to optimise their processing route accordingly.Methods: In this work, we manufactured neat gelatin and gelatin covalently cross-linked with glutaraldehyde at various concentrations, yielding to hydrogels with tunable mechanical properties that we characterized under finite strain, cyclic tension, compression and shear loadings.Results and Discussion: The role of both the chemical formulation and the kinematical path on the mechanical performances of the gels is highlighted. As an opening towards biomedical applications, the properties of the gels are confronted to those of native soft tissues particularly complicated to restore, the human vocal folds. A specific cross-linked hydrogel is selected to mimic vocal-fold fibrous tissues.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1094197/fullcovalently cross-linked hydrogelgelatinglutaraldehydetunable mechanical propertiesfinite strainsvocal folds |
| spellingShingle | Hamid Yousefi-Mashouf Hamid Yousefi-Mashouf Lucie Bailly Laurent Orgéas Nathalie Henrich Bernardoni Mechanics of gelatin-based hydrogels during finite strain tension, compression and shear Frontiers in Bioengineering and Biotechnology covalently cross-linked hydrogel gelatin glutaraldehyde tunable mechanical properties finite strains vocal folds |
| title | Mechanics of gelatin-based hydrogels during finite strain tension, compression and shear |
| title_full | Mechanics of gelatin-based hydrogels during finite strain tension, compression and shear |
| title_fullStr | Mechanics of gelatin-based hydrogels during finite strain tension, compression and shear |
| title_full_unstemmed | Mechanics of gelatin-based hydrogels during finite strain tension, compression and shear |
| title_short | Mechanics of gelatin-based hydrogels during finite strain tension, compression and shear |
| title_sort | mechanics of gelatin based hydrogels during finite strain tension compression and shear |
| topic | covalently cross-linked hydrogel gelatin glutaraldehyde tunable mechanical properties finite strains vocal folds |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1094197/full |
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