Effects of dietary supplementation with N-acetyl cysteine on antioxidant capacities and the expression of inflammatory cytokines in weaned piglets
The present study was conducted to investigate the effects of N-acetylcysteine (NAC) on antioxidant capacities and the expression of inflammatory cytokines in weaned piglets. In total, 15 litters, containing 150 14-day-old piglets, were divided, by litter, into suckling (control), weaning and NAC gr...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2016-10-01
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| Series: | Italian Journal of Animal Science |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/1828051X.2016.1222244 |
| _version_ | 1828863596015124480 |
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| author | Qi Guo Xuan Cai Congcong Xu Zhen Luo Yongshuai Sheng Jian Bao Xiaolian Chen Jianxiong Xu |
| author_facet | Qi Guo Xuan Cai Congcong Xu Zhen Luo Yongshuai Sheng Jian Bao Xiaolian Chen Jianxiong Xu |
| author_sort | Qi Guo |
| collection | DOAJ |
| description | The present study was conducted to investigate the effects of N-acetylcysteine (NAC) on antioxidant capacities and the expression of inflammatory cytokines in weaned piglets. In total, 15 litters, containing 150 14-day-old piglets, were divided, by litter, into suckling (control), weaning and NAC groups. Thus, there were five litters per group. Compared with the suckling group, the weaning group had increased (p < .05) malondialdehyde (MDA), nitric oxide (NO), hydrogen peroxide (H2O2) and interleukin (IL)-6 contents in their serum and pro-inflammatory cytokine IL-6 and IL-1β expression levels in the jejunum, while they had decreased superoxide dismutase (SOD) (p = .055) and glutathione peroxidase (GSH-Px) (p = .057) activities, as well as IL-4 (p < .05) concentrations in their serum and I-κBα expression (p < .05) in their jejunum. Dietary supplementation with NAC had improved (p < .05) antioxidant status in serum and increased (p < .05) levels of IL-4 but decreased (p < .05) mRNA expression levels and concentrations of IL-6 and IL-1β. Meanwhile, the I-κBα expression level in the jejunum of the NAC-treated group increased (p < .05) compared with the weaning group. In conclusion, weaning resulted in oxidative stress, and dietary supplementation with NAC could increase the antioxidant capacities, while decreasing the jejunal expression of inflammatory cytokines in weaned piglets. |
| first_indexed | 2024-12-13T03:47:28Z |
| format | Article |
| id | doaj.art-770b8b6b806041b7b99e7873ae5b24b9 |
| institution | Directory Open Access Journal |
| issn | 1828-051X |
| language | English |
| last_indexed | 2024-12-13T03:47:28Z |
| publishDate | 2016-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Italian Journal of Animal Science |
| spelling | doaj.art-770b8b6b806041b7b99e7873ae5b24b92022-12-22T00:00:48ZengTaylor & Francis GroupItalian Journal of Animal Science1828-051X2016-10-0115463464110.1080/1828051X.2016.12222441222244Effects of dietary supplementation with N-acetyl cysteine on antioxidant capacities and the expression of inflammatory cytokines in weaned pigletsQi Guo0Xuan Cai1Congcong Xu2Zhen Luo3Yongshuai Sheng4Jian Bao5Xiaolian Chen6Jianxiong Xu7Shanghai Jiao Tong UniversityShanghai Jiao Tong UniversityShanghai Jiao Tong UniversityShanghai Jiao Tong UniversityShanghai Jiao Tong UniversityShanghai Jiao Tong UniversityJiangxi Academy of Agricultural SciencesShanghai Jiao Tong UniversityThe present study was conducted to investigate the effects of N-acetylcysteine (NAC) on antioxidant capacities and the expression of inflammatory cytokines in weaned piglets. In total, 15 litters, containing 150 14-day-old piglets, were divided, by litter, into suckling (control), weaning and NAC groups. Thus, there were five litters per group. Compared with the suckling group, the weaning group had increased (p < .05) malondialdehyde (MDA), nitric oxide (NO), hydrogen peroxide (H2O2) and interleukin (IL)-6 contents in their serum and pro-inflammatory cytokine IL-6 and IL-1β expression levels in the jejunum, while they had decreased superoxide dismutase (SOD) (p = .055) and glutathione peroxidase (GSH-Px) (p = .057) activities, as well as IL-4 (p < .05) concentrations in their serum and I-κBα expression (p < .05) in their jejunum. Dietary supplementation with NAC had improved (p < .05) antioxidant status in serum and increased (p < .05) levels of IL-4 but decreased (p < .05) mRNA expression levels and concentrations of IL-6 and IL-1β. Meanwhile, the I-κBα expression level in the jejunum of the NAC-treated group increased (p < .05) compared with the weaning group. In conclusion, weaning resulted in oxidative stress, and dietary supplementation with NAC could increase the antioxidant capacities, while decreasing the jejunal expression of inflammatory cytokines in weaned piglets.http://dx.doi.org/10.1080/1828051X.2016.1222244Antioxidant capacitiesinflammatory cytokinesN-acetyl cysteineweanedpiglets |
| spellingShingle | Qi Guo Xuan Cai Congcong Xu Zhen Luo Yongshuai Sheng Jian Bao Xiaolian Chen Jianxiong Xu Effects of dietary supplementation with N-acetyl cysteine on antioxidant capacities and the expression of inflammatory cytokines in weaned piglets Italian Journal of Animal Science Antioxidant capacities inflammatory cytokines N-acetyl cysteine weaned piglets |
| title | Effects of dietary supplementation with N-acetyl cysteine on antioxidant capacities and the expression of inflammatory cytokines in weaned piglets |
| title_full | Effects of dietary supplementation with N-acetyl cysteine on antioxidant capacities and the expression of inflammatory cytokines in weaned piglets |
| title_fullStr | Effects of dietary supplementation with N-acetyl cysteine on antioxidant capacities and the expression of inflammatory cytokines in weaned piglets |
| title_full_unstemmed | Effects of dietary supplementation with N-acetyl cysteine on antioxidant capacities and the expression of inflammatory cytokines in weaned piglets |
| title_short | Effects of dietary supplementation with N-acetyl cysteine on antioxidant capacities and the expression of inflammatory cytokines in weaned piglets |
| title_sort | effects of dietary supplementation with n acetyl cysteine on antioxidant capacities and the expression of inflammatory cytokines in weaned piglets |
| topic | Antioxidant capacities inflammatory cytokines N-acetyl cysteine weaned piglets |
| url | http://dx.doi.org/10.1080/1828051X.2016.1222244 |
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