Correlations of forced oscillometric bronchodilator response with airway inflammation and disease duration in asthma
Abstract Introduction Airway resistance and reactance, measured by forced oscillometry, are used to measure the airway obstruction in patients with asthma. Objectives This study aimed to investigate the oscillometric bronchodilator responses in treated and untreated asthma and evaluate its associati...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | The Clinical Respiratory Journal |
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| Online Access: | https://doi.org/10.1111/crj.13268 |
| _version_ | 1811182540679020544 |
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| author | Naoko Higaki Hiroshi Iwamoto Kakuhiro Yamaguchi Shinjiro Sakamoto Yasushi Horimasu Takeshi Masuda Shintaro Miyamoto Taku Nakashima Shinichiro Ohshimo Kazunori Fujitaka Hironobu Hamada Noboru Hattori |
| author_facet | Naoko Higaki Hiroshi Iwamoto Kakuhiro Yamaguchi Shinjiro Sakamoto Yasushi Horimasu Takeshi Masuda Shintaro Miyamoto Taku Nakashima Shinichiro Ohshimo Kazunori Fujitaka Hironobu Hamada Noboru Hattori |
| author_sort | Naoko Higaki |
| collection | DOAJ |
| description | Abstract Introduction Airway resistance and reactance, measured by forced oscillometry, are used to measure the airway obstruction in patients with asthma. Objectives This study aimed to investigate the oscillometric bronchodilator responses in treated and untreated asthma and evaluate its association with airway inflammation and disease duration. Materials and methods This study included 30 nonsmoking patients with mild to moderate treated asthma, 25 patients with newly diagnosed untreated asthma and 29 control subjects. Spirometric and oscillometric measurements were performed before and after inhalation of 400 µg salbutamol. Disease duration was defined as the number of years since asthma diagnosis. Results At airway resistance of 5 Hz (R5) and 20 Hz (R20), bronchodilator responses in patients with untreated and treated asthma were greater than those in control subjects. In patients with untreated asthma, higher fractional exhaled nitric oxide concentration (FeNO) levels were strongly correlated with greater reversibility of R20 (rs = −0.621, P < 0.001). In patients with treated asthma, there was no significant association between FeNO and oscillometric reversibility, whereas longer disease duration was significantly associated with lesser bronchodilator response at R20 (rs = 0.441, P < 0.05). Treated asthma patients with longer disease duration (≥10 years) showed significantly higher post‐bronchodilator R5 and R20 than the treated asthma patients with shorter disease duration (<10 years). Conclusion The present study provides further evidence of an association between airway inflammation and variable airway obstruction in asthma patients and indicates that long‐term disease duration could be related to poorly reversible airway resistance in patients with mild to moderate asthma. |
| first_indexed | 2024-04-11T09:33:19Z |
| format | Article |
| id | doaj.art-770d36659d654ce3ad13de0e6e58c6e1 |
| institution | Directory Open Access Journal |
| issn | 1752-6981 1752-699X |
| language | English |
| last_indexed | 2024-04-11T09:33:19Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Clinical Respiratory Journal |
| spelling | doaj.art-770d36659d654ce3ad13de0e6e58c6e12022-12-22T04:31:47ZengWileyThe Clinical Respiratory Journal1752-69811752-699X2021-01-01151485510.1111/crj.13268Correlations of forced oscillometric bronchodilator response with airway inflammation and disease duration in asthmaNaoko Higaki0Hiroshi Iwamoto1Kakuhiro Yamaguchi2Shinjiro Sakamoto3Yasushi Horimasu4Takeshi Masuda5Shintaro Miyamoto6Taku Nakashima7Shinichiro Ohshimo8Kazunori Fujitaka9Hironobu Hamada10Noboru Hattori11Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Physical Analysis and Therapeutic Sciences, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanAbstract Introduction Airway resistance and reactance, measured by forced oscillometry, are used to measure the airway obstruction in patients with asthma. Objectives This study aimed to investigate the oscillometric bronchodilator responses in treated and untreated asthma and evaluate its association with airway inflammation and disease duration. Materials and methods This study included 30 nonsmoking patients with mild to moderate treated asthma, 25 patients with newly diagnosed untreated asthma and 29 control subjects. Spirometric and oscillometric measurements were performed before and after inhalation of 400 µg salbutamol. Disease duration was defined as the number of years since asthma diagnosis. Results At airway resistance of 5 Hz (R5) and 20 Hz (R20), bronchodilator responses in patients with untreated and treated asthma were greater than those in control subjects. In patients with untreated asthma, higher fractional exhaled nitric oxide concentration (FeNO) levels were strongly correlated with greater reversibility of R20 (rs = −0.621, P < 0.001). In patients with treated asthma, there was no significant association between FeNO and oscillometric reversibility, whereas longer disease duration was significantly associated with lesser bronchodilator response at R20 (rs = 0.441, P < 0.05). Treated asthma patients with longer disease duration (≥10 years) showed significantly higher post‐bronchodilator R5 and R20 than the treated asthma patients with shorter disease duration (<10 years). Conclusion The present study provides further evidence of an association between airway inflammation and variable airway obstruction in asthma patients and indicates that long‐term disease duration could be related to poorly reversible airway resistance in patients with mild to moderate asthma.https://doi.org/10.1111/crj.13268airway remodelingfractional exhaled nitric oxideimpulse oscillometryrespiratory reactancerespiratory resistancereversibility testing |
| spellingShingle | Naoko Higaki Hiroshi Iwamoto Kakuhiro Yamaguchi Shinjiro Sakamoto Yasushi Horimasu Takeshi Masuda Shintaro Miyamoto Taku Nakashima Shinichiro Ohshimo Kazunori Fujitaka Hironobu Hamada Noboru Hattori Correlations of forced oscillometric bronchodilator response with airway inflammation and disease duration in asthma The Clinical Respiratory Journal airway remodeling fractional exhaled nitric oxide impulse oscillometry respiratory reactance respiratory resistance reversibility testing |
| title | Correlations of forced oscillometric bronchodilator response with airway inflammation and disease duration in asthma |
| title_full | Correlations of forced oscillometric bronchodilator response with airway inflammation and disease duration in asthma |
| title_fullStr | Correlations of forced oscillometric bronchodilator response with airway inflammation and disease duration in asthma |
| title_full_unstemmed | Correlations of forced oscillometric bronchodilator response with airway inflammation and disease duration in asthma |
| title_short | Correlations of forced oscillometric bronchodilator response with airway inflammation and disease duration in asthma |
| title_sort | correlations of forced oscillometric bronchodilator response with airway inflammation and disease duration in asthma |
| topic | airway remodeling fractional exhaled nitric oxide impulse oscillometry respiratory reactance respiratory resistance reversibility testing |
| url | https://doi.org/10.1111/crj.13268 |
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