Effect of pantoprazole on I-R -induced myocardial injury in diabetic rats targeting inflammatory cytokine release and oxidative stress
Objective(s): To evaluate the pleiotropic potential and underlying mechanism of pantoprazole (PPZ) (common Proton Pump Inhibitors, PPIs) in type 2 diabetes mellitus (T2DM) -associated ischemia/reperfusion (I-R)-induced myocardial infarction which is still uncharted. Whereas some other PPIs have demo...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2021-05-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | https://ijbms.mums.ac.ir/article_17816_d055b68c0041507d8ba838e33821f779.pdf |
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| author | Gaurav Taneja Arun Sharma Deepa Khanna Satyendra Rajput |
| author_facet | Gaurav Taneja Arun Sharma Deepa Khanna Satyendra Rajput |
| author_sort | Gaurav Taneja |
| collection | DOAJ |
| description | Objective(s): To evaluate the pleiotropic potential and underlying mechanism of pantoprazole (PPZ) (common Proton Pump Inhibitors, PPIs) in type 2 diabetes mellitus (T2DM) -associated ischemia/reperfusion (I-R)-induced myocardial infarction which is still uncharted. Whereas some other PPIs have demonstrated their anti-diabetic, antioxidant, and anti-inflammatory potential. Materials and Methods: We evaluated the potential of coinciding treatment of PPZ (4 mg/kg/po/day for 8 weeks) in Wistar albino rats against STZ (50 mg/kg/IP) induced T2DM model and I-R provoked cardiac infarction model in diabetic and non-diabetic condition. Results: PPZ significantly inhibited the perturbed deviations in blood glucose concentration, HbA1c, C-peptide, plasma insulin, and ameliorated the lipid profile (dyslipidemia). PPZ protected myocardial tissue against lipid peroxidation by restoring the levels of serum TBARS and reduced NBT. The significant protective effects of PPZ were evident by ameliorating CKMB, LDH, cTnI, and myocardial oxidative stress in PPZ treated animals. Additionally, PPZ prominently reduced various proinflammatory cytokines release including TGF-β1, TNF-α, and IL-6. PPZ upsurges the bioavailability of nitrite/nitrate concentration which may pacify the impact of myocardial infarction in diabetic I-R injury. Conclusion: The consequences indicate that PPZ possesses a potent protective effect against diabetic I-R-induced myocardial infarction via suppressing oxidative stress, inflammation, and dyslipidemia-associated tissue damage. |
| first_indexed | 2024-12-19T12:59:47Z |
| format | Article |
| id | doaj.art-770dec8fe3494d77ae7fc437262ac17c |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-19T12:59:47Z |
| publishDate | 2021-05-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-770dec8fe3494d77ae7fc437262ac17c2022-12-21T20:20:16ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742021-05-0124561562210.22038/ijbms.2021.51624.1171417816Effect of pantoprazole on I-R -induced myocardial injury in diabetic rats targeting inflammatory cytokine release and oxidative stressGaurav Taneja0Arun Sharma1Deepa Khanna2Satyendra Rajput3Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Uttar Pradesh-201303, IndiaCardiovascular Division, Department of Pharmacology, Amity University Haryana, Gurugram-122413, IndiaRajendra Institute of Technology and Sciences (RITS), Sirsa, Haryana, IndiaDepartment of Pharmacology, Amity Institute of Pharmacy, Amity University, Uttar Pradesh-201303, IndiaObjective(s): To evaluate the pleiotropic potential and underlying mechanism of pantoprazole (PPZ) (common Proton Pump Inhibitors, PPIs) in type 2 diabetes mellitus (T2DM) -associated ischemia/reperfusion (I-R)-induced myocardial infarction which is still uncharted. Whereas some other PPIs have demonstrated their anti-diabetic, antioxidant, and anti-inflammatory potential. Materials and Methods: We evaluated the potential of coinciding treatment of PPZ (4 mg/kg/po/day for 8 weeks) in Wistar albino rats against STZ (50 mg/kg/IP) induced T2DM model and I-R provoked cardiac infarction model in diabetic and non-diabetic condition. Results: PPZ significantly inhibited the perturbed deviations in blood glucose concentration, HbA1c, C-peptide, plasma insulin, and ameliorated the lipid profile (dyslipidemia). PPZ protected myocardial tissue against lipid peroxidation by restoring the levels of serum TBARS and reduced NBT. The significant protective effects of PPZ were evident by ameliorating CKMB, LDH, cTnI, and myocardial oxidative stress in PPZ treated animals. Additionally, PPZ prominently reduced various proinflammatory cytokines release including TGF-β1, TNF-α, and IL-6. PPZ upsurges the bioavailability of nitrite/nitrate concentration which may pacify the impact of myocardial infarction in diabetic I-R injury. Conclusion: The consequences indicate that PPZ possesses a potent protective effect against diabetic I-R-induced myocardial infarction via suppressing oxidative stress, inflammation, and dyslipidemia-associated tissue damage.https://ijbms.mums.ac.ir/article_17816_d055b68c0041507d8ba838e33821f779.pdfcardiomyopathydiabetes mellitusinflammatory cytokinesmyocardial i/r insultoxidative stresspantoprazole |
| spellingShingle | Gaurav Taneja Arun Sharma Deepa Khanna Satyendra Rajput Effect of pantoprazole on I-R -induced myocardial injury in diabetic rats targeting inflammatory cytokine release and oxidative stress Iranian Journal of Basic Medical Sciences cardiomyopathy diabetes mellitus inflammatory cytokines myocardial i/r insult oxidative stress pantoprazole |
| title | Effect of pantoprazole on I-R -induced myocardial injury in diabetic rats targeting inflammatory cytokine release and oxidative stress |
| title_full | Effect of pantoprazole on I-R -induced myocardial injury in diabetic rats targeting inflammatory cytokine release and oxidative stress |
| title_fullStr | Effect of pantoprazole on I-R -induced myocardial injury in diabetic rats targeting inflammatory cytokine release and oxidative stress |
| title_full_unstemmed | Effect of pantoprazole on I-R -induced myocardial injury in diabetic rats targeting inflammatory cytokine release and oxidative stress |
| title_short | Effect of pantoprazole on I-R -induced myocardial injury in diabetic rats targeting inflammatory cytokine release and oxidative stress |
| title_sort | effect of pantoprazole on i r induced myocardial injury in diabetic rats targeting inflammatory cytokine release and oxidative stress |
| topic | cardiomyopathy diabetes mellitus inflammatory cytokines myocardial i/r insult oxidative stress pantoprazole |
| url | https://ijbms.mums.ac.ir/article_17816_d055b68c0041507d8ba838e33821f779.pdf |
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