Inferring longitudinal patterns of group B Streptococcus colonization during pregnancy
Summary: Maternal colonization by Group B Streptococcus (GBS) can lead to severe infection in neonates and has also been associated with prematurity and stillbirth. Better quantitative understanding of the trajectories of GBS carriage during pregnancy is essential for the design of informative epide...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223011008 |
| _version_ | 1797774552690851840 |
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| author | Bronner P. Gonçalves Onur Poyraz Proma Paul Joy E. Lawn |
| author_facet | Bronner P. Gonçalves Onur Poyraz Proma Paul Joy E. Lawn |
| author_sort | Bronner P. Gonçalves |
| collection | DOAJ |
| description | Summary: Maternal colonization by Group B Streptococcus (GBS) can lead to severe infection in neonates and has also been associated with prematurity and stillbirth. Better quantitative understanding of the trajectories of GBS carriage during pregnancy is essential for the design of informative epidemiological studies. Here, we describe analyses of published longitudinal data using Bayesian hidden Markov models, which involve the estimation of parameters related to the succession of latent states (infection status) and observations (culture positivity). In addition to quantifying infection acquisition and clearance probabilities, the statistical approach also suggests that for some longitudinal patterns of culture results, pregnant women were likely to have been GBS-colonized despite a negative diagnostic result. We believe this method, if used in future longitudinal studies of maternal GBS colonization, would improve our understanding of the pathologies linked to this bacterium and could also inform maternal GBS vaccine trial design. |
| first_indexed | 2024-03-12T22:22:44Z |
| format | Article |
| id | doaj.art-770decc959f14b458d093233c8a875ac |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T22:22:44Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-770decc959f14b458d093233c8a875ac2023-07-23T04:55:11ZengElsevieriScience2589-00422023-07-01267107023Inferring longitudinal patterns of group B Streptococcus colonization during pregnancyBronner P. Gonçalves0Onur Poyraz1Proma Paul2Joy E. Lawn3Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK; Maternal, Adolescent, Reproductive & Child Health Centre, London School of Hygiene & Tropical Medicine, London, UK; Department of Comparative Biomedical Sciences, School of Veterinary Medicine, University of Surrey, Guildford, UK; Corresponding authorDepartment of Computer Science, Aalto University School of Science, Aalto, FinlandDepartment of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK; Maternal, Adolescent, Reproductive & Child Health Centre, London School of Hygiene & Tropical Medicine, London, UKDepartment of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK; Maternal, Adolescent, Reproductive & Child Health Centre, London School of Hygiene & Tropical Medicine, London, UKSummary: Maternal colonization by Group B Streptococcus (GBS) can lead to severe infection in neonates and has also been associated with prematurity and stillbirth. Better quantitative understanding of the trajectories of GBS carriage during pregnancy is essential for the design of informative epidemiological studies. Here, we describe analyses of published longitudinal data using Bayesian hidden Markov models, which involve the estimation of parameters related to the succession of latent states (infection status) and observations (culture positivity). In addition to quantifying infection acquisition and clearance probabilities, the statistical approach also suggests that for some longitudinal patterns of culture results, pregnant women were likely to have been GBS-colonized despite a negative diagnostic result. We believe this method, if used in future longitudinal studies of maternal GBS colonization, would improve our understanding of the pathologies linked to this bacterium and could also inform maternal GBS vaccine trial design.http://www.sciencedirect.com/science/article/pii/S2589004223011008MicrobiologyStatistical computing |
| spellingShingle | Bronner P. Gonçalves Onur Poyraz Proma Paul Joy E. Lawn Inferring longitudinal patterns of group B Streptococcus colonization during pregnancy iScience Microbiology Statistical computing |
| title | Inferring longitudinal patterns of group B Streptococcus colonization during pregnancy |
| title_full | Inferring longitudinal patterns of group B Streptococcus colonization during pregnancy |
| title_fullStr | Inferring longitudinal patterns of group B Streptococcus colonization during pregnancy |
| title_full_unstemmed | Inferring longitudinal patterns of group B Streptococcus colonization during pregnancy |
| title_short | Inferring longitudinal patterns of group B Streptococcus colonization during pregnancy |
| title_sort | inferring longitudinal patterns of group b streptococcus colonization during pregnancy |
| topic | Microbiology Statistical computing |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223011008 |
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