Case report: First report of isolated central nervous system lymphoblastic crisis in a child with chronic myeloid leukemia on dasatinib therapy
Most children with chronic myeloid leukemia (CML) present with the chronic phase (CML-CP) at diagnosis, exhibiting an excellent treatment response to contemporary tyrosine kinase inhibitors (TKIs). However, despite TKI therapy, patients with CML-CP may progress to blastic crisis (BC). CML-BC rarely...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1122714/full |
| _version_ | 1797862038823763968 |
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| author | Suejung Jo Jae Won Yoo Seongkoo Kim Jae Wook Lee Soo-Ah Im Bin Cho Nack-Gyun Chung |
| author_facet | Suejung Jo Jae Won Yoo Seongkoo Kim Jae Wook Lee Soo-Ah Im Bin Cho Nack-Gyun Chung |
| author_sort | Suejung Jo |
| collection | DOAJ |
| description | Most children with chronic myeloid leukemia (CML) present with the chronic phase (CML-CP) at diagnosis, exhibiting an excellent treatment response to contemporary tyrosine kinase inhibitors (TKIs). However, despite TKI therapy, patients with CML-CP may progress to blastic crisis (BC). CML-BC rarely occurs in extramedullary sites, and isolated central nervous system (CNS) BC is an extremely rare condition. It may with present various neurologic symptoms that necessitates differential diagnosis from other causes such as TKI toxicity. Information on the diagnosis and treatment of this condition is lacking, as are well-established diagnostic criteria. Here, we report a case of isolated CNS lymphoblastic crisis in a child with CML-CP who was treated with dasatinib. The patient, an 8-year-old girl, was admitted owing to visual disturbance and severe headache. We highlight the importance of a CSF study for the differential diagnosis of CNS BC in patients with CML-CP who present with common neurologic symptoms during TKI therapy. |
| first_indexed | 2024-04-09T22:14:02Z |
| format | Article |
| id | doaj.art-7710407d0318446da1bb84709a145d62 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-09T22:14:02Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-7710407d0318446da1bb84709a145d622023-03-23T05:59:40ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-03-011310.3389/fonc.2023.11227141122714Case report: First report of isolated central nervous system lymphoblastic crisis in a child with chronic myeloid leukemia on dasatinib therapySuejung Jo0Jae Won Yoo1Seongkoo Kim2Jae Wook Lee3Soo-Ah Im4Bin Cho5Nack-Gyun Chung6Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaMost children with chronic myeloid leukemia (CML) present with the chronic phase (CML-CP) at diagnosis, exhibiting an excellent treatment response to contemporary tyrosine kinase inhibitors (TKIs). However, despite TKI therapy, patients with CML-CP may progress to blastic crisis (BC). CML-BC rarely occurs in extramedullary sites, and isolated central nervous system (CNS) BC is an extremely rare condition. It may with present various neurologic symptoms that necessitates differential diagnosis from other causes such as TKI toxicity. Information on the diagnosis and treatment of this condition is lacking, as are well-established diagnostic criteria. Here, we report a case of isolated CNS lymphoblastic crisis in a child with CML-CP who was treated with dasatinib. The patient, an 8-year-old girl, was admitted owing to visual disturbance and severe headache. We highlight the importance of a CSF study for the differential diagnosis of CNS BC in patients with CML-CP who present with common neurologic symptoms during TKI therapy.https://www.frontiersin.org/articles/10.3389/fonc.2023.1122714/fullpediatric chronic myeloid leukemiaisolated central nervous system blastic crisisDasatinibtyrosine kinase inhibitor induced optic neuropathycerebrospinal fluid study |
| spellingShingle | Suejung Jo Jae Won Yoo Seongkoo Kim Jae Wook Lee Soo-Ah Im Bin Cho Nack-Gyun Chung Case report: First report of isolated central nervous system lymphoblastic crisis in a child with chronic myeloid leukemia on dasatinib therapy Frontiers in Oncology pediatric chronic myeloid leukemia isolated central nervous system blastic crisis Dasatinib tyrosine kinase inhibitor induced optic neuropathy cerebrospinal fluid study |
| title | Case report: First report of isolated central nervous system lymphoblastic crisis in a child with chronic myeloid leukemia on dasatinib therapy |
| title_full | Case report: First report of isolated central nervous system lymphoblastic crisis in a child with chronic myeloid leukemia on dasatinib therapy |
| title_fullStr | Case report: First report of isolated central nervous system lymphoblastic crisis in a child with chronic myeloid leukemia on dasatinib therapy |
| title_full_unstemmed | Case report: First report of isolated central nervous system lymphoblastic crisis in a child with chronic myeloid leukemia on dasatinib therapy |
| title_short | Case report: First report of isolated central nervous system lymphoblastic crisis in a child with chronic myeloid leukemia on dasatinib therapy |
| title_sort | case report first report of isolated central nervous system lymphoblastic crisis in a child with chronic myeloid leukemia on dasatinib therapy |
| topic | pediatric chronic myeloid leukemia isolated central nervous system blastic crisis Dasatinib tyrosine kinase inhibitor induced optic neuropathy cerebrospinal fluid study |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1122714/full |
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