The Study of the Expression of <i>CGB1</i> and <i>CGB2</i> in Human Cancer Tissues
Human chorionic gonadotropin (hCG) is a well-known hormone produced by the trophoblast during pregnancy as well as by both trophoblastic and non-trophoblastic tumors. hCG is built from two subunits: α (hCGα) and β (hCGβ). The hormone-specific β subunit is encoded by six allelic genes: <i>CGB3&...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/11/9/1082 |
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| author | Piotr Białas Aleksandra Śliwa Anna Szczerba Anna Jankowska |
| author_facet | Piotr Białas Aleksandra Śliwa Anna Szczerba Anna Jankowska |
| author_sort | Piotr Białas |
| collection | DOAJ |
| description | Human chorionic gonadotropin (hCG) is a well-known hormone produced by the trophoblast during pregnancy as well as by both trophoblastic and non-trophoblastic tumors. hCG is built from two subunits: α (hCGα) and β (hCGβ). The hormone-specific β subunit is encoded by six allelic genes: <i>CGB3</i>, <i>CGB5</i>, <i>CGB6</i>, <i>CGB7</i>, <i>CGB8</i>, and <i>CGB9</i>, mapped to the 19q13.32 locus. This gene cluster also encompasses the <i>CGB1</i> and <i>CGB2</i> genes, which were originally considered to be pseudogenes, but as documented by several studies are transcriptionally active. Even though the protein products of these genes have not yet been identified, based on The Cancer Genome Atlas (TCGA) database analysis we showed that the mutual presence of <i>CGB1</i> and <i>CGB2</i> transcripts is a characteristic feature of cancers of different origin, including bladder urothelial carcinoma, cervical squamous cell carcinoma, esophageal carcinoma, head and neck squamous cell carcinoma, ovarian serous cystadenocarcinoma, lung squamous cell carcinoma, pancreatic adenocarcinoma, rectum adenocacinoma, testis germ cell tumors, thymoma, uterine corpus endometrial carcinoma and uterine carcinosarcoma. |
| first_indexed | 2024-03-10T16:16:24Z |
| format | Article |
| id | doaj.art-7714130aa38c4947a7354b93dd6afbc0 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T16:16:24Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-7714130aa38c4947a7354b93dd6afbc02023-11-20T14:00:33ZengMDPI AGGenes2073-44252020-09-01119108210.3390/genes11091082The Study of the Expression of <i>CGB1</i> and <i>CGB2</i> in Human Cancer TissuesPiotr Białas0Aleksandra Śliwa1Anna Szczerba2Anna Jankowska3Department of Cell Biology, Poznan University of Medical Sciences, Rokietnicka 5D, 60-806 Poznań, PolandDepartment of Cell Biology, Poznan University of Medical Sciences, Rokietnicka 5D, 60-806 Poznań, PolandDepartment of Cell Biology, Poznan University of Medical Sciences, Rokietnicka 5D, 60-806 Poznań, PolandDepartment of Cell Biology, Poznan University of Medical Sciences, Rokietnicka 5D, 60-806 Poznań, PolandHuman chorionic gonadotropin (hCG) is a well-known hormone produced by the trophoblast during pregnancy as well as by both trophoblastic and non-trophoblastic tumors. hCG is built from two subunits: α (hCGα) and β (hCGβ). The hormone-specific β subunit is encoded by six allelic genes: <i>CGB3</i>, <i>CGB5</i>, <i>CGB6</i>, <i>CGB7</i>, <i>CGB8</i>, and <i>CGB9</i>, mapped to the 19q13.32 locus. This gene cluster also encompasses the <i>CGB1</i> and <i>CGB2</i> genes, which were originally considered to be pseudogenes, but as documented by several studies are transcriptionally active. Even though the protein products of these genes have not yet been identified, based on The Cancer Genome Atlas (TCGA) database analysis we showed that the mutual presence of <i>CGB1</i> and <i>CGB2</i> transcripts is a characteristic feature of cancers of different origin, including bladder urothelial carcinoma, cervical squamous cell carcinoma, esophageal carcinoma, head and neck squamous cell carcinoma, ovarian serous cystadenocarcinoma, lung squamous cell carcinoma, pancreatic adenocarcinoma, rectum adenocacinoma, testis germ cell tumors, thymoma, uterine corpus endometrial carcinoma and uterine carcinosarcoma.https://www.mdpi.com/2073-4425/11/9/1082human chorionic gonadotropinTCGAcancerCGB1CGB2 |
| spellingShingle | Piotr Białas Aleksandra Śliwa Anna Szczerba Anna Jankowska The Study of the Expression of <i>CGB1</i> and <i>CGB2</i> in Human Cancer Tissues Genes human chorionic gonadotropin TCGA cancer CGB1 CGB2 |
| title | The Study of the Expression of <i>CGB1</i> and <i>CGB2</i> in Human Cancer Tissues |
| title_full | The Study of the Expression of <i>CGB1</i> and <i>CGB2</i> in Human Cancer Tissues |
| title_fullStr | The Study of the Expression of <i>CGB1</i> and <i>CGB2</i> in Human Cancer Tissues |
| title_full_unstemmed | The Study of the Expression of <i>CGB1</i> and <i>CGB2</i> in Human Cancer Tissues |
| title_short | The Study of the Expression of <i>CGB1</i> and <i>CGB2</i> in Human Cancer Tissues |
| title_sort | study of the expression of i cgb1 i and i cgb2 i in human cancer tissues |
| topic | human chorionic gonadotropin TCGA cancer CGB1 CGB2 |
| url | https://www.mdpi.com/2073-4425/11/9/1082 |
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