Polymyxin B Attenuates LPS-Induced Death but Aggravates Radiation-Induced Death via TLR4-Myd88-IL-6 Pathway

Polymyxin B Attenuates LPS-Induced Death but Aggravates Radiation-Induced Death via TLR4-Myd88-IL-6 Pathway

Background/Aims: Polymyxin B (PMB) is a cyclic cationic polypeptide antibiotic widely used to counteract the effects of endotoxin contamination, both in vitro and in vivo. Lipopolysaccharide (LPS) is an endotoxin that acts as a radiation protection factor. In this study, we focus on the role of PMB...

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Bibliographic Details
Main Authors: Ying Cheng, Jicong Du, Jiaqi Han, Weimin Sun, Fu Gao, Pei Zhang, Hainan Zhao, Ming Chen, Jianing Wang, Mingyu Wang, Suhe Dong, Ding Sun, Yandong Zhang, Jianguo Cui, Jianming Cai, Cong Liu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Radiation
TLR4
Myd88
IL-6
Polymyxin B
LPS
Online Access:http://www.karger.com/Article/FullText/478767

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