Related factors of perianal tissue infection in patients with malignant hematopathy: a meta-analysis
Objective To analyze the risk factors of perianal infection in patients with malignant hematopathy in order to provide theoretical basis for the prevention. Methods Case-control studies and cohort studies concerning the related factors or the main risk factors for perianal tissue infection in patien...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Third Military Medical University
2020-09-01
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| Series: | Di-san junyi daxue xuebao |
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| Online Access: | http://aammt.tmmu.edu.cn/Upload/rhtml/202005137.htm |
| _version_ | 1818902783278972928 |
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| author | CHEN Xiaoli FENG Yimei SUN Hengrui ZHANG Xi KONG Peiyan DU Xin |
| author_facet | CHEN Xiaoli FENG Yimei SUN Hengrui ZHANG Xi KONG Peiyan DU Xin |
| author_sort | CHEN Xiaoli |
| collection | DOAJ |
| description | Objective To analyze the risk factors of perianal infection in patients with malignant hematopathy in order to provide theoretical basis for the prevention. Methods Case-control studies and cohort studies concerning the related factors or the main risk factors for perianal tissue infection in patients with malignant hematopathy were retrieved from the indexed articles from PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure Database (CNKI), China Science and Technology Periodical Database (VIP), and Wanfan Database. Two evaluators independently retrieved and screened the literature, extracted the data, and made methodological quality assessment of the included literatures and cross-checked. Controversial issues were discussed and agreed by 3 evaluators together. Software Revman 5.3 was used for meta-analysis. A fixed-effect model or a random-effect model was used to combine odds ratio (OR) values and 95% confidence intervals (CI) to analyze each relevant risk factor, and sensitivity analysis was employed to assess the stability of the results. Results Eight literatures, containing a total of 1 857 cases were included for further analysis, including 272 cases (272/1 857, 14.6%) in the perianal infection group and 1 585 cases in the control group. The results of meta-analysis showed that age older than 50 years, irremission after chemotherapy, and the absolute count of neutrophils < 0.5×109/L, and acute myeloid leukemia were related to the formation of perianal infection in patients with hematopathy. There were no statistical difference in the incidence of perianal infection between male and female patients (P > 0.05). Conclusion The risk factors for perianal infection in patients with malignant hematologic disease are those aged over 50 years, unrelieved chemotherapy, and absolute value of neutrophils < 0.5×109/L and acute myeloid leukemia. |
| first_indexed | 2024-12-19T20:41:08Z |
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| id | doaj.art-771588e3339d449a93c6377b4f37d15f |
| institution | Directory Open Access Journal |
| issn | 1000-5404 |
| language | zho |
| last_indexed | 2024-12-19T20:41:08Z |
| publishDate | 2020-09-01 |
| publisher | Editorial Office of Journal of Third Military Medical University |
| record_format | Article |
| series | Di-san junyi daxue xuebao |
| spelling | doaj.art-771588e3339d449a93c6377b4f37d15f2022-12-21T20:06:24ZzhoEditorial Office of Journal of Third Military Medical UniversityDi-san junyi daxue xuebao1000-54042020-09-0142171763176810.16016/j.1000-5404.202005137Related factors of perianal tissue infection in patients with malignant hematopathy: a meta-analysisCHEN Xiaoli0FENG Yimei1SUN Hengrui2ZHANG Xi3KONG Peiyan4DU Xin5State Key Laboratory of Trauma, Burns and Combined Injury, Medical Center of Hematology, PLA Center for Hematology, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China State Key Laboratory of Trauma, Burns and Combined Injury, Medical Center of Hematology, PLA Center for Hematology, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China State Key Laboratory of Trauma, Burns and Combined Injury, Medical Center of Hematology, PLA Center for Hematology, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China State Key Laboratory of Trauma, Burns and Combined Injury, Medical Center of Hematology, PLA Center for Hematology, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China State Key Laboratory of Trauma, Burns and Combined Injury, Medical Center of Hematology, PLA Center for Hematology, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China State Key Laboratory of Trauma, Burns and Combined Injury, Medical Center of Hematology, PLA Center for Hematology, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China Objective To analyze the risk factors of perianal infection in patients with malignant hematopathy in order to provide theoretical basis for the prevention. Methods Case-control studies and cohort studies concerning the related factors or the main risk factors for perianal tissue infection in patients with malignant hematopathy were retrieved from the indexed articles from PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure Database (CNKI), China Science and Technology Periodical Database (VIP), and Wanfan Database. Two evaluators independently retrieved and screened the literature, extracted the data, and made methodological quality assessment of the included literatures and cross-checked. Controversial issues were discussed and agreed by 3 evaluators together. Software Revman 5.3 was used for meta-analysis. A fixed-effect model or a random-effect model was used to combine odds ratio (OR) values and 95% confidence intervals (CI) to analyze each relevant risk factor, and sensitivity analysis was employed to assess the stability of the results. Results Eight literatures, containing a total of 1 857 cases were included for further analysis, including 272 cases (272/1 857, 14.6%) in the perianal infection group and 1 585 cases in the control group. The results of meta-analysis showed that age older than 50 years, irremission after chemotherapy, and the absolute count of neutrophils < 0.5×109/L, and acute myeloid leukemia were related to the formation of perianal infection in patients with hematopathy. There were no statistical difference in the incidence of perianal infection between male and female patients (P > 0.05). Conclusion The risk factors for perianal infection in patients with malignant hematologic disease are those aged over 50 years, unrelieved chemotherapy, and absolute value of neutrophils < 0.5×109/L and acute myeloid leukemia.http://aammt.tmmu.edu.cn/Upload/rhtml/202005137.htmhematologic malignanciesleukemiaperianal infectionrisk factors |
| spellingShingle | CHEN Xiaoli FENG Yimei SUN Hengrui ZHANG Xi KONG Peiyan DU Xin Related factors of perianal tissue infection in patients with malignant hematopathy: a meta-analysis Di-san junyi daxue xuebao hematologic malignancies leukemia perianal infection risk factors |
| title | Related factors of perianal tissue infection in patients with malignant hematopathy: a meta-analysis |
| title_full | Related factors of perianal tissue infection in patients with malignant hematopathy: a meta-analysis |
| title_fullStr | Related factors of perianal tissue infection in patients with malignant hematopathy: a meta-analysis |
| title_full_unstemmed | Related factors of perianal tissue infection in patients with malignant hematopathy: a meta-analysis |
| title_short | Related factors of perianal tissue infection in patients with malignant hematopathy: a meta-analysis |
| title_sort | related factors of perianal tissue infection in patients with malignant hematopathy a meta analysis |
| topic | hematologic malignancies leukemia perianal infection risk factors |
| url | http://aammt.tmmu.edu.cn/Upload/rhtml/202005137.htm |
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