Neonatal inflammation via persistent TGF-β1 downregulation decreases GABAAR expression in basolateral amygdala leading to the imbalance of the local excitation-inhibition circuits and anxiety-like phenotype in adult mice

Neonatal inflammation via persistent TGF-β1 downregulation decreases GABAAR expression in basolateral amygdala leading to the imbalance of the local excitation-inhibition circuits and anxiety-like phenotype in adult mice

Neonatal inflammation can increase the risk of anxiety disorder in adulthood. The balance between glutamatergic excitatory and GABAergic inhibitory transmissions in the basolateral amygdala (BLA) plays a vital role in controlling anxiety state. Based on the reports that early-life inflammation had a...

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Bibliographic Details
Main Authors: Haiquan Zhong, Jing Rong, Yang Yang, Min Liang, Yingchun Li, Rong Zhou
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Neurobiology of Disease
Subjects:
Lipopolysaccharide
Developmental neurological disorder
Basolateral amygdala
GABAergic system
Cytokines
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122001371

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