Underlying mechanism and specific prevention of hemolysis-induced platelet activation

Underlying mechanism and specific prevention of hemolysis-induced platelet activation

Thromboembolic complications significantly impair the outcome of hemolytic disorders. We hypothesized that red cell adenosine diphosphate (ADP) release results in significant platelet activation in hemolysis and that this prothrombotic state can be prevented by inhibition of the ADP P2Y12 receptor....

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Bibliographic Details
Main Authors: Thomas Gremmel, Simone Fedrizzi, Günter Weigel, Beate Eichelberger, Simon Panzer
Format: Article
Language:English
Published: Taylor & Francis Group 2017-08-01
Series:Platelets
Subjects:
adp
hemolysis
platelet activation
p2y12inhibitors
Online Access:http://dx.doi.org/10.1080/09537104.2016.1240769

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