Both 3,3′,5-triiodothyronine and 3,5-diodo-L-thyronine Are Able to Repair Mitochondrial DNA Damage but by Different Mechanisms

Both 3,3′,5-triiodothyronine and 3,5-diodo-L-thyronine Are Able to Repair Mitochondrial DNA Damage but by Different Mechanisms

This study evaluated the effect of 3,5-diiodo-L-thyronine (T2) and 3,5,3′-triiodo-L-thyronine (T3) on rat liver mitochondrial DNA (mtDNA) oxidative damage and repair and to investigate their ability to induce protective effects against oxidative stress. Control rats, rats receiving a daily injection...

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Bibliographic Details
Main Authors: Federica Cioffi, Rosalba Senese, Giuseppe Petito, Pasquale Lasala, Pieter de Lange, Elena Silvestri, Assunta Lombardi, Maria Moreno, Fernando Goglia, Antonia Lanni
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Endocrinology
Subjects:
mitochondria
liver
mtDNA
oxidative damage
iodothyronines
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00216/full

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