Association of the Calcification Score of the Abdominal Aorta, Common Iliac, and Renal Arteries with Outcomes in Living Kidney Donors
Background: Vascular calcification is an ever-more-common finding in protocoled pre-transplant imaging in living kidney donors. We intended to explore whether a connection could be found between the Agatston calcification score, prior to kidney donation, and post-donation renal function. Methods: Th...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/9/3339 |
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| author | Luís Costa Ribeiro Manuela Almeida Jorge Malheiro Filipa Silva Diogo Nunes-Carneiro La Salete Martins Sofia Pedroso Miguel Silva-Ramos |
| author_facet | Luís Costa Ribeiro Manuela Almeida Jorge Malheiro Filipa Silva Diogo Nunes-Carneiro La Salete Martins Sofia Pedroso Miguel Silva-Ramos |
| author_sort | Luís Costa Ribeiro |
| collection | DOAJ |
| description | Background: Vascular calcification is an ever-more-common finding in protocoled pre-transplant imaging in living kidney donors. We intended to explore whether a connection could be found between the Agatston calcification score, prior to kidney donation, and post-donation renal function. Methods: This is a retrospective analysis of 156 living kidney donors who underwent living donor nephrectomy between January 2010 and December 2016. We quantified the total calcification score (TCaScore) by calculating the Agatston score for each vessel, abdominal aorta, common iliac, and renal arteries. Donors were placed into two different groups based on their TCaScore: <100 TCaScore group and ≥100 TCaScore group. The relationship between TCaScore, 1-year eGFR, proteinuria, and risk of 1 measurement of decreased renal function (eGFR < 60 mL/min/1.73 m<sup>2</sup>) over 5 years of follow-up was investigated. Results: The ≥100 TCaScore group consisted of 29 (19%) donors, with a median (interquartile range) calcification score of 164 (117–358). This group was significantly older, 56.7 ± 6.9 vs. 45.5 ± 10.6 (<i>p</i> < 0.001), had a higher average BMI (<i>p</i> < 0.019), and had a lower preoperative eGFR (<i>p</i> < 0.014). The 1-year eGFR was similarly diminished, 69.9 ± 15.7 vs. 76.3 ± 15.5 (<i>p</i> < 0.048), while also having an increased risk of decreased renal function during the follow-up, 22% vs. 48% (<i>p</i> < 0.007). Conclusions: Our study, through univariate analyses, found a relationship between a TCaScore > 100, lower 1-year eGFR, and decreased renal function in 5 years. However, a higher-than-expected vascular calcification should not be an excluding factor in donors, although they may require closer monitoring during follow-up. |
| first_indexed | 2024-03-11T04:14:13Z |
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| id | doaj.art-771aaef35e49455cae300bfd9c694e50 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T04:14:13Z |
| publishDate | 2023-05-01 |
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| spelling | doaj.art-771aaef35e49455cae300bfd9c694e502023-11-17T23:13:54ZengMDPI AGJournal of Clinical Medicine2077-03832023-05-01129333910.3390/jcm12093339Association of the Calcification Score of the Abdominal Aorta, Common Iliac, and Renal Arteries with Outcomes in Living Kidney DonorsLuís Costa Ribeiro0Manuela Almeida1Jorge Malheiro2Filipa Silva3Diogo Nunes-Carneiro4La Salete Martins5Sofia Pedroso6Miguel Silva-Ramos7School of Medicine and Biomedical Sciences, University of Porto, 4050-313 Porto, PortugalNephrology and Kidney Transplantation Department, Centro Hospitalar e Universitário do Porto, 4050-366 Porto, PortugalNephrology and Kidney Transplantation Department, Centro Hospitalar e Universitário do Porto, 4050-366 Porto, PortugalNephrology and Kidney Transplantation Department, Centro Hospitalar e Universitário do Porto, 4050-366 Porto, PortugalUrology Department, Centro Hospitalar e Universitário do Porto, 4050-366 Porto, PortugalNephrology and Kidney Transplantation Department, Centro Hospitalar e Universitário do Porto, 4050-366 Porto, PortugalNephrology and Kidney Transplantation Department, Centro Hospitalar e Universitário do Porto, 4050-366 Porto, PortugalUrology Department, Centro Hospitalar e Universitário do Porto, 4050-366 Porto, PortugalBackground: Vascular calcification is an ever-more-common finding in protocoled pre-transplant imaging in living kidney donors. We intended to explore whether a connection could be found between the Agatston calcification score, prior to kidney donation, and post-donation renal function. Methods: This is a retrospective analysis of 156 living kidney donors who underwent living donor nephrectomy between January 2010 and December 2016. We quantified the total calcification score (TCaScore) by calculating the Agatston score for each vessel, abdominal aorta, common iliac, and renal arteries. Donors were placed into two different groups based on their TCaScore: <100 TCaScore group and ≥100 TCaScore group. The relationship between TCaScore, 1-year eGFR, proteinuria, and risk of 1 measurement of decreased renal function (eGFR < 60 mL/min/1.73 m<sup>2</sup>) over 5 years of follow-up was investigated. Results: The ≥100 TCaScore group consisted of 29 (19%) donors, with a median (interquartile range) calcification score of 164 (117–358). This group was significantly older, 56.7 ± 6.9 vs. 45.5 ± 10.6 (<i>p</i> < 0.001), had a higher average BMI (<i>p</i> < 0.019), and had a lower preoperative eGFR (<i>p</i> < 0.014). The 1-year eGFR was similarly diminished, 69.9 ± 15.7 vs. 76.3 ± 15.5 (<i>p</i> < 0.048), while also having an increased risk of decreased renal function during the follow-up, 22% vs. 48% (<i>p</i> < 0.007). Conclusions: Our study, through univariate analyses, found a relationship between a TCaScore > 100, lower 1-year eGFR, and decreased renal function in 5 years. However, a higher-than-expected vascular calcification should not be an excluding factor in donors, although they may require closer monitoring during follow-up.https://www.mdpi.com/2077-0383/12/9/3339kidney transplantationvascular calcificationAgatston scoredonor outcomesexpanded criteria donors |
| spellingShingle | Luís Costa Ribeiro Manuela Almeida Jorge Malheiro Filipa Silva Diogo Nunes-Carneiro La Salete Martins Sofia Pedroso Miguel Silva-Ramos Association of the Calcification Score of the Abdominal Aorta, Common Iliac, and Renal Arteries with Outcomes in Living Kidney Donors Journal of Clinical Medicine kidney transplantation vascular calcification Agatston score donor outcomes expanded criteria donors |
| title | Association of the Calcification Score of the Abdominal Aorta, Common Iliac, and Renal Arteries with Outcomes in Living Kidney Donors |
| title_full | Association of the Calcification Score of the Abdominal Aorta, Common Iliac, and Renal Arteries with Outcomes in Living Kidney Donors |
| title_fullStr | Association of the Calcification Score of the Abdominal Aorta, Common Iliac, and Renal Arteries with Outcomes in Living Kidney Donors |
| title_full_unstemmed | Association of the Calcification Score of the Abdominal Aorta, Common Iliac, and Renal Arteries with Outcomes in Living Kidney Donors |
| title_short | Association of the Calcification Score of the Abdominal Aorta, Common Iliac, and Renal Arteries with Outcomes in Living Kidney Donors |
| title_sort | association of the calcification score of the abdominal aorta common iliac and renal arteries with outcomes in living kidney donors |
| topic | kidney transplantation vascular calcification Agatston score donor outcomes expanded criteria donors |
| url | https://www.mdpi.com/2077-0383/12/9/3339 |
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