Clerodane Diterpenoids from <i>Callicarpa hypoleucophylla</i> and Their Anti-Inflammatory Activity
Plants of the genus <i>Callicarpa</i> are known to possess several medicinal effects. The constituents of the Taiwan endemic plant <i>Callicarpa hypoleucophylla</i> have never been studied. Therefore, <i>C. hypoleucophylla</i> was selected for our phytochemical in...
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MDPI AG
2020-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/10/2288 |
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| author | Yu-Chi Lin Jue-Jun Lin Shu-Rong Chen Tsong-Long Hwang Shu-Yen Fang Michal Korinek Ching-Yeu Chen Yun-Sheng Lin Tung-Ying Wu Ming-Hong Yen Chih-Hsin Wang Yuan-Bin Cheng |
| author_facet | Yu-Chi Lin Jue-Jun Lin Shu-Rong Chen Tsong-Long Hwang Shu-Yen Fang Michal Korinek Ching-Yeu Chen Yun-Sheng Lin Tung-Ying Wu Ming-Hong Yen Chih-Hsin Wang Yuan-Bin Cheng |
| author_sort | Yu-Chi Lin |
| collection | DOAJ |
| description | Plants of the genus <i>Callicarpa</i> are known to possess several medicinal effects. The constituents of the Taiwan endemic plant <i>Callicarpa hypoleucophylla</i> have never been studied. Therefore, <i>C. hypoleucophylla</i> was selected for our phytochemical investigation. Two new clerodane-type diterpenoids, named callihypolins A (<b>1</b>) and B (<b>2</b>), along with seven known compounds were isolated from the leaves and twigs of the Lamiaceae plant <i>C. hypoleucophylla</i> and then characterized. The structures of compounds <b>1</b> and <b>2</b> were elucidated by spectroscopic data analysis, specifically, two-dimension nuclear magnetic resonance (NMR). The anti-inflammatory activity of compounds <b>1</b>–<b>9</b> based on the suppression of superoxide anion generation and elastase release was evaluated. Among the isolates, compounds <b>2</b>–<b>4</b> showed anti-inflammatory activity (9.52−32.48% inhibition at the concentration 10 μm) by suppressing superoxide anion generation and elastase release. Our findings not only expand the description of the structural diversity of the compounds present in plants of the genus <i>Callicarpa</i> but also highlight the possibility of developing anti-inflammatory agents from <i>Callicarpa</i> endemic species. |
| first_indexed | 2024-03-10T19:52:38Z |
| format | Article |
| id | doaj.art-771aee9e5a464a5cbdd460f20d44ca9c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T19:52:38Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-771aee9e5a464a5cbdd460f20d44ca9c2023-11-20T00:17:24ZengMDPI AGMolecules1420-30492020-05-012510228810.3390/molecules25102288Clerodane Diterpenoids from <i>Callicarpa hypoleucophylla</i> and Their Anti-Inflammatory ActivityYu-Chi Lin0Jue-Jun Lin1Shu-Rong Chen2Tsong-Long Hwang3Shu-Yen Fang4Michal Korinek5Ching-Yeu Chen6Yun-Sheng Lin7Tung-Ying Wu8Ming-Hong Yen9Chih-Hsin Wang10Yuan-Bin Cheng11Graduate Institute of Natural Products, Center for Natural Product Research and Development, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, TaiwanGraduate Institute of Natural Products, Center for Natural Product Research and Development, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, TaiwanGraduate Institute of Natural Products, Center for Natural Product Research and Development, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, TaiwanGraduate Institute of Natural Products, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, TaiwanGraduate Institute of Natural Products, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, TaiwanGraduate Institute of Natural Products, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, TaiwanDepartment of Physical Therapy, Tzu-Hui Institute of Technology, Pingtung 92641, TaiwanDepartment of Biological Science and Technology, Meiho University, Pingtung 912009, TaiwanDepartment of Biological Science and Technology, Meiho University, Pingtung 912009, TaiwanSchool of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDivision of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 81342, TaiwanGraduate Institute of Natural Products, Center for Natural Product Research and Development, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, TaiwanPlants of the genus <i>Callicarpa</i> are known to possess several medicinal effects. The constituents of the Taiwan endemic plant <i>Callicarpa hypoleucophylla</i> have never been studied. Therefore, <i>C. hypoleucophylla</i> was selected for our phytochemical investigation. Two new clerodane-type diterpenoids, named callihypolins A (<b>1</b>) and B (<b>2</b>), along with seven known compounds were isolated from the leaves and twigs of the Lamiaceae plant <i>C. hypoleucophylla</i> and then characterized. The structures of compounds <b>1</b> and <b>2</b> were elucidated by spectroscopic data analysis, specifically, two-dimension nuclear magnetic resonance (NMR). The anti-inflammatory activity of compounds <b>1</b>–<b>9</b> based on the suppression of superoxide anion generation and elastase release was evaluated. Among the isolates, compounds <b>2</b>–<b>4</b> showed anti-inflammatory activity (9.52−32.48% inhibition at the concentration 10 μm) by suppressing superoxide anion generation and elastase release. Our findings not only expand the description of the structural diversity of the compounds present in plants of the genus <i>Callicarpa</i> but also highlight the possibility of developing anti-inflammatory agents from <i>Callicarpa</i> endemic species.https://www.mdpi.com/1420-3049/25/10/2288<i>Callicarpa hypoleucophylla</i>clerodane diterpenoidanti-inflammatory activity |
| spellingShingle | Yu-Chi Lin Jue-Jun Lin Shu-Rong Chen Tsong-Long Hwang Shu-Yen Fang Michal Korinek Ching-Yeu Chen Yun-Sheng Lin Tung-Ying Wu Ming-Hong Yen Chih-Hsin Wang Yuan-Bin Cheng Clerodane Diterpenoids from <i>Callicarpa hypoleucophylla</i> and Their Anti-Inflammatory Activity Molecules <i>Callicarpa hypoleucophylla</i> clerodane diterpenoid anti-inflammatory activity |
| title | Clerodane Diterpenoids from <i>Callicarpa hypoleucophylla</i> and Their Anti-Inflammatory Activity |
| title_full | Clerodane Diterpenoids from <i>Callicarpa hypoleucophylla</i> and Their Anti-Inflammatory Activity |
| title_fullStr | Clerodane Diterpenoids from <i>Callicarpa hypoleucophylla</i> and Their Anti-Inflammatory Activity |
| title_full_unstemmed | Clerodane Diterpenoids from <i>Callicarpa hypoleucophylla</i> and Their Anti-Inflammatory Activity |
| title_short | Clerodane Diterpenoids from <i>Callicarpa hypoleucophylla</i> and Their Anti-Inflammatory Activity |
| title_sort | clerodane diterpenoids from i callicarpa hypoleucophylla i and their anti inflammatory activity |
| topic | <i>Callicarpa hypoleucophylla</i> clerodane diterpenoid anti-inflammatory activity |
| url | https://www.mdpi.com/1420-3049/25/10/2288 |
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