Induction maintenance concept for HAART as initial treatment in HIV infected infants
<p>Abstract</p> <p>Background</p> <p>Early initiated antiretroviral therapy (ART) in HIV infected infants leads to improved long-term viral suppression and survival. Guidelines recommend initiating therapy with a triple ART consisting of two nucleoside reverse transcrip...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-06-01
|
| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | http://www.eurjmedres.com/content/16/6/243 |
| _version_ | 1818806196521402368 |
|---|---|
| author | Ghosh S Neubert J Niehues T Adams O Morali-Karzei N Borkhardt A Laws HJ |
| author_facet | Ghosh S Neubert J Niehues T Adams O Morali-Karzei N Borkhardt A Laws HJ |
| author_sort | Ghosh S |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Early initiated antiretroviral therapy (ART) in HIV infected infants leads to improved long-term viral suppression and survival. Guidelines recommend initiating therapy with a triple ART consisting of two nucleoside reverse transcriptase inhibitors (NRTIs) and either one additional non-nucleoside reverse transcriptase inhibitor (NNRTI) or a protease inhibitor (PI). Compared to older children and adults, viral relapse is seen more frequently in infants receiving triple ART. We now address the possibility of a more potent ART with a quadruple induction and triple maintenance therapy.</p> <p>Methods</p> <p>We examine the longitudinal course in four HIV infected infants, who were referred from other centers and could not be recruited to multicentre trials. We introduced ART initially consisting of two NRTIs, one NNRTI and one PI and later discontinued the PI at the age of 12 months maintaining a triple regime consisting of two NRTIs and one NNRTI.</p> <p>Results</p> <p>Provided that therapy adherence was maintained we observed an effective sustained decline of viral load and significant CD4 cell reconstitution even after switching to a triple regime. No drug associated toxicity was seen.</p> <p>Conclusion</p> <p>We suggest that a four drug therapy might be a possible initial therapy option in HIV infected infants, at least in those with a high viral load, followed by a maintenance triple regime after 12 months of therapy.</p> |
| first_indexed | 2024-12-18T19:05:56Z |
| format | Article |
| id | doaj.art-771b0961e573466299086bc5e6cea9f1 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-12-18T19:05:56Z |
| publishDate | 2011-06-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-771b0961e573466299086bc5e6cea9f12022-12-21T20:56:24ZengBMCEuropean Journal of Medical Research2047-783X2011-06-0116624310.1186/2047-783X-16-6-243Induction maintenance concept for HAART as initial treatment in HIV infected infantsGhosh SNeubert JNiehues TAdams OMorali-Karzei NBorkhardt ALaws HJ<p>Abstract</p> <p>Background</p> <p>Early initiated antiretroviral therapy (ART) in HIV infected infants leads to improved long-term viral suppression and survival. Guidelines recommend initiating therapy with a triple ART consisting of two nucleoside reverse transcriptase inhibitors (NRTIs) and either one additional non-nucleoside reverse transcriptase inhibitor (NNRTI) or a protease inhibitor (PI). Compared to older children and adults, viral relapse is seen more frequently in infants receiving triple ART. We now address the possibility of a more potent ART with a quadruple induction and triple maintenance therapy.</p> <p>Methods</p> <p>We examine the longitudinal course in four HIV infected infants, who were referred from other centers and could not be recruited to multicentre trials. We introduced ART initially consisting of two NRTIs, one NNRTI and one PI and later discontinued the PI at the age of 12 months maintaining a triple regime consisting of two NRTIs and one NNRTI.</p> <p>Results</p> <p>Provided that therapy adherence was maintained we observed an effective sustained decline of viral load and significant CD4 cell reconstitution even after switching to a triple regime. No drug associated toxicity was seen.</p> <p>Conclusion</p> <p>We suggest that a four drug therapy might be a possible initial therapy option in HIV infected infants, at least in those with a high viral load, followed by a maintenance triple regime after 12 months of therapy.</p>http://www.eurjmedres.com/content/16/6/243HIVHAARTanti HIV agentsinfantsviral load |
| spellingShingle | Ghosh S Neubert J Niehues T Adams O Morali-Karzei N Borkhardt A Laws HJ Induction maintenance concept for HAART as initial treatment in HIV infected infants European Journal of Medical Research HIV HAART anti HIV agents infants viral load |
| title | Induction maintenance concept for HAART as initial treatment in HIV infected infants |
| title_full | Induction maintenance concept for HAART as initial treatment in HIV infected infants |
| title_fullStr | Induction maintenance concept for HAART as initial treatment in HIV infected infants |
| title_full_unstemmed | Induction maintenance concept for HAART as initial treatment in HIV infected infants |
| title_short | Induction maintenance concept for HAART as initial treatment in HIV infected infants |
| title_sort | induction maintenance concept for haart as initial treatment in hiv infected infants |
| topic | HIV HAART anti HIV agents infants viral load |
| url | http://www.eurjmedres.com/content/16/6/243 |
| work_keys_str_mv | AT ghoshs inductionmaintenanceconceptforhaartasinitialtreatmentinhivinfectedinfants AT neubertj inductionmaintenanceconceptforhaartasinitialtreatmentinhivinfectedinfants AT niehuest inductionmaintenanceconceptforhaartasinitialtreatmentinhivinfectedinfants AT adamso inductionmaintenanceconceptforhaartasinitialtreatmentinhivinfectedinfants AT moralikarzein inductionmaintenanceconceptforhaartasinitialtreatmentinhivinfectedinfants AT borkhardta inductionmaintenanceconceptforhaartasinitialtreatmentinhivinfectedinfants AT lawshj inductionmaintenanceconceptforhaartasinitialtreatmentinhivinfectedinfants |