Alcohol Consumption during Pregnancy: Analysis of Two Direct Metabolites of Ethanol in Meconium
Alcohol consumption in young women is a widespread habit that may continue during pregnancy and induce alterations in the fetus. We aimed to characterize prevalence of alcohol consumption in parturient women and to assess fetal ethanol exposure in their newborns by analyzing two direct metabolites o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/17/3/417 |
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| author | Arantza Sanvisens Neus Robert José María Hernández Paola Zuluaga Magí Farré Wifredo Coroleu Montserrat Serra Jordi Tor Robert Muga |
| author_facet | Arantza Sanvisens Neus Robert José María Hernández Paola Zuluaga Magí Farré Wifredo Coroleu Montserrat Serra Jordi Tor Robert Muga |
| author_sort | Arantza Sanvisens |
| collection | DOAJ |
| description | Alcohol consumption in young women is a widespread habit that may continue during pregnancy and induce alterations in the fetus. We aimed to characterize prevalence of alcohol consumption in parturient women and to assess fetal ethanol exposure in their newborns by analyzing two direct metabolites of ethanol in meconium. This is a cross-sectional study performed in September 2011 and March 2012 in a series of women admitted to an obstetric unit following childbirth. During admission, socio-demographic and substance use (alcohol, tobacco, cannabis, cocaine, and opiates) during pregnancy were assessed using a structured questionnaire and clinical charts. We also recorded the characteristics of pregnancy, childbirth, and neonates. The meconium analysis was performed by liquid chromatography—tandem mass spectrometry (LC-MS/MS) to detect the presence of ethyl glucuronide (EtG) and ethyl sulfate (EtS). Fifty-one parturient and 52 neonates were included and 48 meconium samples were suitable for EtG and EtS detection. The median age of women was 30 years (interquartile range (IQR): 26–34 years); EtG was present in all meconium samples and median concentration of EtG was 67.9 ng/g (IQR: 36.0–110.6 ng/g). With respect to EtS, it was undetectable (<0.01 ng/g) in the majority of samples (79.1%). Only three (6%) women reported alcohol consumption during pregnancy in face-to-face interviews. However, prevalence of fetal exposure to alcohol through the detection of EtG and EtS was 4.2% and 16.7%, respectively. Prevention of alcohol consumption during pregnancy and the detection of substance use with markers of fetal exposure are essential components of maternal and child health. |
| first_indexed | 2024-04-11T23:42:08Z |
| format | Article |
| id | doaj.art-771b8feb69264f4b860d02ef72a01b55 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-11T23:42:08Z |
| publishDate | 2016-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-771b8feb69264f4b860d02ef72a01b552022-12-22T03:56:45ZengMDPI AGInternational Journal of Molecular Sciences1422-00672016-03-0117341710.3390/ijms17030417ijms17030417Alcohol Consumption during Pregnancy: Analysis of Two Direct Metabolites of Ethanol in MeconiumArantza Sanvisens0Neus Robert1José María Hernández2Paola Zuluaga3Magí Farré4Wifredo Coroleu5Montserrat Serra6Jordi Tor7Robert Muga8Departments of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, SpainEmergency Medicine, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, SpainProteomic and Metabolomic Unit, Fundació Institut d’Investigació Germans Trias i Pujol, 08916 Badalona, SpainDepartments of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, SpainClinical Pharmacology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, SpainPaediatrics, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, SpainObstetrics and Gyneacology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, SpainDepartments of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, SpainDepartments of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, SpainAlcohol consumption in young women is a widespread habit that may continue during pregnancy and induce alterations in the fetus. We aimed to characterize prevalence of alcohol consumption in parturient women and to assess fetal ethanol exposure in their newborns by analyzing two direct metabolites of ethanol in meconium. This is a cross-sectional study performed in September 2011 and March 2012 in a series of women admitted to an obstetric unit following childbirth. During admission, socio-demographic and substance use (alcohol, tobacco, cannabis, cocaine, and opiates) during pregnancy were assessed using a structured questionnaire and clinical charts. We also recorded the characteristics of pregnancy, childbirth, and neonates. The meconium analysis was performed by liquid chromatography—tandem mass spectrometry (LC-MS/MS) to detect the presence of ethyl glucuronide (EtG) and ethyl sulfate (EtS). Fifty-one parturient and 52 neonates were included and 48 meconium samples were suitable for EtG and EtS detection. The median age of women was 30 years (interquartile range (IQR): 26–34 years); EtG was present in all meconium samples and median concentration of EtG was 67.9 ng/g (IQR: 36.0–110.6 ng/g). With respect to EtS, it was undetectable (<0.01 ng/g) in the majority of samples (79.1%). Only three (6%) women reported alcohol consumption during pregnancy in face-to-face interviews. However, prevalence of fetal exposure to alcohol through the detection of EtG and EtS was 4.2% and 16.7%, respectively. Prevention of alcohol consumption during pregnancy and the detection of substance use with markers of fetal exposure are essential components of maternal and child health.http://www.mdpi.com/1422-0067/17/3/417fetal ethanol exposuremeconiumethyl glucuronideethyl sulfate |
| spellingShingle | Arantza Sanvisens Neus Robert José María Hernández Paola Zuluaga Magí Farré Wifredo Coroleu Montserrat Serra Jordi Tor Robert Muga Alcohol Consumption during Pregnancy: Analysis of Two Direct Metabolites of Ethanol in Meconium International Journal of Molecular Sciences fetal ethanol exposure meconium ethyl glucuronide ethyl sulfate |
| title | Alcohol Consumption during Pregnancy: Analysis of Two Direct Metabolites of Ethanol in Meconium |
| title_full | Alcohol Consumption during Pregnancy: Analysis of Two Direct Metabolites of Ethanol in Meconium |
| title_fullStr | Alcohol Consumption during Pregnancy: Analysis of Two Direct Metabolites of Ethanol in Meconium |
| title_full_unstemmed | Alcohol Consumption during Pregnancy: Analysis of Two Direct Metabolites of Ethanol in Meconium |
| title_short | Alcohol Consumption during Pregnancy: Analysis of Two Direct Metabolites of Ethanol in Meconium |
| title_sort | alcohol consumption during pregnancy analysis of two direct metabolites of ethanol in meconium |
| topic | fetal ethanol exposure meconium ethyl glucuronide ethyl sulfate |
| url | http://www.mdpi.com/1422-0067/17/3/417 |
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