TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis

TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis

Abstract Background Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has previously been demonstrated to play a pro-inflammatory role in allergic airways disease and COPD through the upregulation of the E3 ubiquitin ligase MID1 and the subsequent deactivation of protein phosphatase 2...

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Bibliographic Details
Main Authors: Adam M. Collison, Junyao Li, Ana Pereira de Siqueira, Xuejiao Lv, Hamish D. Toop, Jonathan C. Morris, Malcolm R. Starkey, Philip M. Hansbro, Jie Zhang, Joerg Mattes
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Pulmonary Medicine
Subjects:
TRAIL
MID1
PP2A
Fibrosis
E3 ubiquitin ligase
Online Access:http://link.springer.com/article/10.1186/s12890-019-0786-x

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