The Etiology and Pathophysiology Genesis of Benign Prostatic Hyperplasia and Prostate Cancer: A New Perspective
Background: The etiology of benign prostatic hyperplasia and prostate cancer are unknown, with ageing being the greatness risk factor. Methods: This new perspective evaluates the available interdisciplinary evidence regarding prostate ageing in terms of the cell biology of regulation and homeostasis...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Medicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2305-6320/8/6/30 |
| _version_ | 1797530532230201344 |
|---|---|
| author | Teow J. Phua |
| author_facet | Teow J. Phua |
| author_sort | Teow J. Phua |
| collection | DOAJ |
| description | Background: The etiology of benign prostatic hyperplasia and prostate cancer are unknown, with ageing being the greatness risk factor. Methods: This new perspective evaluates the available interdisciplinary evidence regarding prostate ageing in terms of the cell biology of regulation and homeostasis, which could explain the timeline of evolutionary cancer biology as degenerative, inflammatory and neoplasm progressions in these multifactorial and heterogeneous prostatic diseases. Results: This prostate ageing degeneration hypothesis encompasses the testosterone-vascular-inflamm-ageing triad, along with the cell biology regulation of amyloidosis and autophagy within an evolutionary tumorigenesis microenvironment. Conclusions: An understanding of these biological processes of prostate ageing can provide potential strategies for early prevention and could contribute to maintaining quality of life for the ageing individual along with substantial medical cost savings. |
| first_indexed | 2024-03-10T10:30:20Z |
| format | Article |
| id | doaj.art-771fdd1f6b3449dab3554b6259de6b77 |
| institution | Directory Open Access Journal |
| issn | 2305-6320 |
| language | English |
| last_indexed | 2024-03-10T10:30:20Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicines |
| spelling | doaj.art-771fdd1f6b3449dab3554b6259de6b772023-11-21T23:43:09ZengMDPI AGMedicines2305-63202021-06-01863010.3390/medicines8060030The Etiology and Pathophysiology Genesis of Benign Prostatic Hyperplasia and Prostate Cancer: A New PerspectiveTeow J. Phua0Molecular Medicine, NSW Health Pathology, John Hunter Hospital, Newcastle, NSW 2305, AustraliaBackground: The etiology of benign prostatic hyperplasia and prostate cancer are unknown, with ageing being the greatness risk factor. Methods: This new perspective evaluates the available interdisciplinary evidence regarding prostate ageing in terms of the cell biology of regulation and homeostasis, which could explain the timeline of evolutionary cancer biology as degenerative, inflammatory and neoplasm progressions in these multifactorial and heterogeneous prostatic diseases. Results: This prostate ageing degeneration hypothesis encompasses the testosterone-vascular-inflamm-ageing triad, along with the cell biology regulation of amyloidosis and autophagy within an evolutionary tumorigenesis microenvironment. Conclusions: An understanding of these biological processes of prostate ageing can provide potential strategies for early prevention and could contribute to maintaining quality of life for the ageing individual along with substantial medical cost savings.https://www.mdpi.com/2305-6320/8/6/30benign prostatic hyperplasiaprostate cancertestosterone agingvascular aginginflamm-agingamyloidosis |
| spellingShingle | Teow J. Phua The Etiology and Pathophysiology Genesis of Benign Prostatic Hyperplasia and Prostate Cancer: A New Perspective Medicines benign prostatic hyperplasia prostate cancer testosterone aging vascular aging inflamm-aging amyloidosis |
| title | The Etiology and Pathophysiology Genesis of Benign Prostatic Hyperplasia and Prostate Cancer: A New Perspective |
| title_full | The Etiology and Pathophysiology Genesis of Benign Prostatic Hyperplasia and Prostate Cancer: A New Perspective |
| title_fullStr | The Etiology and Pathophysiology Genesis of Benign Prostatic Hyperplasia and Prostate Cancer: A New Perspective |
| title_full_unstemmed | The Etiology and Pathophysiology Genesis of Benign Prostatic Hyperplasia and Prostate Cancer: A New Perspective |
| title_short | The Etiology and Pathophysiology Genesis of Benign Prostatic Hyperplasia and Prostate Cancer: A New Perspective |
| title_sort | etiology and pathophysiology genesis of benign prostatic hyperplasia and prostate cancer a new perspective |
| topic | benign prostatic hyperplasia prostate cancer testosterone aging vascular aging inflamm-aging amyloidosis |
| url | https://www.mdpi.com/2305-6320/8/6/30 |
| work_keys_str_mv | AT teowjphua theetiologyandpathophysiologygenesisofbenignprostatichyperplasiaandprostatecanceranewperspective AT teowjphua etiologyandpathophysiologygenesisofbenignprostatichyperplasiaandprostatecanceranewperspective |