Aromatase Inhibitors as a Promising Direction for the Search for New Anticancer Drugs
Aromatase is an enzyme that plays a crucial role in the biosynthesis of estrogens, which are hormones that contribute to the growth of certain types of breast cancer. In particular, aromatase catalyzes the conversion of androgens (male hormones) into estrogens (female hormones) in various tissues, i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/2/346 |
| _version_ | 1797339547942518784 |
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| author | Sara Janowska Serhii Holota Roman Lesyk Monika Wujec |
| author_facet | Sara Janowska Serhii Holota Roman Lesyk Monika Wujec |
| author_sort | Sara Janowska |
| collection | DOAJ |
| description | Aromatase is an enzyme that plays a crucial role in the biosynthesis of estrogens, which are hormones that contribute to the growth of certain types of breast cancer. In particular, aromatase catalyzes the conversion of androgens (male hormones) into estrogens (female hormones) in various tissues, including the adrenal glands, ovaries, and adipose tissue. Given the role of estrogen in promoting the growth of hormone-receptor-positive breast cancers, aromatase has become an important molecular target for the development of anticancer agents. Aromatase inhibitors can be classified into two main groups based on their chemical structure: steroidal and non-steroidal inhibitors. This work presents a review of the literature from the last ten years regarding the search for new aromatase inhibitors. We present the directions of search, taking into account the impact of structure modifications on anticancer activity. |
| first_indexed | 2024-03-08T09:49:46Z |
| format | Article |
| id | doaj.art-7723771bfe3a416da326cb5751e78555 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-08T09:49:46Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-7723771bfe3a416da326cb5751e785552024-01-29T14:07:44ZengMDPI AGMolecules1420-30492024-01-0129234610.3390/molecules29020346Aromatase Inhibitors as a Promising Direction for the Search for New Anticancer DrugsSara Janowska0Serhii Holota1Roman Lesyk2Monika Wujec3Department of Pathobiochemistry and Interdisciplinary Applications of Ion Chromatography, Biomedical Sciences, Medical University of Lublin, 1 Chodzki Street, 20-093 Lublin, PolandDepartment of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, UkraineDepartment of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, UkraineDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4A Chodzki Street, 20-093 Lublin, PolandAromatase is an enzyme that plays a crucial role in the biosynthesis of estrogens, which are hormones that contribute to the growth of certain types of breast cancer. In particular, aromatase catalyzes the conversion of androgens (male hormones) into estrogens (female hormones) in various tissues, including the adrenal glands, ovaries, and adipose tissue. Given the role of estrogen in promoting the growth of hormone-receptor-positive breast cancers, aromatase has become an important molecular target for the development of anticancer agents. Aromatase inhibitors can be classified into two main groups based on their chemical structure: steroidal and non-steroidal inhibitors. This work presents a review of the literature from the last ten years regarding the search for new aromatase inhibitors. We present the directions of search, taking into account the impact of structure modifications on anticancer activity.https://www.mdpi.com/1420-3049/29/2/346aromatase inhibitorssteroidal and non-steroidal compoundsanticancer activity |
| spellingShingle | Sara Janowska Serhii Holota Roman Lesyk Monika Wujec Aromatase Inhibitors as a Promising Direction for the Search for New Anticancer Drugs Molecules aromatase inhibitors steroidal and non-steroidal compounds anticancer activity |
| title | Aromatase Inhibitors as a Promising Direction for the Search for New Anticancer Drugs |
| title_full | Aromatase Inhibitors as a Promising Direction for the Search for New Anticancer Drugs |
| title_fullStr | Aromatase Inhibitors as a Promising Direction for the Search for New Anticancer Drugs |
| title_full_unstemmed | Aromatase Inhibitors as a Promising Direction for the Search for New Anticancer Drugs |
| title_short | Aromatase Inhibitors as a Promising Direction for the Search for New Anticancer Drugs |
| title_sort | aromatase inhibitors as a promising direction for the search for new anticancer drugs |
| topic | aromatase inhibitors steroidal and non-steroidal compounds anticancer activity |
| url | https://www.mdpi.com/1420-3049/29/2/346 |
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