Genetic and functional modularity of Hox activities in the specification of limb-innervating motor neurons.

Genetic and functional modularity of Hox activities in the specification of limb-innervating motor neurons.

A critical step in the assembly of the neural circuits that control tetrapod locomotion is the specification of the lateral motor column (LMC), a diverse motor neuron population targeting limb musculature. Hox6 paralog group genes have been implicated as key determinants of LMC fate at forelimb leve...

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Bibliographic Details
Main Authors: Julie Lacombe, Olivia Hanley, Heekyung Jung, Polyxeni Philippidou, Gulsen Surmeli, Jonathan Grinstein, Jeremy S Dasen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3554521?pdf=render

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