Role of phosphatidylinositol 4,5-bisphosphate in regulating EHD2 plasma membrane localization.

Role of phosphatidylinositol 4,5-bisphosphate in regulating EHD2 plasma membrane localization.

The four mammalian C-terminal Eps15 homology domain-containing proteins (EHD1-EHD4) play pivotal roles in endocytic membrane trafficking. While EHD1, EHD3 and EHD4 associate with intracellular tubular/vesicular membranes, EHD2 localizes to the inner leaflet of the plasma membrane. Currently, little...

Full description

Bibliographic Details
Main Authors:	Laura C Simone, Steve Caplan, Naava Naslavsky
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3769341?pdf=render

Similar Items

Role of the EHD2 unstructured loop in dimerization, protein binding and subcellular localization.
by: Kriti Bahl, et al.
Published: (2015-01-01)

Eps15 Homology Domain Protein 4 (EHD4) is required for Eps15 Homology Domain Protein 1 (EHD1)-mediated endosomal recruitment and fission.
by: Tyler Jones, et al.
Published: (2020-01-01)

Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics
by: Kaori Kanemaru, et al.
Published: (2022-05-01)

Structure and Lateral Organization of Phosphatidylinositol 4,5-bisphosphate
by: Luís Borges-Araújo, et al.
Published: (2020-08-01)

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis
by: Alexander M Walter, et al.
Published: (2017-10-01)

Absence of clustering of phosphatidylinositol-(4,5)-bisphosphate in fluid phosphatidylcholine
by: Faébio Fernandes, et al.
Published: (2006-07-01)

Acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains
by: Luís Borges-Araújo, et al.
Published: (2021-11-01)

Effect of hormone-induced plasma membrane phosphatidylinositol 4,5-bisphosphate depletion on receptor endocytosis suggests the importance of local regulation in phosphoinositide signaling
by: Dániel J. Tóth, et al.
Published: (2024-01-01)

Neomycin Interferes with Phosphatidylinositol-4,5-Bisphosphate at the Yeast Plasma Membrane and Activates the Cell Wall Integrity Pathway
by: Elena Jiménez-Gutiérrez, et al.
Published: (2022-09-01)

Membrane Binding and Subcellular Localization of Retroviral Gag Proteins Are Differentially Regulated by MA Interactions with Phosphatidylinositol-(4,5)-Bisphosphate and RNA
by: Jingga Inlora, et al.
Published: (2014-12-01)

Phosphatidylinositol (4,5) bisphosphate controls T cell activation by regulating T cell rigidity and organization.
by: Yi Sun, et al.
Published: (2011-01-01)

Optogenetic dephosphorylation of phosphatidylinositol 4,5 bisphosphate in Xenopus laevis oocytes
by: Kirin D. Gada, et al.
Published: (2023-03-01)

Fixation-induced cell blebbing on spread cells inversely correlates with phosphatidylinositol 4,5-bisphosphate level in the plasma membrane
by: Siyuan Zhao, et al.
Published: (2014-01-01)

GRAF1 forms a complex with MICAL-L1 and EHD1 to cooperate in tubular recycling endosome vesiculation
by: Bishuang eCai, et al.
Published: (2014-05-01)

Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment.
by: Honigmann, A, et al.
Published: (2013)

Simulation-based prediction of phosphatidylinositol 4,5-bisphosphate binding to an ion channel.
by: Schmidt, MR, et al.
Published: (2013)

Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment
by: Honigmann, A, et al.
Published: (2013)

Phosphatidylinositol 4,5-Bisphosphate Mediates the Co-Distribution of Influenza A Hemagglutinin and Matrix Protein M1 at the Plasma Membrane
by: Prakash Raut, et al.
Published: (2022-11-01)

Receptor-mediated internalization promotes increased endosome size and number in a RAB4- and RAB5-dependent manner
by: Naava Naslavsky, et al.
Published: (2023-09-01)

A genetically encoded tool kit for manipulating and monitoring membrane phosphatidylinositol 4,5-bisphosphate in intact cells.
by: Fabian Hertel, et al.
Published: (2011-01-01)

A long QT mutation substitutes cholesterol for phosphatidylinositol-4,5-bisphosphate in KCNQ1 channel regulation.
by: Fabien C Coyan, et al.
Published: (2014-01-01)

Ca2+-dependent release of synaptotagmin-1 from the SNARE complex on phosphatidylinositol 4,5-bisphosphate-containing membranes
by: Rashmi Voleti, et al.
Published: (2020-08-01)

Structural characterization of the interaction between a Pleckstrin homology domain and phosphatidylinositol 4,5-bisphosphate
by: Harlan, John E., et al.
Published: (2012)

The Role of Class IA Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunits in Glioblastoma
by: Kevin J. Pridham, et al.
Published: (2017-12-01)

Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome
by: Cho, Nam-Joon, et al.
Published: (2016)

Phosphatidylinositol-4,5-bisphosphate enhances anionic lipid demixing by the C2 domain of PKCα.
by: Antonio L Egea-Jiménez, et al.
Published: (2014-01-01)

Phosphatidylinositol 4,5-bisphosphate (PIP2) facilitates norepinephrine transporter dimerization and modulates substrate efflux
by: Dino Luethi, et al.
Published: (2022-11-01)

Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking.
by: Alice A Royal, et al.
Published: (2017-01-01)

A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing
by: Libing Mu, et al.
Published: (2018-10-01)

Phosphatidylinositol-4,5-Bisphosphate Binding to Amphiphysin-II Modulates T-Tubule Remodeling: Implications for Heart Failure
by: Junlan Zhou, et al.
Published: (2021-12-01)

Increasing Phosphatidylinositol (4,5)-Bisphosphate Biosynthesis Affects Basal Signaling and Chloroplast Metabolism in Arabidopsis thaliana
by: Yang Ju Im, et al.
Published: (2014-01-01)

Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels.
by: Rapedius, M, et al.
Published: (2005)

Limited Proteolysis-Coupled Mass Spectrometry Identifies Phosphatidylinositol 4,5-Bisphosphate Effectors in Human Nuclear Proteome
by: Martin Sztacho, et al.
Published: (2021-01-01)

Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate
by: Yang He, et al.
Published: (2019-03-01)

Identifying potential inhibitors of phosphatidylinositol 4,5-bisphosphate 3-kinase: Molecular dynamic insights into the interaction and inhibitory mechanism
by: Taj Mohammad, et al.
Published: (2024-06-01)

Identification of postsynaptic phosphatidylinositol-4,5-bisphosphate (PIP2) roles for synaptic plasticity using chemically induced dimerization
by: Su-Jeong Kim, et al.
Published: (2017-06-01)

The distribution of phosphatidylinositol 4,5-bisphosphate in acinar cells of rat pancreas revealed with the freeze-fracture replica labeling method.
by: Nami Ozato-Sakurai, et al.
Published: (2011-01-01)

Contrasting effects of phosphatidylinositol 4,5-bisphosphate (PIP2 ) on cloned TMEM16A and TMEM16B channels
by: Ta, C, et al.
Published: (2017)

Lipid Messenger Phosphatidylinositol-4,5-Bisphosphate Is Increased by Both PPARα Activators and Inhibitors: Relevance for Intestinal Cell Differentiation
by: Katerina Cizkova, et al.
Published: (2022-06-01)

Diverse Physiological Functions of FAB1 and Phosphatidylinositol 3,5-Bisphosphate in Plants
by: Tomoko Hirano, et al.
Published: (2019-03-01)