Relationship between myocardial energy expenditure and postoperative ejection fraction in patients with severe mitral regurgitation
Objective: This prospective study aimed to investigate the myocardial energy metabolism in severe mitral regurgitation (MR) and explore its effect on postoperative differentiation of ejection fraction (EF). Methods: A total of 85 patients with severe MR were prospectively enrolled from October 2018...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2020-10-01
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| Series: | Anatolian Journal of Cardiology |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-03835 |
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| author | Hicaz Zencirkiran Agus Gamze Babur Guler Mehmet Ali Astarcioglu Ahmet Guner Ismail Gurbak Oya Atamaner Anil Sahin Ahmet Yasar Cizgici Alev Kilicgedik |
| author_facet | Hicaz Zencirkiran Agus Gamze Babur Guler Mehmet Ali Astarcioglu Ahmet Guner Ismail Gurbak Oya Atamaner Anil Sahin Ahmet Yasar Cizgici Alev Kilicgedik |
| author_sort | Hicaz Zencirkiran Agus |
| collection | DOAJ |
| description | Objective: This prospective study aimed to investigate the myocardial energy metabolism in severe mitral regurgitation (MR) and explore its effect on postoperative differentiation of ejection fraction (EF).
Methods: A total of 85 patients with severe MR were prospectively enrolled from October 2018 to June 2019. During the study period, a total of 50 patients underwent mitral valve surgery and 49 patients were finally enrolled due to 1 missing data. Left ventricular function, circumferential end-systolic stress (cESS), and myocardial energy expenditure (MEE) were measured by transthoracic echocardiography preoperatively and 3 months after surgery. Patients were divided into 2 groups according to absolute difference of postoperative differentiation of EF.
Results: Nine patients underwent mitral valve repair and 40 underwent prosthetic valve replacement. Patients with reduced EF had higher MEE demonstrated with cESS and MEE. Negative correlation between preoperative EF and N-terminal pro-brain natriuretic peptide (NT-proBNP), cESS, MEEs, and MEEm and positive correlation between preoperative EF and effective regurgitant orifice area were found. Complications occurred in 12 patients during hospitalization. Basal NT-proBNP, left atrium (LA), and cESS were significantly higher in postoperatively decreased EF group. Taking into consideration the covariates of multiple logistic regression analysis, LA and cESS were found to be independent predictors of EF reduction postoperatively.
Conclusion: Higher LA and cESS are independent predictors of postoperative EF reduction. Preoperative high end-systolic stress could predict postoperative EF reduction and hence could be helpful for determining the timing of mitral valve surgery. Although MEE was higher in postoperatively decreased EF group, it did not reach statistical significance. |
| first_indexed | 2024-04-10T12:00:26Z |
| format | Article |
| id | doaj.art-7726135e53f34db884bd846d50fea5c8 |
| institution | Directory Open Access Journal |
| issn | 2149-2263 |
| language | English |
| last_indexed | 2024-04-10T12:00:26Z |
| publishDate | 2020-10-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Anatolian Journal of Cardiology |
| spelling | doaj.art-7726135e53f34db884bd846d50fea5c82023-02-15T16:16:38ZengKARE PublishingAnatolian Journal of Cardiology2149-22632020-10-0124425425910.14744/AnatolJCardiol.2020.03835AJC-03835Relationship between myocardial energy expenditure and postoperative ejection fraction in patients with severe mitral regurgitationHicaz Zencirkiran Agus0Gamze Babur Guler1Mehmet Ali Astarcioglu2Ahmet Guner3Ismail Gurbak4Oya Atamaner5Anil Sahin6Ahmet Yasar Cizgici7Alev Kilicgedik8Department of Cardiology, University of Health Sciences, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Training and Research Hospital; İstanbul-TurkeyDepartment of Cardiology, University of Health Sciences, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Training and Research Hospital; İstanbul-TurkeyDepartment of Cardiology, Dumlupınar University, Kütahya Evliya Çelebi Training and Research Hospital; Kütahya-TurkeyDepartment of Cardiology, University of Health Sciences, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Training and Research Hospital; İstanbul-TurkeyDepartment of Cardiology, University of Health Sciences, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Training and Research Hospital; İstanbul-TurkeyDepartment of Cardiology, University of Health Sciences, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Training and Research Hospital; İstanbul-TurkeyDepartment of Cardiology, University of Health Sciences, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Training and Research Hospital; İstanbul-TurkeyDepartment of Cardiology, University of Health Sciences, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Training and Research Hospital; İstanbul-TurkeyDepartment of Cardiology, University of Health Sciences, Kartal Koşuyolu Training and Research Hospital; İstanbul-TurkeyObjective: This prospective study aimed to investigate the myocardial energy metabolism in severe mitral regurgitation (MR) and explore its effect on postoperative differentiation of ejection fraction (EF). Methods: A total of 85 patients with severe MR were prospectively enrolled from October 2018 to June 2019. During the study period, a total of 50 patients underwent mitral valve surgery and 49 patients were finally enrolled due to 1 missing data. Left ventricular function, circumferential end-systolic stress (cESS), and myocardial energy expenditure (MEE) were measured by transthoracic echocardiography preoperatively and 3 months after surgery. Patients were divided into 2 groups according to absolute difference of postoperative differentiation of EF. Results: Nine patients underwent mitral valve repair and 40 underwent prosthetic valve replacement. Patients with reduced EF had higher MEE demonstrated with cESS and MEE. Negative correlation between preoperative EF and N-terminal pro-brain natriuretic peptide (NT-proBNP), cESS, MEEs, and MEEm and positive correlation between preoperative EF and effective regurgitant orifice area were found. Complications occurred in 12 patients during hospitalization. Basal NT-proBNP, left atrium (LA), and cESS were significantly higher in postoperatively decreased EF group. Taking into consideration the covariates of multiple logistic regression analysis, LA and cESS were found to be independent predictors of EF reduction postoperatively. Conclusion: Higher LA and cESS are independent predictors of postoperative EF reduction. Preoperative high end-systolic stress could predict postoperative EF reduction and hence could be helpful for determining the timing of mitral valve surgery. Although MEE was higher in postoperatively decreased EF group, it did not reach statistical significance.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-03835ejection fractionend-systolic stressmitral regurgitationmitral valve surgerymyocardial energy expenditure |
| spellingShingle | Hicaz Zencirkiran Agus Gamze Babur Guler Mehmet Ali Astarcioglu Ahmet Guner Ismail Gurbak Oya Atamaner Anil Sahin Ahmet Yasar Cizgici Alev Kilicgedik Relationship between myocardial energy expenditure and postoperative ejection fraction in patients with severe mitral regurgitation Anatolian Journal of Cardiology ejection fraction end-systolic stress mitral regurgitation mitral valve surgery myocardial energy expenditure |
| title | Relationship between myocardial energy expenditure and postoperative ejection fraction in patients with severe mitral regurgitation |
| title_full | Relationship between myocardial energy expenditure and postoperative ejection fraction in patients with severe mitral regurgitation |
| title_fullStr | Relationship between myocardial energy expenditure and postoperative ejection fraction in patients with severe mitral regurgitation |
| title_full_unstemmed | Relationship between myocardial energy expenditure and postoperative ejection fraction in patients with severe mitral regurgitation |
| title_short | Relationship between myocardial energy expenditure and postoperative ejection fraction in patients with severe mitral regurgitation |
| title_sort | relationship between myocardial energy expenditure and postoperative ejection fraction in patients with severe mitral regurgitation |
| topic | ejection fraction end-systolic stress mitral regurgitation mitral valve surgery myocardial energy expenditure |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-03835 |
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