Molecular mechanisms of cellular metabolic homeostasis in stem cells
Abstract Many tissues and organ systems have intrinsic regeneration capabilities that are largely driven and maintained by tissue-resident stem cell populations. In recent years, growing evidence has demonstrated that cellular metabolic homeostasis plays a central role in mediating stem cell fate, t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-12-01
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| Series: | International Journal of Oral Science |
| Online Access: | https://doi.org/10.1038/s41368-023-00262-z |
| _version_ | 1797415841508098048 |
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| author | Xiaoyu Li Ou Jiang Songlin Wang |
| author_facet | Xiaoyu Li Ou Jiang Songlin Wang |
| author_sort | Xiaoyu Li |
| collection | DOAJ |
| description | Abstract Many tissues and organ systems have intrinsic regeneration capabilities that are largely driven and maintained by tissue-resident stem cell populations. In recent years, growing evidence has demonstrated that cellular metabolic homeostasis plays a central role in mediating stem cell fate, tissue regeneration, and homeostasis. Thus, a thorough understanding of the mechanisms that regulate metabolic homeostasis in stem cells may contribute to our knowledge on how tissue homeostasis is maintained and provide novel insights for disease management. In this review, we summarize the known relationship between the regulation of metabolic homeostasis and molecular pathways in stem cells. We also discuss potential targets of metabolic homeostasis in disease therapy and describe the current limitations and future directions in the development of these novel therapeutic targets. |
| first_indexed | 2024-03-09T05:55:22Z |
| format | Article |
| id | doaj.art-7726744d01a243a99f7faa2c88b14c02 |
| institution | Directory Open Access Journal |
| issn | 2049-3169 |
| language | English |
| last_indexed | 2024-03-09T05:55:22Z |
| publishDate | 2023-12-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | International Journal of Oral Science |
| spelling | doaj.art-7726744d01a243a99f7faa2c88b14c022023-12-03T12:14:19ZengNature Publishing GroupInternational Journal of Oral Science2049-31692023-12-0115111310.1038/s41368-023-00262-zMolecular mechanisms of cellular metabolic homeostasis in stem cellsXiaoyu Li0Ou Jiang1Songlin Wang2Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical UniversitySalivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical UniversitySalivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical UniversityAbstract Many tissues and organ systems have intrinsic regeneration capabilities that are largely driven and maintained by tissue-resident stem cell populations. In recent years, growing evidence has demonstrated that cellular metabolic homeostasis plays a central role in mediating stem cell fate, tissue regeneration, and homeostasis. Thus, a thorough understanding of the mechanisms that regulate metabolic homeostasis in stem cells may contribute to our knowledge on how tissue homeostasis is maintained and provide novel insights for disease management. In this review, we summarize the known relationship between the regulation of metabolic homeostasis and molecular pathways in stem cells. We also discuss potential targets of metabolic homeostasis in disease therapy and describe the current limitations and future directions in the development of these novel therapeutic targets.https://doi.org/10.1038/s41368-023-00262-z |
| spellingShingle | Xiaoyu Li Ou Jiang Songlin Wang Molecular mechanisms of cellular metabolic homeostasis in stem cells International Journal of Oral Science |
| title | Molecular mechanisms of cellular metabolic homeostasis in stem cells |
| title_full | Molecular mechanisms of cellular metabolic homeostasis in stem cells |
| title_fullStr | Molecular mechanisms of cellular metabolic homeostasis in stem cells |
| title_full_unstemmed | Molecular mechanisms of cellular metabolic homeostasis in stem cells |
| title_short | Molecular mechanisms of cellular metabolic homeostasis in stem cells |
| title_sort | molecular mechanisms of cellular metabolic homeostasis in stem cells |
| url | https://doi.org/10.1038/s41368-023-00262-z |
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