Effects of Glucomannan Supplementation on Type II Diabetes Mellitus in Humans: A Meta-Analysis
The hypoglycemic and lipid-lowering effects of glucomannan are widely known, and it is a potential effective treatment for type II diabetes. In this study, we evaluated the effects of glucomannan supplementation on blood-lipid-related indicators, blood-glucose-related indicators, blood pressure (BP)...
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MDPI AG
2023-01-01
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Online Access: | https://www.mdpi.com/2072-6643/15/3/601 |
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author | Zhanzhi Zhang Yu Zhang Xiaomei Tao Yuying Wang Benqiang Rao Hanping Shi |
author_facet | Zhanzhi Zhang Yu Zhang Xiaomei Tao Yuying Wang Benqiang Rao Hanping Shi |
author_sort | Zhanzhi Zhang |
collection | DOAJ |
description | The hypoglycemic and lipid-lowering effects of glucomannan are widely known, and it is a potential effective treatment for type II diabetes. In this study, we evaluated the effects of glucomannan supplementation on blood-lipid-related indicators, blood-glucose-related indicators, blood pressure (BP), and body weight (BW) in patients suffering from type II diabetes. We searched databases including PubMed, Cochrane, the comprehensive biomedical research database (Embase), Web of Science, and China National Knowledge Infrastructure (CNKI) for literature on glucomannan and type II diabetes. Six randomized controlled trials (RCTs) were eligible (<i>n</i> = 440 participants) to be included in our analysis. Glucomannan not only reduced the total cholesterol (TC) (MD −0.38 [95% CI: −0.61, −0.15], <i>p</i> = 0.001) and low-density lipoprotein (LDL) levels (MD −0.35 [95% CI: −0.52, −0.17], <i>p</i> < 0.0001) compared with the control group, but also reduced the fasting blood glucose (FBG) (MD −1.08 [95% CI: −1.65, −0.50], <i>p</i> = 0.0002), 2 h postprandial blood glucose (P2hBG) (MD −1.92 [95% CI: −3.19, −0.65], <i>p</i> = 0.003), fasting insulin (FINS) (MD −1.59 [95% CI: −2.69, −0.50], <i>p</i> = 0.004), and serum fructosamine (SFRA) levels (SMD −1.19 [95% CI: −1.74, −0.64], <i>p</i> < 0.0001). Our analysis indicates that glucomannan is an effective nutritional intervention for type II diabetes. |
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spelling | doaj.art-77279a8080334a25a9e575ee952f7cd92023-11-16T17:39:13ZengMDPI AGNutrients2072-66432023-01-0115360110.3390/nu15030601Effects of Glucomannan Supplementation on Type II Diabetes Mellitus in Humans: A Meta-AnalysisZhanzhi Zhang0Yu Zhang1Xiaomei Tao2Yuying Wang3Benqiang Rao4Hanping Shi5Department of General Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, ChinaDepartment of VIP Medical Services, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, ChinaDepartment of General Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, ChinaDepartment of General Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, ChinaKey Laboratory of Cancer FSMP for State Market Regulation, Beijing 100038, ChinaThe hypoglycemic and lipid-lowering effects of glucomannan are widely known, and it is a potential effective treatment for type II diabetes. In this study, we evaluated the effects of glucomannan supplementation on blood-lipid-related indicators, blood-glucose-related indicators, blood pressure (BP), and body weight (BW) in patients suffering from type II diabetes. We searched databases including PubMed, Cochrane, the comprehensive biomedical research database (Embase), Web of Science, and China National Knowledge Infrastructure (CNKI) for literature on glucomannan and type II diabetes. Six randomized controlled trials (RCTs) were eligible (<i>n</i> = 440 participants) to be included in our analysis. Glucomannan not only reduced the total cholesterol (TC) (MD −0.38 [95% CI: −0.61, −0.15], <i>p</i> = 0.001) and low-density lipoprotein (LDL) levels (MD −0.35 [95% CI: −0.52, −0.17], <i>p</i> < 0.0001) compared with the control group, but also reduced the fasting blood glucose (FBG) (MD −1.08 [95% CI: −1.65, −0.50], <i>p</i> = 0.0002), 2 h postprandial blood glucose (P2hBG) (MD −1.92 [95% CI: −3.19, −0.65], <i>p</i> = 0.003), fasting insulin (FINS) (MD −1.59 [95% CI: −2.69, −0.50], <i>p</i> = 0.004), and serum fructosamine (SFRA) levels (SMD −1.19 [95% CI: −1.74, −0.64], <i>p</i> < 0.0001). Our analysis indicates that glucomannan is an effective nutritional intervention for type II diabetes.https://www.mdpi.com/2072-6643/15/3/601type II diabetes mellitusglucomannannutritional interventionmeta-analysisRCTs |
spellingShingle | Zhanzhi Zhang Yu Zhang Xiaomei Tao Yuying Wang Benqiang Rao Hanping Shi Effects of Glucomannan Supplementation on Type II Diabetes Mellitus in Humans: A Meta-Analysis Nutrients type II diabetes mellitus glucomannan nutritional intervention meta-analysis RCTs |
title | Effects of Glucomannan Supplementation on Type II Diabetes Mellitus in Humans: A Meta-Analysis |
title_full | Effects of Glucomannan Supplementation on Type II Diabetes Mellitus in Humans: A Meta-Analysis |
title_fullStr | Effects of Glucomannan Supplementation on Type II Diabetes Mellitus in Humans: A Meta-Analysis |
title_full_unstemmed | Effects of Glucomannan Supplementation on Type II Diabetes Mellitus in Humans: A Meta-Analysis |
title_short | Effects of Glucomannan Supplementation on Type II Diabetes Mellitus in Humans: A Meta-Analysis |
title_sort | effects of glucomannan supplementation on type ii diabetes mellitus in humans a meta analysis |
topic | type II diabetes mellitus glucomannan nutritional intervention meta-analysis RCTs |
url | https://www.mdpi.com/2072-6643/15/3/601 |
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