Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis
Progressive immune dysfunction associated with aging is known as immunosenescence. The age-related deterioration of immune function is accompanied by chronic inflammation and microenvironment changes. Immunosenescence can affect both innate and acquired immunity. Sepsis is a systemic inflammatory re...
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| Format: | Article |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.917293/full |
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| author | Xuan Lu Xuan Lu Yun-Mei Yang Yun-Mei Yang Yuan-Qiang Lu Yuan-Qiang Lu |
| author_facet | Xuan Lu Xuan Lu Yun-Mei Yang Yun-Mei Yang Yuan-Qiang Lu Yuan-Qiang Lu |
| author_sort | Xuan Lu |
| collection | DOAJ |
| description | Progressive immune dysfunction associated with aging is known as immunosenescence. The age-related deterioration of immune function is accompanied by chronic inflammation and microenvironment changes. Immunosenescence can affect both innate and acquired immunity. Sepsis is a systemic inflammatory response that affects parenchymal organs, such as the respiratory system, cardiovascular system, liver, urinary system, and central nervous system, according to the sequential organ failure assessment (SOFA). The initial immune response is characterized by an excess release of inflammatory factors, followed by persistent immune paralysis. Moreover, immunosenescence was found to complement the severity of the immune disorder following sepsis. Furthermore, the immune characteristics associated with sepsis include lymphocytopenia, thymus degeneration, and immunosuppressive cell proliferation, which are very similar to the characteristics of immunosenescence. Therefore, an in-depth understanding of immunosenescence after sepsis and its subsequent effects on the organs may contribute to the development of promising therapeutic strategies. This paper focuses on the characteristics of immunosenescence after sepsis and rigorously analyzes the possible underlying mechanism of action. Based on several recent studies, we summarized the relationship between immunosenescence and sepsis-related organs. We believe that the association between immunosenescence and parenchymal organs might be able to explain the delayed consequences associated with sepsis. |
| first_indexed | 2024-04-14T04:28:31Z |
| format | Article |
| id | doaj.art-77280bd7faf642218d57ce38c73c160a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-14T04:28:31Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-77280bd7faf642218d57ce38c73c160a2022-12-22T02:12:11ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-07-011310.3389/fimmu.2022.917293917293Immunosenescence: A Critical Factor Associated With Organ Injury After SepsisXuan Lu0Xuan Lu1Yun-Mei Yang2Yun-Mei Yang3Yuan-Qiang Lu4Yuan-Qiang Lu5Department of Geriatric and Emergency Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaThe Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province, Hangzhou, ChinaDepartment of Geriatric and Emergency Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaThe Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province, Hangzhou, ChinaDepartment of Geriatric and Emergency Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaThe Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province, Hangzhou, ChinaProgressive immune dysfunction associated with aging is known as immunosenescence. The age-related deterioration of immune function is accompanied by chronic inflammation and microenvironment changes. Immunosenescence can affect both innate and acquired immunity. Sepsis is a systemic inflammatory response that affects parenchymal organs, such as the respiratory system, cardiovascular system, liver, urinary system, and central nervous system, according to the sequential organ failure assessment (SOFA). The initial immune response is characterized by an excess release of inflammatory factors, followed by persistent immune paralysis. Moreover, immunosenescence was found to complement the severity of the immune disorder following sepsis. Furthermore, the immune characteristics associated with sepsis include lymphocytopenia, thymus degeneration, and immunosuppressive cell proliferation, which are very similar to the characteristics of immunosenescence. Therefore, an in-depth understanding of immunosenescence after sepsis and its subsequent effects on the organs may contribute to the development of promising therapeutic strategies. This paper focuses on the characteristics of immunosenescence after sepsis and rigorously analyzes the possible underlying mechanism of action. Based on several recent studies, we summarized the relationship between immunosenescence and sepsis-related organs. We believe that the association between immunosenescence and parenchymal organs might be able to explain the delayed consequences associated with sepsis.https://www.frontiersin.org/articles/10.3389/fimmu.2022.917293/fullsepsisimmune agingimmunosenescenceimmunosuppressionmyeloid-derived suppressor cells |
| spellingShingle | Xuan Lu Xuan Lu Yun-Mei Yang Yun-Mei Yang Yuan-Qiang Lu Yuan-Qiang Lu Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis Frontiers in Immunology sepsis immune aging immunosenescence immunosuppression myeloid-derived suppressor cells |
| title | Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis |
| title_full | Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis |
| title_fullStr | Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis |
| title_full_unstemmed | Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis |
| title_short | Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis |
| title_sort | immunosenescence a critical factor associated with organ injury after sepsis |
| topic | sepsis immune aging immunosenescence immunosuppression myeloid-derived suppressor cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.917293/full |
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