Primary and secondary immune checkpoint inhibitors resistance in colorectal cancer: Key mechanisms and ways to overcome resistance
Immune checkpoint inhibitors (ICIs) have significantly advanced colorectal cancer treatment in recent years. Antibodies that target the proteins programmed cell death-1 (PD-1), programmed cell death-1 ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) are among the ICIs that...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Cancer Treatment and Research Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468294222001344 |
| _version_ | 1811295662339260416 |
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| author | Hassan Abushukair Obada Ababneh Sara Zaitoun Anwaar Saeed |
| author_facet | Hassan Abushukair Obada Ababneh Sara Zaitoun Anwaar Saeed |
| author_sort | Hassan Abushukair |
| collection | DOAJ |
| description | Immune checkpoint inhibitors (ICIs) have significantly advanced colorectal cancer treatment in recent years. Antibodies that target the proteins programmed cell death-1 (PD-1), programmed cell death-1 ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) are among the ICIs that are currently being used in clinical practice. However, in colorectal cancer, ICI's effectiveness is limited to a fraction of patients with microsatellite instability-high (MSI-H), which only accounts for about 5% of advanced cases. The tumor microenvironment and intrinsic changes in tumor cells are just a couple of the many mechanisms that play a role in ICI primary or secondary resistance. In order to advance precision medicine and broaden the population benefiting from ICI, this paper highlights the main underlying mechanisms of ICIs resistance and suggested techniques to overcome it. |
| first_indexed | 2024-04-13T05:36:41Z |
| format | Article |
| id | doaj.art-77289718d9c0471ab99794dbd4b27196 |
| institution | Directory Open Access Journal |
| issn | 2468-2942 |
| language | English |
| last_indexed | 2024-04-13T05:36:41Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Treatment and Research Communications |
| spelling | doaj.art-77289718d9c0471ab99794dbd4b271962022-12-22T03:00:15ZengElsevierCancer Treatment and Research Communications2468-29422022-01-0133100643Primary and secondary immune checkpoint inhibitors resistance in colorectal cancer: Key mechanisms and ways to overcome resistanceHassan Abushukair0Obada Ababneh1Sara Zaitoun2Anwaar Saeed3Faculty of Medicine, Jordan University of Science and Technology, 22110, Irbid, JordanFaculty of Medicine, Jordan University of Science and Technology, 22110, Irbid, JordanFaculty of Medicine, Yarmouk University, 21163, Irbid, JordanDepartment of Medicine, Division of Medical Oncology, University of Kansas Cancer Center, 66205, Kansas City, KS, United States of America; Corresponding author at: Department of Medicine, Division of Medical Oncology, University of Kansas Cancer Center, 2330 Shawnee Mission Pkwy, 66205, Kansas City, KS, United States of America.Immune checkpoint inhibitors (ICIs) have significantly advanced colorectal cancer treatment in recent years. Antibodies that target the proteins programmed cell death-1 (PD-1), programmed cell death-1 ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) are among the ICIs that are currently being used in clinical practice. However, in colorectal cancer, ICI's effectiveness is limited to a fraction of patients with microsatellite instability-high (MSI-H), which only accounts for about 5% of advanced cases. The tumor microenvironment and intrinsic changes in tumor cells are just a couple of the many mechanisms that play a role in ICI primary or secondary resistance. In order to advance precision medicine and broaden the population benefiting from ICI, this paper highlights the main underlying mechanisms of ICIs resistance and suggested techniques to overcome it.http://www.sciencedirect.com/science/article/pii/S2468294222001344Colorectal cancerImmune checkpoint inhibitorsResistanceMechanismCombination therapy |
| spellingShingle | Hassan Abushukair Obada Ababneh Sara Zaitoun Anwaar Saeed Primary and secondary immune checkpoint inhibitors resistance in colorectal cancer: Key mechanisms and ways to overcome resistance Cancer Treatment and Research Communications Colorectal cancer Immune checkpoint inhibitors Resistance Mechanism Combination therapy |
| title | Primary and secondary immune checkpoint inhibitors resistance in colorectal cancer: Key mechanisms and ways to overcome resistance |
| title_full | Primary and secondary immune checkpoint inhibitors resistance in colorectal cancer: Key mechanisms and ways to overcome resistance |
| title_fullStr | Primary and secondary immune checkpoint inhibitors resistance in colorectal cancer: Key mechanisms and ways to overcome resistance |
| title_full_unstemmed | Primary and secondary immune checkpoint inhibitors resistance in colorectal cancer: Key mechanisms and ways to overcome resistance |
| title_short | Primary and secondary immune checkpoint inhibitors resistance in colorectal cancer: Key mechanisms and ways to overcome resistance |
| title_sort | primary and secondary immune checkpoint inhibitors resistance in colorectal cancer key mechanisms and ways to overcome resistance |
| topic | Colorectal cancer Immune checkpoint inhibitors Resistance Mechanism Combination therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2468294222001344 |
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