Glucocorticoid Regulates the Synthesis of Porcine Muscle Protein through m<sup>6</sup>A Modified Amino Acid Transporter <i>SLC7A7</i>
The occurrence of stress is unavoidable in the process of livestock production, and prolonged stress will cause the decrease of livestock productivity. The stress response is mainly regulated by the hypothalamic-pituitary-adrenal axis (HPA axis), which produces a large amount of stress hormones, nam...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/2/661 |
| Summary: | The occurrence of stress is unavoidable in the process of livestock production, and prolonged stress will cause the decrease of livestock productivity. The stress response is mainly regulated by the hypothalamic-pituitary-adrenal axis (HPA axis), which produces a large amount of stress hormones, namely glucocorticoids (GCs), and generates a severe impact on the energy metabolism of the animal body. It is reported that m<sup>6</sup>A modification plays an important role in the regulation of stress response and also participates in the process of muscle growth and development. In this study, we explored the effect of GCs on the protein synthesis procession of porcine skeletal muscle cells (PSCs). We prove that dexamethasone affects the expression of <i>SLC7A7</i>, a main amino acid transporter for protein synthesis by affecting the level of m<sup>6</sup>A modification in PSCs. In addition, we find that <i>SLC7A7</i> affects the level of PSC protein synthesis by regulating the conduction of the mTOR signaling pathway, which indicates that the reduction of <i>SLC7A7</i> expression may alleviate the level of protein synthesis under stress conditions. |
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| ISSN: | 1661-6596 1422-0067 |